More INFO on
this Product

Mammalian Development: Networks, Switches, and Morphogenetic Processes

Edited By Patrick P.L. Tam, Children’s Medical Research Institute; W. James Nelson, Stanford University; Janet Rossant, The Hospital for Sick Children

© 2013 • 520 pp., illus. (120 4C, 21 B&W), index
Hardcover • £98 • ISBN 978-1-936113-24-8

More INFO on
this Product

Immune Tolerance

Edited By Diane J. Mathis, Harvard Medical School; Alexander Y. Rudensky, Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center

© 2013 • 168 pp., illus. (2 B&W, 20 4C), index
Hardcover • £85 • ISBN 978-0-879698-95-9

More INFO on
this Product

DNA Replication

Edited By Stephen D. Bell, Indiana University, Bloomington; Marcel Méchali, Institute of Human Genetics, CNRS, Montpellier; Melvin L. DePamphilis, National Institutes of Health, Bethesda

© 2013 • 576 pp., illus. (88 4C, 33 B&W), appendices, index
Hardcover • £85 • ISBN 978-1-936113-48-4

More INFO on
this Product

The Dawn of Human Genetics

By V.V. Babkov
Edited By James Schwartz; Translated from the Russian by Victor Fet

© 2013 • 775 pp., illus. (91 B&W ), index
Hardcover • £44 • ISBN 978-1-936113-70-5

In Russia, the initial euphoria of the Bolshevik leaders for a new socialist society ... combined with a commitment to a truly universal health care system, gave a huge boost to the emergence of both the eugenic and medical aspects of human genetics. The obstacles that proved so formidable to the successful launch of the field in the West—the lack of available data on the genealogy of diseases in families, the difficulty in getting a statistically significant number of identical twins to study, and the skepticism of the medical establishment—were all swept aside in the Soviet Union. In the 1920s ... the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world’s leading center for the study of the genetic basis of many diseases and human genetics in general. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov’s The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the “liquidation” of many of the country’s finest biologists, as well as a major setback to the development of world science. Like many other promising ideas and projects that were born in the Soviet Union, this one was abruptly truncated and then virtually eradicated.

More INFO on
this Product

The Endoplasmic Reticulum

Edited By Susan Ferro-Novick, University of California, San Diego; Tom A. Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

© 2013 • 336 pp., illus (61 4C, 9 B&W), index
Hardcover • £85 • ISBN 978-1-936113-82-8

More INFO on
this Product

Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

© 2013 • 208 pp., illus. (78 4C, 5 B&W), index
Paperback • £28 • ISBN 978-1-936113-50-7

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

More INFO on
this Product

Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

By Gary D. Stormo, Ph.D.

© 2013 • 208 pp., illus. (78 4C, 5 B&W), index
Hardcover • £50 • ISBN 978-1-936113-49-1

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

More INFO on
this Product

Next-Generation DNA Sequencing Informatics

Edited By Stuart M. Brown, New York University School of Medicine

© 2013 • 241 pp., illus. (48 4C & 15 B&W), index
Hardcover • £41 • ISBN 978-1-936113-87-3

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data. The book also provides extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications. The book also includes reference to, and guidance on, the setup and use of essential software for NGS data analysis. This is the first book of its kind to address the informatics needs of scientists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.

More INFO on
this Product

Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

© 2013 • 704 pp., illus (3 4C, 606 B&W), index
Hardcover • £38 • ISBN 978-0-879698-59-1

The Annotated and Illustrated Double Helix

By James D. Watson, Cold Spring Harbor Laboratory; Alexander Gann, Cold Spring Harbor Laboratory; Jan Witkowski, Cold Spring Harbor Laboratory

© 2013 • 345 pages, illus. (320 B&W), index
Hardcover • £Not for Sale • ISBN 978-1-476715-49-0