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Imaging in Neuroscience: A Laboratory Manual

Edited By Fritjof Helmchen, Brain Research Institute, University of Zurich, Switzerland; Arthur Konnerth, Institute for Neurosciences, Technical University Munich, Germany; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 1084 pp., illus., index
Paperback • $200.00 $140.00 • ISBN 978-0-879699-38-3

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Imaging in Neuroscience: A Laboratory Manual

Edited By Fritjof Helmchen, Brain Research Institute, University of Zurich, Switzerland; Arthur Konnerth, Institute for Neurosciences, Technical University Munich, Germany; Series Editor, Rafael Yuste, Howard Hughes Medical Institute, Columbia University

© 2011 • 1084 pp., illus., index
Hardcover • $287.00 $200.90 • ISBN 978-0-879699-37-6

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Neuronal Guidance: The Biology of Brain Wiring

Edited By Marc Tessier-Lavigne, The Rockefeller University; Alex L. Kolodkin, Johns Hopkins University School of Medicine

© 2011 • 397 pp., illus. (87 color, 6 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-0-879698-97-3

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An Introduction to Animal Behavior: An Integrative Approach

By Michael J. Ryan, The University of Texas at Austin; Walter Wilczynski, Neuroscience Institute, Georgia State University, Atlanta

© 2011 • 258 pp., illus. (88 color, 3 b/w), index
Paperback • $46.00 • ISBN 978-0-879698-58-4

The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.

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An Introduction to Animal Behavior: An Integrative Approach

By Michael J. Ryan, The University of Texas at Austin; Walter Wilczynski, Neuroscience Institute, Georgia State University, Atlanta

© 2011 • 258 pp., illus. (88 color, 3 b/w), index
Hardcover • $81.00 • ISBN 978-1-936113-18-7

The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.

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Incurable: A Life after Diagnosis

By Charles Harris

© 2011 • 280 pp., illus.
Hardcover • $31.00 • ISBN 978-1-936113-10-1

In March 2009, during a routine medical exam, Charles Harris learned that he had incurable cancer. Although a private man, he began a blog to keep family and friends current on his progress, and found a wider audience. From the blog was born Incurable, an account of a man’s struggle to live vibrantly and with courage in the face of a fatal illness. An entrepreneur and investor by profession, Charles Harris writes about living and dying, friendship and fellowship, sports and wine, race horses and recessions. His style is optimistic, direct, humorous, and companionable. Readers will find his voice brave, inspirational, and an eloquent reminder that an understanding of cancer remains an urgent goal in biomedicine. Proceeds from this book will be used by the Harris family in support of cancer research.

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Guide to the Human Genome

By Stewart Scherer

© 2011 • 1,008 pp., illus. (212 b/w), appendix, index
Paperback • $79 • ISBN 978-0-879699-44-4

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure—from the molecular and cellular levels to developmental and physiological processes. In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest.

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Auxin Signaling: From Synthesis to Systems Biology

Edited By Mark Estelle, University of California, San Diego; Dolf Weijers, Wageningen University, The Netherlands; Karin Ljung, Umeå Plant Science Centre, Umeå, Sweden; Ottoline Leyser, University of York, United Kingdom

© 2011 • 253 pp., illus. (36 color, 13 b/w), index
Trim size: 7” x 10”
Hardcover • $135 $33.75 • ISBN 978-0-879698-98-0

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Yeast Intermediary Metabolism

By Dan G. Fraenkel, Harvard Medical School

© 2011 • 434 pp., illus. (138 b/w), appendix, index
Hardcover • $128 • ISBN 978-0-879697-97-6

The intermediary metabolism of small molecules is the meat and potatoes of cell function. The pathways and modes of obtaining energy, degradation and utilization of exogenous organic nutrients, and formation of the building blocks of the main macromolecules were a major focus of research in biology from the turn of the 20th century into the 1970s. Other matters have come to prominence, but the field is active, with interesting problems that are central to biology and medicine. Molecular biology developed through the use of one bacterium, Eschericha coli, with the saying “What’s true for E. coli is true for elephants.” In recent years, an analogous workhorse has been the eukaryotic microbe baker’s yeast, Saccharomyces cerevisiae, used in many studies of cell biology common to multicellular organisms. This book explains metabolism as based on Saccharomyces. The topics include central metabolic pathways; catabolism; fermentation; respiration; biosynthesis of small molecules including cofactors; the metabolism of lipids, polysaccharides, and storage molecules; inorganic ions; transport and compartments; the global analysis of metabolism; and issues of metabolic toxicity. It can be used in courses and as a reference book for research investigators.

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Paperback • $46.00 • ISBN 978-0-879698-88-1