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Gastrulation: From Cells to Embryo

Edited By Claudio D. Stern, University College London

© 2004 • 731 pp., illus., appendices, index
Printed hardcover • $158 $79.00 • ISBN 978-087969707-5

During gastrulation, tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.

Gene Function in Prokaryotes
(Cold Spring Harbor Monograph Series 15)

© 1983 • 328 pp., illus., index
Paperback • $37 $18.50 • ISBN 978-087969176-9

Gene Machines
(Enjoy Your Cells Series 4)

By Fran Balkwill; Mic Rolph

© 2002 • 32 fully illustrated 4-color pages
Paperback • $9.95 • ISBN 978-087969611-5

Gene Machines
(Enjoy Your Cells Series 4)

By Fran Balkwill; Mic Rolph

© 2002 • 32 fully illustrated 4-color pages
Hardcover • $14.95 • ISBN 978-087969616-0

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Gene Therapy: Fact and Fiction in Biology's New Approaches to Disease

By Theodore Friedmann, M.D., University of California, San Diego

© 1994 • 124 pp.
Paperback • $16 $6.40 • ISBN 978-087969446-3

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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Paperback • $167 $41.75 • ISBN 978-087969765-5

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Hardcover • $263 $65.75 • ISBN 978-087969764-8

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

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Generation and Interpretation of Morphogen Gradients

Edited By James Briscoe, MRC National Institute for Medical Research; Peter A. Lawrence, University of Cambridge, and MRC Laboratory of Molecular Biology; Jean-Paul Vincent, MRC National Institute for Medical Research

© 2010 • 308 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-0-879698-81-2

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

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Genes, Girls, and Gamow: After the Double Helix

By James D. Watson, Cold Spring Harbor Laboratory

© 2001 • 336 pp., 43 illus., 22 letters
NOTE: For distribution in the United States and Canada only.
Hardcover • $53 $26.50 • ISBN 978-037541283-7

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A Genetic Switch, Third Edition, Phage Lambda Revisited

By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York

© 2004 • 154 pp., illus., appendices, index
Paperback • $40.00 • ISBN 978-087969716-7

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.