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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $62.00 • ISBN 978-087969709-9

The Human Genome Project was completed in 2003, 50 years after the discovery of the structure of DNA and 17 years after an influential debate at the annual Cold Spring Harbor Laboratory Symposium about the Project’s feasibility. The 2003 Symposium was dedicated to examining what has been learned so far from the human genome sequence. This book contains over sixty contributions from the world’s leaders in this field and covers genome structure and evolution, methods of data analysis, lessons from species comparison, and the application of sequence data to the understanding of disease.

Purchasers of the hard cover edition of this book are entitled to access to the Symposia website at www.cshl-symposium.org. The site contains the full text of the written communications from the 2003 Symposium and the Symposia held in 1998 through 2002 (Volumes LXIII–LXVII). Subscribers to the site also gain access to archive photographs and selected papers from the 60–year history of the Annual Symposium.

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The Genome of Homo sapiens
(Cold Spring Harbor Symposia on Quantitative Biology LXVIII)

By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2003 • 544 pp., illus., appendices, index
(Paperback edition does not include online access)
Paperback • $126 $25.20 • ISBN 978-087969710-5

The Human Genome Project was completed in 2003, 50 years after the discovery of the structure of DNA and 17 years after an influential debate at the annual Cold Spring Harbor Laboratory Symposium about the Project’s feasibility. The 2003 Symposium was dedicated to examining what has been learned so far from the human genome sequence. This book contains over sixty contributions from the world’s leaders in this field and covers genome structure and evolution, methods of data analysis, lessons from species comparison, and the application of sequence data to the understanding of disease.

Purchasers of the hard cover edition of this book are entitled to access to the Symposia website at www.cshl-symposium.org. The site contains the full text of the written communications from the 2003 Symposium and the Symposia held in 1998 through 2002 (Volumes LXIII–LXVII). Subscribers to the site also gain access to archive photographs and selected papers from the 60–year history of the Annual Symposium.

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The Molecular Gaze: Art in the Genetic Age

By Suzanne Anker, School of Visual Arts, New York; Dorothy Nelkin, New York University

© 2004 • 216 pp., illus., index
Hardcover • $47 $23.50 • ISBN 978-087969697-9

The gene has become a cultural icon and an increasingly rich source of imagery and ideas for visual artists. Drawing on a wide range of contemporary painting and sculpture, The Molecular Gaze: Art in the Genetic Age explores the moral and bioethical questions these works address. What does it mean to be human? What is “identity” in a society of genetically manipulated individuals? Questions like these are growing louder as genetic technology advances and the public examines the ethical consequences more widely. Suzanne Anker and Dorothy Nelkin, an artist and a social scientist, have written a thought–provoking and visually fascinating book for scientists, artists, students, and general readers intrigued by the anxiety and exhilaration of the genetic age.

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The Unfit: A History of a Bad Idea

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2001 • 451 pp., illus., bibliography, indexes
Book of the Year for 2001 in Amazon's Professional Science Category!
Hardcover • $26 $6.50 • ISBN 978-087969587-3

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Times of Triumph, Times of Doubt: Science and the Battle for Public Trust

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2006 • 227 pp., index
Hardcover • $39 $15.60 • ISBN 978-087969805-8

The intent and uses of science are a continuing preoccupation, especially in public debates on issues such as new pharmaceuticals, cloning, stem cells, genetically modified foods, and assisted reproduction. Times of Triumph, Times of Doubt, written by the eminent geneticist and historian Elof Carlson, explores the moral foundations of science and their role in these hot–button issues. Carlson chooses a variety of case histories and describes their scientific background and the part played by scientists in the application of their work, including their motivations and reactions to bad outcomes, both real and alleged. He examines why ethical lapses have occurred in these areas, why bad things happen when, for the most part, those who worked on the science had only good intentions in mind, and how such lapses can be prevented from occurring in the future. This exploration of ethics and science is important reading for those interested in issues of science and society, including journalists, theologians, legislators, lawyers, and scientists themselves.

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Hardcover • $246.00 • ISBN 978-087969777-8

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition

By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; Stephen T. Smale, University of California, Los Angeles

© 2009 • 620 pp., appendix, index
Paperback • $169.00 • ISBN 978-087969762-4

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Translational Control in Biology and Medicine
(Cold Spring Harbor Monograph Series 48)

Edited By Michael B. Mathews, UMDNJ-New Jersey Medical School, Newark, New Jersey; Nahum Sonenberg, McGill University, Montreal, Canada; John W.B. Hershey, University of California, Davis

© 2007 • 934 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969767-9

The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

View two different sets of sample pages from the book here — and here —

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Type 1 Diabetes

Edited By Jeffrey A. Bluestone, University of California at San Francisco; Mark A. Atkinson, University of Florida, College of Medicine; Peter R. Arvan, University of Michigan Health System

© 2012 • 305 pp., illus., index
Hardcover • $135 • ISBN 978-1-936113-21-7

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.