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Cell Survival and Cell Death

Edited By Eric H. Baehrecke, University of Massachusetts; Douglas R. Green, St. Jude Children's Research Hospital; Sally Kornbluth, Duke University; Guy S. Salvesen, Sanford-Burnham Medical Research Institute

Due August 2013 • 300 pp. (approx.), illus. (29 4C, 51 B&W), index
Hardcover • £85 • ISBN 978-1-936113-31-6

Cell death plays a critical role in development, normal physiology, and many diseases, including cancer. This short book describes our detailed understanding of the mechanisms involved in cell death signaling, covering signal transducers, caspases, Bcl2-family proteins, mitochondrial molecules, and IAPs, as well as the survival mechanisms that antagonize them. Cell death mechanisms involved in tumor suppression and cancer are also covered.

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Mammalian Development: Networks, Switches, and Morphogenetic Processes

Edited By Patrick P.L. Tam, Children’s Medical Research Institute; W. James Nelson, Stanford University; Janet Rossant, The Hospital for Sick Children

© 2013 • 520 pp., illus. (120 4C, 21 B&W), index
Hardcover • £98 • ISBN 978-1-936113-24-8

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The Endoplasmic Reticulum

Edited By Susan Ferro-Novick, University of California, San Diego; Tom A. Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

© 2013 • 336 pp., illus (61 4C, 9 B&W), index
Hardcover • £85 • ISBN 978-1-936113-82-8

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Wnt Signaling

Edited By Roel Nusse, Stanford University Medical Center; Xi He, Children’s Hospital Boston; Renée van Amerongen, Stanford University Medical Center

© 2013 • 454 pp., illus. (75 4C and 6 B&W), index
Hardcover • £85 • ISBN 978-1-936113-23-1

Wnt proteins are signaling molecules that play critical roles during embryonic development and in the regeneration of adult tissues. They bind to Frizzled and LRP family receptors on the cell surface, triggering a series of events that cause β-catenin to enter the nucleus and activate transcription factors that control cell fate and cell proliferation. Mutations in components of the Wnt pathway lead to developmental defects and are common in cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of canonical Wnt signaling, as well as β-catenin-independent Wnt signaling and cross-talk with other pathways. The contributors examine the numerous Wnt ligands; their production, secretion, and interactions with components of the extracellular environment; and details of the downstream signaling pathways that mediate the effects of Wnt proteins on cells. The roles of Wnt signaling in stem cell self-renewal, cell polarity, body-axis specification, wound healing, and other aspects of normal development and physiology are also covered.

This volume includes discussion of Wnt signaling in cancer, skeletal defects, neurological disorders, and other human disease states. Thus, it is an indispensable reference for cell and developmental biologists as well as those, especially in the fields of stem cell biology and regenerative medicine, who are interested in targeting the Wnt pathway for therapeutic purposes.

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Basic Stereology for Biologists and Neuroscientists

By Mark J. West, University of Aarhus, Denmark

© 2012 • 206 pp., illus., index
Hardcover • £44 • ISBN 978-1-936113-60-6

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Extracellular Matrix Biology

Edited By Richard O. Hynes, Massachusetts Institute of Technology; Kenneth M. Yamada, National Institutes of Health

© 2012 • 387 pp., illus. (62 4C and 5 B&W), index
Hardcover • £85.00 • ISBN 978-1-936113-38-5

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Angiogenesis: Biology and Pathology

Edited By Michael Klagsbrun, Children's Hospital Boston; Patricia D'Amore, Schepens Eye Research Institute

© 2011 • 522 pp., illus. (62 4C and 11 B&W), index
Hardcover • £85.00 • ISBN 978-1-936113-43-9

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Germ Cells

Edited By Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University; Robert Braun,  Jackson Laboratory

© 2011 • 222 pp., illus. (26 4C and 12 B&W images), index
Hardcover • £85.00 • ISBN 978-1-936113-51-4

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The Mammary Gland as an Experimental Model

Edited By Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; Jeffrey M. Rosen, Baylor College of Medicine

© 2011 • 325 pp., illus. (54 color, 5 b/w), index
Hardcover • £85.00 • ISBN 978-0-879699-06-2

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Neuronal Guidance: The Biology of Brain Wiring

Edited By Marc Tessier-Lavigne, The Rockefeller University; Alex L. Kolodkin, Johns Hopkins University School of Medicine

© 2011 • 397 pp., illus. (87 color, 6 b/w), index
Trim size: 7” x 10”
Hardcover • £85.00 £21.25 • ISBN 978-0-879698-97-3