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Immunoreceptor Signaling

Subject Area(s):  Cell BiologyImmunology, Vaccines, and Therapeutic Proteins

Edited by Lawrence E. Samelson, National Institutes of Health; Andrey Shaw, Washington University School of Medicine

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© 2011 • 282 pp., illus. (49 color, 7 b/w), index
Trim size: 7 x 10
Hardcover • $135 67.50 • ISBN  978-0-879698-96-6
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The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structures of the T-cell and B-cell immunoreceptors, the numerous kinases and adaptors that associate with their intracellular tails, and the downstream signaling pathways that lead to transcription of interleukins and other outputs. Other contributions examine the roles of other receptors, co-stimulatory signals, and innate immune responses in regulation of immunoreceptor signaling.

The spatial organization of the immunological synapses connecting lymphocytes and antigen-presenting cells is also discussed, along with the role of the cytoskeleton in immunoreceptor function. Computational models of the signaling processes complete the volume, making it essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.

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Structural Biology of the T-Cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling
Kai W. Wucherpfennig, Etienne Gagnon, Melissa J. Call, Eric S. Huseby, and Matthew E. Call
ITAM-mediated Signaling by the T-Cell Antigen Receptor
Paul E. Love and Sandra M. Hayes
It’s All about Change: The Antigen-driven Initiation of B-Cell Receptor Signaling
Wanli Liu, Hae Won Sohn, Pavel Tolar, and Susan K. Pierce
The Cytoskeleton Coordinates the Early Events of B-Cell Activation
Naomi E. Harwood and Facundo D. Batista
Src-Family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk
Clifford A. Lowell
ZAP-70: An Essential Kinase in T-Cell Signaling
Haopeng Wang, Theresa A. Kadlecek, Byron B. Au-Yeung, Hanna E. Sjölin Goodfellow, Lih-Yun Hsu, Tanya S. Freedman, and Arthur Weiss
The LAT Story: ATale of Cooperativity, Coordination, and Choreography
Lakshmi Balagopalan, Nathan P. Coussens, Eilon Sherman, Lawrence E. Samelson, and Connie L. Sommers
Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76
Martha S. Jordan and Gary A. Koretzky
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Amy H. Andreotti, Pamela L. Schwartzberg, Raji E. Joseph, and Leslie J. Berg
An Enigmatic Tail of CD28 Signaling
Jonathan S. Boomer and Jonathan M. Green
SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors
André Veillette
The Coordination of T-Cell Function by Serine/Threonine Kinases
David Finlay and Doreen Cantrell
Lipid Signaling in T-Cell Development and Function
Yina H. Huang and Karsten Sauer
Antigen Receptor Signaling to NF-kB via CARMA1, BCL10, and MALT1
Margot Thome, Jean Enno Charton, Christiane Pelzer, and Stephan Hailfinger
Mediation of T-Cell Activation by Actin Meshworks
Peter Beemiller and Matthew F. Krummel
Understanding the Structure and Function of the Immunological Synapse
Michael L. Dustin, Arup K. Chakraborty, and Andrey S. Shaw
Perspectives for Computer Modeling in the Study of T-Cell Activation
Jesse Coward, Ronald N. Germain, and Grégoire Altan-Bonnet
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