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RNAi: A Guide to Gene Silencing

Edited By Gregory J. Hannon, Cold Spring Harbor Laboratory

© 2003 • 436 pp., illus., index
Printed hardcover • $130 $26.00 • ISBN 978-087969641-2

The ability of double stranded RNA to inhibit the expression of genes with an appropriate sequence can be harnessed to silence target genes in vitro in a new and powerful way. This volume combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.

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Manipulating the Mouse Embryo: A Laboratory Manual (Third Edition)

By Andras Nagy, Samuel Lunenfeld Research Institute; Marina Gertsenstein, Samuel Lunenfeld Research Institute; Kristina Vintersten, European Molecular Biology Laboratory; Richard Behringer, University of Texas M.D. Anderson Cancer Center

© 2003 • 764 pp., illus., appendices, index
Paperback • $169.00 • ISBN 978-087969591-0

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Early Development of Xenopus laevis: A Laboratory Manual

By Hazel L. Sive, Whitehead Institute for Biomedical Research; Robert M. Grainger, University of Virginia, Charlottesville; Richard M. Harland, University of California, Berkeley

© 2000 • 338 pp., illus., color plate, appendices, index
Paperback • $40.00 • ISBN 978-087969942-0

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The Coiled Spring: How Life Begins

By Ethan Bier, University of California, San Diego
With an Introduction by Cliff Tabin, Harvard Medical School

© 2000 • 252 pp., illus., color plates, index, glossary, bibliography
Cloth • $62 $15.50 • ISBN 978-087969562-0

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Drosophila Protocols

By William Sullivan, University of California, Santa Cruz; Michael Ashburner, University of Cambridge; R. Scott Hawley, University of California, Davis

© 2000 • 728 pp., illus., appendices, index
Paperback • $81.00 • ISBN 978-087969827-0

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Pattern Formation during Development
(Cold Spring Harbor Symposia on Quantitative Biology LXII)

© 1997 • 570 pp., illus., color plates, appendices, indexes
Cloth • $131 $26.20 • ISBN 978-087969535-4

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C. elegans II
(Cold Spring Harbor Monograph Series 33)

Edited By Donald L. Riddle, University of Missouri, Columbia; Thomas Blumenthal, Indiana University; Barbara J. Meyer, University of California, Berkeley; James R. Priess, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle

© 1997 • 1222 pp., illus., color plates, index
Paper • $75 • ISBN 978-087969532-3

Studies of the cells and genes of the nematode C. elegans havebecome a cornerstone of current biology. A classic 1988 Cold SpringHarbor monograph,The Nematode Caenorhabditis elegans,described the basic genetics, anatomy and developmentof the organism. Now, in that authoritative tradition, comes C. elegansII -- not a second edition but a book that breaks new ground and definesthe current status of the field, providing a detailed molecularexplanation of how development is regulated and the nervous systemspecifies varied aspects of behavior. This volume is a must for anyinvestigator doing worm studies but it has been written and rigorouslyedited to illuminate for a wider community of investigators in celland molecular biology who should know how new knowledge of C. elegansrelates to their own specialty.

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The Development of Drosophila melanogaster

Edited By Michael Bate, University of Cambridge; Alfonso Martinez Arias, University of Cambridge

© 1993 • 1,564 pp. (2-volume set), illus., indexes
Paperback • $256.00 • ISBN 978-087969899-7

The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.

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Targeted Mutagenesis in Mice: A Video Guide

By Roger A. Pedersen, University of California, San Francisco; Virginia Papaioannou, Columbia University

© 1993 • 70-minute video
PAL • $210 • ISBN 978-087969430-0

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Transgenic Techniques in Mice: A Video Guide

Instructors: Roger Pedersen, University of California, San Francisco; Janet Rossant

© 1989 • 68-minute video
PAL • $179 • ISBN 978-087969952-9