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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Hardcover • $81.00 • ISBN 978-0-879698-87-4

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Means to an End: Apoptosis and Other Cell Death Mechanisms

By Douglas R. Green, St. Jude Children’s Research Hospital

© 2011 • 220 pp., additional reading, index
Paperback • $46.00 • ISBN 978-0-879698-88-1

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Mendel's Legacy: The Origin of Classical Genetics

By Elof Axel Carlson, Professor Emeritus, State University of New York at Stony Brook

© 2004 • 332 pp., illus., index
Hardcover • $47 $23.50 • ISBN 978-087969675-7

This latest book by Elof Carlson (The Unfit) is a first history of classical genetics, the era in which the chromosome theory of heredity was proposed and developed. Highly illustrated and based heavily on early 20th century original sources, the book traces the roots of genetics in breeding analysis and studies of cytology, evolution, and reproductive biology that began in Europe but were synthesized in the United States through new Ph.D. programs and expanded academic funding. Carlson argues that, influenced largely by new technologies and instrumentation, the life sciences progressed though incremental change rather than paradigm shifts, and he describes how molecular biology emerged from the key ideas and model systems of classical genetics. Readable and original, this narrative will interest historians and science educators as well as today's practitioners of genetics.

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Metabolism and Disease

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $318 • ISBN 978-1-936113-56-9

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Metabolism and Disease
(Cold Spring Harbor Symposia on Quantitative Biology LXXVI)

Edited By Terri Grodzicker, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2011 • 422 pp., illus., index
(Paperback edition does not include online access)
Paperback • $129 • ISBN 978-1-936113-57-6

This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

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Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

By David C. Amberg, Upstate Medical University, Syracuse; Daniel J. Burke, University of Virginia Medical Center, Charlottesville; Jeffrey N. Strathern, National Cancer Institute

© 2005 • 230 pp., illus., index
Paperback • $96.00 • ISBN 978-087969728-0

“Methods in Yeast Genetics” is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

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Mitochondria

Edited By Douglas C. Wallace, Children's Hospital of Philadelphia, University of Pennsylvania; Richard J. Youle, National Institute of Neurological Disorders and Strokes, Porter Neuroscience Research Center

Due September 2013 • 300 pp.(approx.), illus., index
Hardcover • $135 • ISBN 978-1-936113-35-4

Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mitochondrial components is implicated in numerous muscle and neurodegenerative disorders, including Parkinson’s disease. This volume contains contributions examining the evolution and normal function of mitochondria in cells, as well as their roles in various pathologies.

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Molecular Approaches to Controlling Cancer
(Cold Spring Harbor Symposia on Quantitative Biology LXX)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2005 • 538 pp., illus., index
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $62.00 • ISBN 978-087969773-0

The 2005 Cold Spring Harbor Symposium on Quantitative Biology focused on molecular strategies aimed at understanding and controlling the cancerous state. The resulting volume, with contributions from the world’s leading laboratories, covers many aspects of cancer genetics, including DNA repair, telomeres, animal models, stem cells, and therapeutic approaches.

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Molecular Approaches to Controlling Cancer
(Cold Spring Harbor Symposia on Quantitative Biology LXX)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory

© 2005 • 538 pp., illus., index
(Paperback edition does not include online access)
Paperback • $126 $25.20 • ISBN 978-087969774-7

The 2005 Cold Spring Harbor Symposium on Quantitative Biology focused on molecular strategies aimed at understanding and controlling the cancerous state. The resulting volume, with contributions from the world’s leading laboratories, covers many aspects of cancer genetics, including DNA repair, telomeres, animal models, stem cells, and therapeutic approaches.

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Molecular Biology of Aging
(Cold Spring Harbor Monograph Series 51)

Edited By Leonard P. Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas C. Wallace, University of California, Irvine

© 2008 • 610 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969824-9

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.