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Cell Survival and Cell Death

Edited By Eric H. Baehrecke, University of Massachusetts; Douglas R. Green, St. Jude Children's Research Hospital; Sally Kornbluth, Duke University; Guy S. Salvesen, Sanford-Burnham Medical Research Institute

Due August 2013 • 300 pp. (approx.), illus. (29 4C, 51 B&W), index
Hardcover • £85 • ISBN 978-1-936113-31-6

Cell death plays a critical role in development, normal physiology, and many diseases, including cancer. This short book describes our detailed understanding of the mechanisms involved in cell death signaling, covering signal transducers, caspases, Bcl2-family proteins, mitochondrial molecules, and IAPs, as well as the survival mechanisms that antagonize them. Cell death mechanisms involved in tumor suppression and cancer are also covered.

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Cell-Cell Junctions

Edited By W. James Nelson, Stanford University; Elaine Fuchs, The Rockefeller University

© 2010 • 443 pp., illus., index
Hardcover • £85.00 • ISBN 978-0-879698-84-3

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Clocks and Rhythms
(Cold Spring Harbor Symposia on Quantitative Biology LXXII)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2007 • 674 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • £39.00 £19.50 • ISBN 978-087969822-5

Based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.

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The Coiled Spring: How Life Begins

By Ethan Bier, University of California, San Diego
With an Introduction by Cliff Tabin, Harvard Medical School

© 2000 • 252 pp., illus., color plates, index, glossary, bibliography
Cloth • £8.00 £2.00 • ISBN 978-087969562-0

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Concerning the Origin of Malignant Tumours

By Theodor Boveri; Translated and annotated by Sir Henry Harris

© 2008 • 82 pp.
Paperback • £16.00 • ISBN 978-087969788-4

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • £196.00 • ISBN 978-087969861-4

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Control and Regulation of Stem Cells
(Cold Spring Harbor Symposia on Quantitative Biology LXXIIl)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Terri Grodzicker, Cold Spring Harbor Laboratory

© 2008 • 614 pp., illus., indexes
(Paperback edition does not include online access)
Paperback • £80.00 • ISBN 978-087969862-1

Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. 

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Cystic Fibrosis: A Trilogy of Biochemistry, Physiology, and Therapy

Edited By John R. Riordan, The University of North Carolina at Chapel Hill; Richard C. Boucher, The University of North Carolina at Chapel Hill; Paul M. Quinton, University of California, San Diego School of Medicine

Due July 2013 • 400 pp.(approx.), illus. (approx. 37 4C; 11 B&W), index
Hardcover • £85 £63.75 • ISBN 978-1-936113-34-7

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Davenport’s Dream: 21^st Century Reflections on Heredity & Eugenics

Edited By Jan A. Witkowski, Cold Spring Harbor Laboratory; John R. Inglis, Cold Spring Harbor Laboratory

© 2008 • 490 pp., illus.
Hardcover • £17.00 £8.50 • ISBN 978-087969756-3

In 1911, the influential geneticist Charles Davenport published Heredity in Relation to Eugenics, advancing his ideas of how genetics would improve society in the 20th century. It became a college textbook and a foundation for the widespread eugenics movement in the United States. Nearly 100 years later, many of the issues raised by Davenport are again being debated, in different guises. In this new volume, prominent academics discuss themes from Davenport’s book—human genetic variation, mental illness, nature vs. nurture, human evolution—in a contemporary context. Davenport’s original book is reprinted along with the essays. This book will be useful to historians of science as well as those interested in the social implications of human genetics research—past, present, and future.

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The Dawn of Human Genetics

By V.V. Babkov
Edited By James Schwartz; Translated from the Russian by Victor Fet

© 2013 • 775 pp., illus. (91 B&W ), index
Hardcover • £44 • ISBN 978-1-936113-70-5

In Russia, the initial euphoria of the Bolshevik leaders for a new socialist society ... combined with a commitment to a truly universal health care system, gave a huge boost to the emergence of both the eugenic and medical aspects of human genetics. The obstacles that proved so formidable to the successful launch of the field in the West—the lack of available data on the genealogy of diseases in families, the difficulty in getting a statistically significant number of identical twins to study, and the skepticism of the medical establishment—were all swept aside in the Soviet Union. In the 1920s ... the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world’s leading center for the study of the genetic basis of many diseases and human genetics in general. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov’s The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the “liquidation” of many of the country’s finest biologists, as well as a major setback to the development of world science. Like many other promising ideas and projects that were born in the Soviet Union, this one was abruptly truncated and then virtually eradicated.