© 2011 • 282 pp., illus. (49 color, 7 b/w), index
Trim size: 7” x 10”
Hardcover • $135 33.75 • ISBN  978-0-879698-96-6
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The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions.

Written and edited by experts in the field, this collection from Cold Srping Harbor Perspectives in Biology includes contributions covering the structures of the T-cell and B-cell immunoreceptors, the numerous kinases and adaptors that associate with their intracellular tails, and the downstream signaling pathways that lead to transcription of interleukins and other outputs. Other contributions examine the roles of other receptors, co-stimulatory signals, and innate immune responses in regulation of immunoreceptor signaling.

The spatial organization of the immunological synapses connecting lymphocytes and antigen-presenting cells is also discussed, along with the role of the cytoskeleton in immunoreceptor function. Computational models of the signaling processes complete the volume, making it essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.

Preface

Structural Biology of the T-Cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling

Kai W. Wucherpfennig, Etienne Gagnon, Melissa J. Call, Eric S. Huseby, and Matthew E. Call

ITAM-mediated Signaling by the T-Cell Antigen Receptor

Paul E. Love and Sandra M. Hayes

It’s All about Change: The Antigen-driven Initiation of B-Cell Receptor Signaling

Wanli Liu, Hae Won Sohn, Pavel Tolar, and Susan K. Pierce

The Cytoskeleton Coordinates the Early Events of B-Cell Activation

Naomi E. Harwood and Facundo D. Batista

Src-Family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk

Clifford A. Lowell

ZAP-70: An Essential Kinase in T-Cell Signaling

Haopeng Wang, Theresa A. Kadlecek, Byron B. Au-Yeung, Hanna E. Sjölin Goodfellow, Lih-Yun Hsu, Tanya S. Freedman, and Arthur Weiss

The LAT Story: ATale of Cooperativity, Coordination, and Choreography

Lakshmi Balagopalan, Nathan P. Coussens, Eilon Sherman, Lawrence E. Samelson, and Connie L. Sommers

Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76

Martha S. Jordan and Gary A. Koretzky

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

Amy H. Andreotti, Pamela L. Schwartzberg, Raji E. Joseph, and Leslie J. Berg

An Enigmatic Tail of CD28 Signaling

Jonathan S. Boomer and Jonathan M. Green

SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors

André Veillette

The Coordination of T-Cell Function by Serine/Threonine Kinases

David Finlay and Doreen Cantrell

Lipid Signaling in T-Cell Development and Function

Yina H. Huang and Karsten Sauer

Antigen Receptor Signaling to NF-kB via CARMA1, BCL10, and MALT1

Margot Thome, Jean Enno Charton, Christiane Pelzer, and Stephan Hailfinger

Mediation of T-Cell Activation by Actin Meshworks

Peter Beemiller and Matthew F. Krummel

Understanding the Structure and Function of the Immunological Synapse

Michael L. Dustin, Arup K. Chakraborty, and Andrey S. Shaw

Perspectives for Computer Modeling in the Study of T-Cell Activation

Jesse Coward, Ronald N. Germain, and Grégoire Altan-Bonnet

Index