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NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer

Edited By Michael Karin, University of California, San Diego; Louis M. Staudt, National Cancer Institute

© 2010 • 272 pp., illus. (42 color, 10 b/w), index
Trim size: 7” x 10”
Paperback • $49 • ISBN 978-1-936113-55-2

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Emerging Model Organisms: A Laboratory Manual, Volume 2

© 2010 • 624 pp., illus. (102 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Paperback • $91.00 • ISBN 978-0-879698-65-2

This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

Review of Volume 1:
“The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now, he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome, describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology

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Emerging Model Organisms: A Laboratory Manual, Volume 2

© 2010 • 624 pp., illus. (102 b/w), appendices, index
Trim size: 8-1/2” x 10-7/8”
Hardcover • $162.00 • ISBN 978-0-879699-45-1

This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

Review of Volume 1:
“The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now, he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome, describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology

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Symmetry Breaking in Biology

Edited By Rong Li, The Stowers Institute for Medical Research; Bruce Bowerman, Institute of Molecular Biology and Department of Biology, University of Oregon

© 2010 • 301 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-89-8

Symmetry breaking events are critical for the survival of living systems. They are required for cell division, development, and movement in all organisms from single-celled species to human beings. Moreover, in multicellular organisms, symmetry breaking allows the generation of cells with different fates and underpins the complex arrangement of tissues and organs achieved during embryogenesis.

Written and edited by experts in the field, this volume explores how symmetry breaking occurs in biology and the roles of these events at numerous different levels. The contributors examine the mechanisms by which cells polarize, divide asymmetrically, and produce asymmetric structures, providing examples from bacteria, yeast, plants, invertebrates, and mammals.

Including discussions of the molecular basis of polarization mechanisms, asymmetric division of stem cells during development, the generation of left-right asymmetry of the body axis in mammals, and theoretical approaches to symmetry breaking, the volume is a vital reference for molecular, cell, and developmental biologists, as well as physical scientists interested in how and why symmetry breaking occurs in living systems.

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Cell-Cell Junctions

Edited By W. James Nelson, Stanford University; Elaine Fuchs, The Rockefeller University

© 2010 • 443 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-84-3

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Generation and Interpretation of Morphogen Gradients

Edited By James Briscoe, MRC National Institute for Medical Research; Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology; Jean-Paul Vincent, MRC National Institute for Medical Research

© 2010 • 308 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-81-2

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

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Live Cell Imaging: A Laboratory Manual, Second Edition

Edited By Robert D. Goldman, Feinberg School of Medicine Northwestern University; Jason R. Swedlow, The University of Dundee; David L. Spector, Cold Spring Harbor Laboratory

© 2010 • 736 pp., illus., appendix, index
Paperback • $169.00 $118.30 • ISBN 978-0-879698-93-5

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. They include advances in atomic force microscopy, structured illumination microscopy and other 3-D approaches, as well as imaging in single cells in animals and in plants. New analytical options include live high-throughput/high-content screening in mammalian cells and computational analysis of live cell data. The manual presents hands-on techniques as well as background material, and can serve as a text in advanced courses. The first section covers principles and fundamental issues of detection and imaging; the second provides detailed protocols for imaging live systems.

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Live Cell Imaging: A Laboratory Manual, Second Edition

Edited By Robert D. Goldman, Feinberg School of Medicine Northwestern University; Jason R. Swedlow, The University of Dundee; David L. Spector, Cold Spring Harbor Laboratory

© 2010 • 736 pp., illus., appendix, index
Hardcover • $246.00 $172.20 • ISBN 978-0-879698-92-8

The second edition of Live Cell Imaging: A Laboratory Manual expands upon and extends the collection of established and evolving methods for studying dynamic changes in living cells and organisms presented in the well-known first edition. There are 16 new chapters and the 21 updated chapters in this new edition. They include advances in atomic force microscopy, structured illumination microscopy and other 3-D approaches, as well as imaging in single cells in animals and in plants. New analytical options include live high-throughput/high-content screening in mammalian cells and computational analysis of live cell data. The manual presents hands-on techniques as well as background material, and can serve as a text in advanced courses. The first section covers principles and fundamental issues of detection and imaging; the second provides detailed protocols for imaging live systems.

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Mouse Hematology: A Laboratory Manual

By Michael P. McGarry, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; Cheryl A. Protheroe, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; James J. Lee, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona

© 2010 • 100 pp., illus., appendix, index; poster; DVD
Paperback • $103.00 • ISBN 978-0-879698-86-7

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Mouse Hematology: A Laboratory Manual

By Michael P. McGarry, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; Cheryl A. Protheroe, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona; James J. Lee, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona

© 2010 • 100 pp., illus., appendix, index; poster; DVD
Hardcover • $169.00 • ISBN 978-0-879698-85-0