More INFO on
this Product

Generation and Interpretation of Morphogen Gradients

Edited By James Briscoe, MRC National Institute for Medical Research; Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology; Jean-Paul Vincent, MRC National Institute for Medical Research

© 2010 • 308 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-81-2

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

More INFO on
this Product

Genes & Signals

By Mark Ptashne, Memorial Sloan-Kettering Cancer Center; Alexander Gann, Cold Spring Harbor Laboratory

© 2002 • 192 pp., illus., index
Kindle • ISBN 978-087969633-7

More INFO on
this Product

Genes, Girls, and Gamow: After the Double Helix

By James D. Watson, Cold Spring Harbor Laboratory

© 2001 • 336 pp., 43 illus., 22 letters
NOTE: For distribution in the United States and Canada only.
Hardcover • $53 $26.50 • ISBN 978-037541283-7

More INFO on
this Product

A Genetic Switch, Third Edition, Phage Lambda Revisited

By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York

© 2004 • 154 pp., illus., appendices, index
Paperback • $40.00 • ISBN 978-087969716-7

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

More INFO on
this Product

Genetic Variation: A Laboratory Manual

Edited By Michael P. Weiner, RainDance Technologies, Inc., Guilford, Connecticut; Stacey B. Gabriel, The Broad Institute, Massachusetts Institute of Technology, Cambridge; J. Claiborne Stephens, Motif BioSciences, New York

© 2007 • 472 pp., illus., appendix, index
Paperback • $165 • ISBN 978-087969780-8

More INFO on
this Product

Genetics of Complex Human Diseases: A Laboratory Manual

Edited By Ammar Al-Chalabi, MRC Centre for Neurodegeneration Research, King’s College London; Laura Almasy, Southwest Foundation for Biomedical Research, San Antonio, Texas

© 2009 • 220 pp., illus., index
Hardcover • $162.00 • ISBN 978-087969882-9

Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

More INFO on
this Product

Genetics of Complex Human Diseases: A Laboratory Manual

Edited By Ammar Al-Chalabi, MRC Centre for Neurodegeneration Research, King’s College London; Laura Almasy, Southwest Foundation for Biomedical Research, San Antonio, Texas

© 2009 • 220 pp., illus., index
Paperback • $97.00 • ISBN 978-087969883-6

Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

More INFO on
this Product

Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

© 2013 • 704 pp., illus (3 4C, 606 B&W), index
Hardcover • $55 • ISBN 978-0-879698-59-1

More INFO on
this Product

Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Paperback • $59 $14.75 • ISBN 978-087969807-2

More INFO on
this Product

Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969806-5