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The Skeletal System
(Cold Spring Harbor Monograph Series 53)

Edited By Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

© 2009 • 365 pp., illus., index
Hardcover • $95 $47.50 • ISBN 978-087969825-6

The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.

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The TGF-β Family
(Cold Spring Harbor Monograph Series 50)

Edited By Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

© 2008 • 1,114 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969752-5

TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the world’s leading laboratories to comprehensively cover all aspects of the biology of TGF-β and serve as a reference work for both specialists and researchers less familiar with the field.

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Molecular Biology of Aging
(Cold Spring Harbor Monograph Series 51)

Edited By Leonard P. Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas C. Wallace, University of California, Irvine

© 2008 • 610 pp., illus., index
Hardcover • $135 $67.50 • ISBN 978-087969824-9

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.

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Adult Neurogenesis
(Cold Spring Harbor Monograph Series 52)

Edited By Fred H. Gage, The Salk Institute for Biological Studies, San Diego, California; Gerd Kempermann, Center for Regenerative Therapies, Dresden, Germany; Hongjun Song, Johns Hopkins School of Medicine, Baltimore, Maryland

© 2008 • 673 pp., illus, index
Hardcover • $135 $67.50 • ISBN 978-087969784-6

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

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Invertebrate Neurobiology
(Cold Spring Harbor Monograph Series 49)

Edited By Geoffrey North, Editor of Current Biology; Ralph J. Greenspan, The Neurosciences Institute, San Diego, California

© 2007 • 665 pp., illus., index
Hardcover • $135 $33.75 • ISBN 978-087969819-5

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Translational Control in Biology and Medicine
(Cold Spring Harbor Monograph Series 48)

Edited By Michael B. Mathews, UMDNJ-New Jersey Medical School, Newark, New Jersey; Nahum Sonenberg, McGill University, Montreal, Canada; John W.B. Hershey, University of California, Davis

© 2007 • 934 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969767-9

The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.

View two different sets of sample pages from the book here — and here —

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DNA Replication and Human Disease
(Cold Spring Harbor Monograph Series 47)

Edited By Melvin L. DePamphilis, National Institutes of Health

© 2006 • 814 pp., illus., appendices, index
Hardcover • $139 $34.75 • ISBN 978-087969766-2

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Paperback • $59 $14.75 • ISBN 978-087969807-2

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969806-5

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The Dog and Its Genome
(Cold Spring Harbor Monograph Series 44)

Edited By Elaine A. Ostrander, National Human Genome Research Institute, NIH; Urs Giger, School of Veterinary Medicine, University of Pennsylvania, Philadelphia; Kerstin Lindblad-Toh, Broad Institute of MIT and Harvard

© 2006 • 584 pp., illus., index
Hardcover • $139 • ISBN 978-087969742-6

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.