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Cell-Cell Junctions

Edited By W. James Nelson, Stanford University; Elaine Fuchs, The Rockefeller University

© 2010 • 443 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-84-3

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Generation and Interpretation of Morphogen Gradients

Edited By James Briscoe, MRC National Institute for Medical Research; Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology; Jean-Paul Vincent, MRC National Institute for Medical Research

© 2010 • 308 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-81-2

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

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The Skeletal System
(Cold Spring Harbor Monograph Series 53)

Edited By Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

© 2009 • 365 pp., illus., index
Hardcover • $95 $47.50 • ISBN 978-087969825-6

The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.

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Emerging Model Organisms: A Laboratory Manual, Volume 1

© 2009 • 592 pp., illus., appendix, index
Paperback • $89 $44.50 • ISBN 978-087969872-0

Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo

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Emerging Model Organisms: A Laboratory Manual, Volume 1

© 2009 • 592 pp., illus., appendix, index
Hardcover • $158 $79.00 • ISBN 978-087969826-3

Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Paperback edition does not include online access)
Paperback • $126 $63.00 • ISBN 978-087969862-1

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $155.00 • ISBN 978-087969861-4

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Biology of Drosophila

Edited By M. Demerec

© 2008 • 632 pp., illus., indexes
Paperback • $42.00 • ISBN 978-087969828-7

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C. elegans Atlas

By David H. Hall, Albert Einstein College of Medicine, New York; Zeynep F. Altun, Albert Einstein College of Medicine, New York

© 2008 • 348 pp., illus., appendix, index
Concealed wire binding • $128.00 $89.60 • ISBN 978-087969715-0

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C. elegans Atlas

By David H. Hall, Albert Einstein College of Medicine, New York; Zeynep F. Altun, Albert Einstein College of Medicine, New York

© 2008 • 348 pp., illus., appendix, index
Hardcover • $179.00 • ISBN 978-087969794-5