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NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer

Edited By Michael Karin, University of California, San Diego; Louis M. Staudt, National Cancer Institute

© 2010 • 272 pp., illus. (42 color, 10 b/w), index
Trim size: 7” x 10”
Paperback • $49 • ISBN 978-1-936113-55-2

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Paperback edition does not include online access)
Paperback • $126 $63.00 • ISBN 978-087969862-1

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $155.00 • ISBN 978-087969861-4

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Concerning the Origin of Malignant Tumours

By Theodor Boveri; Translated and annotated by Sir Henry Harris

© 2008 • 82 pp.
Paperback • $25.00 • ISBN 978-087969788-4

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The TGF-β Family
(Cold Spring Harbor Monograph Series 50)

Edited By Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

© 2008 • 1,114 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969752-5

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

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Molecular Biology of Aging
(Cold Spring Harbor Monograph Series 51)

Edited By Leonard P. Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas C. Wallace, University of California, Irvine

© 2008 • 610 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969824-9

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.

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Regulatory RNAs
(Cold Spring Harbor Symposia on Quantitative Biology LXXI)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory, New York; David Stewart, Cold Spring Harbor Laboratory, New York

© 2006 • 574 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $155.00 • ISBN 978-087969817-1

“Regulatory RNAs” was the theme of the 71st annual Cold Spring Harbor Symposium on Quantitative Biology, where scientists from around the world presented the latest advances in the biology of RNAs, including RNA interference, transcriptional and translational control, RNA editing, and the role of RNAs in biological circuits and epigenetic events. Investigators discussed the latest technologies aimed at large-scale characterization of RNAs, as well as the roles of small RNAs in development and cancer. This volume is a timely survey of this important new area of molecular biology.

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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Paperback • $49 $9.80 • ISBN 978-087969810-2

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

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Telomeres, Second Edition
(Cold Spring Harbor Monograph Series 45)

Edited By Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Hardcover • $139 $27.80 • ISBN 978-087969734-1

An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.