More INFO on
this Product

Molecular Biology of Aging
(Cold Spring Harbor Monograph Series 51)

Edited By Leonard P. Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas C. Wallace, University of California, Irvine

© 2008 • 610 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969824-9

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.

More INFO on
this Product

Single-Molecule Techniques: A Laboratory Manual

Edited By Paul R. Selvin, University of Illinois, Urbana-Champaign; Taekjip Ha, University of Illinois, Urbana-Champaign

© 2008 • 507 pp., illus., appendix, index
Paperback • $169.00 • ISBN 978-087969775-4

More INFO on
this Product

Adult Neurogenesis
(Cold Spring Harbor Monograph Series 52)

Edited By Fred H. Gage, The Salk Institute for Biological Studies, San Diego, California; Gerd Kempermann, Center for Regenerative Therapies, Dresden, Germany; Hongjun Song, Johns Hopkins School of Medicine, Baltimore, Maryland

© 2008 • 673 pp., illus, index
Hardcover • $135 $67.50 • ISBN 978-087969784-6

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

More INFO on
this Product

Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Paperback • $167 $41.75 • ISBN 978-087969765-5

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

More INFO on
this Product

Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

Edited By Theodore Friedmann, University of California, San Diego; John Rossi, Beckman Research Institute of the City of Hope, Duarte, California

© 2007 • 793 pp., illus., appendix, index
Hardcover • $263 $65.75 • ISBN 978-087969764-8

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

More INFO on
this Product

Experimental Design for Biologists

By David J. Glass, M.D., Novartis Institutes for Biomedical Research, Cambridge, Massachusetts

© 2007 • 206 pp., illus., index
Hardcover • $37.00 $25.90 • ISBN 978-087969735-8

More INFO on
this Product

From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Paperback • $45 $22.50 • ISBN 978-087969738-9

More INFO on
this Product

From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Hardcover • $65 $32.50 • ISBN 978-087969737-2

More INFO on
this Product

Regulatory RNAs
(Cold Spring Harbor Symposia on Quantitative Biology LXXI)

Edited By Bruce Stillman, Cold Spring Harbor Laboratory, New York; David Stewart, Cold Spring Harbor Laboratory, New York

© 2006 • 574 pp., illus., indexes
(Hardcover edition includes online access; call for information and registration)
Hardcover • $310 $155.00 • ISBN 978-087969817-1

“Regulatory RNAs” was the theme of the 71st annual Cold Spring Harbor Symposium on Quantitative Biology, where scientists from around the world presented the latest advances in the biology of RNAs, including RNA interference, transcriptional and translational control, RNA editing, and the role of RNAs in biological circuits and epigenetic events. Investigators discussed the latest technologies aimed at large-scale characterization of RNAs, as well as the roles of small RNAs in development and cancer. This volume is a timely survey of this important new area of molecular biology.

More INFO on
this Product

Cell Biology of Addiction

Edited By Bertha K. Madras, Harvard Medical School; Christine M. Colvis, National Institute on Drug Abuse/NIH; Jonathan D. Pollock, National Institute on Drug Abuse/NIH; Joni L. Rutter, National Institute on Drug Abuse/NIH; David Shurtleff, National Institute on Drug Abuse/NIH; Mark von Zastrow, University of California, San Francisco

© 2006 • 465 pp., illus., appendices, index
Hardcover • $129 $32.25 • ISBN 978-087969753-2

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.