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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Paperback • $167 $41.75 • ISBN 978-087969765-5

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Hardcover • $263 $65.75 • ISBN 978-087969764-8

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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The Development of Human Gene Therapy
(Cold Spring Harbor Monograph Series 36)

Edited By Theodore Friedmann, University of California, San Diego

© 1999 • 729 pp., illus., color plates, index
Cloth • $140 $35.00 • ISBN 978-087969528-6

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Gene Therapy: Fact and Fiction in Biology's New Approaches to Disease

By Theodore Friedmann, M.D., University of California, San Diego

© 1994 • 124 pp.
Paperback • $16 $6.40 • ISBN 978-087969446-3