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A Short Guide to the Human Genome

By Stewart Scherer

© 2008 • 173 pp., illus., index
Paperback • $29 $20.30 • ISBN 978-087969791-4

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Single-Molecule Techniques: A Laboratory Manual

Edited By Paul R. Selvin, University of Illinois, Urbana-Champaign; Taekjip Ha, University of Illinois, Urbana-Champaign

© 2008 • 507 pp., illus., appendix, index
Paperback • $169.00 • ISBN 978-087969775-4

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The Skeletal System
(Cold Spring Harbor Monograph Series 53)

Edited By Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

© 2009 • 365 pp., illus., index
Hardcover • $95 $47.50 • ISBN 978-087969825-6

The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.

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Speaking of Genetics: A Collection of Interviews

Edited By Jane Gitschier, Institute for Human Genetics, University of California, San Francisco

© 2011 • 259 pp., illus., further reading, index
Paperback • $19.00 • ISBN 978-1-936113-03-3

These 22 interviews were conducted by University of California Professor Jane Gitschier for publication in the scientific journal PLoS Genetics over the past 5 years. Here these interviews are presented as a single, stand-alone collection for the first time.

The collection makes a compelling read by capturing exhilarating moments of discovery on a wide range of genetic questions as recounted by the scientists themselves. We also hear from scientists whose careers have taken on a broader role—a University president, a master teacher, an author, the founder of a company, and an explorer. Further perspective is provided by several non-scientists whose work helps frame our understanding and practice of genetics; these include a judge, a reporter, an administrator, and an historian of science. Together, the interviews in this collection bring to life the practice and societal implications of contemporary genetics.

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Statistics at the Bench: A Step-by-Step Handbook for Biologists

By Martina Bremer, Department of Mathematics, San Jose State University, California; Rebecca W. Doerge, Departments of Statistics and Agronomy, Purdue University, Indiana

© 2010 • 167 pp., illus., indexes
Concealed wire binding • $61.00 $42.70 • ISBN 978-0-879698-57-7

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The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives, Updated and Expanded Edition

By Philip R. Reilly

© 2008 • 300 pp., illus., bibliography, index
Paperback • $16 • ISBN 978-087969943-7

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Sydney Brenner: A Biography

By Errol C. Friedberg, University of Texas Southwestern Medical Center at Dallas

© 2011 • 334 pp., illus. (59 b/w), index
Trim size: 6” x 9”
Hardcover • $40.00 • ISBN 978-0-879699-47-5

Over his long and inspiring career, the Nobel Laureate Sydney Brenner has made some of the most significant and game-changing discoveries in the field of molecular biology. But Brenner’s reach has extended well beyond his own research to inspire new generations of young scientists and to promote the development of science and biotechnology around the world. Based on his personal recollections, with contributions and correspondence from his close friends and colleagues, this book tells the lively story, not only of Brenner himself, but of what came to be known as the “golden age” of biology.About the author: Errol C. Friedberg, M.D., is the Senator Betty and Dr. Andy Andujar Distinguished Professor and Chair at the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. A Fellow of the Royal College of Pathologists and recipient of the Rous Whipple Award from the American Society for Investigative Pathology, Friedberg also serves as Editor-in-Chief of the journal DNA Repair. Friedberg is the author of Cancer Answers, Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms, The Writing Life of James D. Watson, and From Rags to Riches: The Phenomenal Rise of The University of Texas Southwestern Medical Center at Dallas. He is also senior author of the textbook DNA Repair & Mutagenesis, and has edited and annotated a series of interviews published as Sydney Brenner: My Life in Science.

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Symmetry Breaking in Biology

Edited By Rong Li, The Stowers Institute for Medical Research; Bruce Bowerman, Institute of Molecular Biology and Department of Biology, University of Oregon

© 2010 • 301 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-89-8

Symmetry breaking events are critical for the survival of living systems. They are required for cell division, development, and movement in all organisms from single-celled species to human beings. Moreover, in multicellular organisms, symmetry breaking allows the generation of cells with different fates and underpins the complex arrangement of tissues and organs achieved during embryogenesis.

Written and edited by experts in the field, this volume explores how symmetry breaking occurs in biology and the roles of these events at numerous different levels. The contributors examine the mechanisms by which cells polarize, divide asymmetrically, and produce asymmetric structures, providing examples from bacteria, yeast, plants, invertebrates, and mammals.

Including discussions of the molecular basis of polarization mechanisms, asymmetric division of stem cells during development, the generation of left-right asymmetry of the body axis in mammals, and theoretical approaches to symmetry breaking, the volume is a vital reference for molecular, cell, and developmental biologists, as well as physical scientists interested in how and why symmetry breaking occurs in living systems.

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The Synapse

Edited By Morgan Sheng, Genentech, Department of Neuroscience; Bernardo Sabatini, Harvard Medical School; Thomas C. Südhof, Stanford University School of Medicine

© 2012 • 397 pp., illus. (78 4C and 6 B&W images), index
Hardcover • $135 • ISBN 978-1-936113-02-6

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Paperback • $49 $9.80 • ISBN 978-087969810-2

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.