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Yeast Intermediary Metabolism

By Dan G. Fraenkel, Harvard Medical School

© 2011 • 434 pp., illus. (138 b/w), appendix, index
Hardcover • $128 • ISBN 978-0-879697-97-6

The intermediary metabolism of small molecules is the meat and potatoes of cell function. The pathways and modes of obtaining energy, degradation and utilization of exogenous organic nutrients, and formation of the building blocks of the main macromolecules were a major focus of research in biology from the turn of the 20th century into the 1970s. Other matters have come to prominence, but the field is active, with interesting problems that are central to biology and medicine. Molecular biology developed through the use of one bacterium, Eschericha coli, with the saying “What’s true for E. coli is true for elephants.” In recent years, an analogous workhorse has been the eukaryotic microbe baker’s yeast, Saccharomyces cerevisiae, used in many studies of cell biology common to multicellular organisms. This book explains metabolism as based on Saccharomyces. The topics include central metabolic pathways; catabolism; fermentation; respiration; biosynthesis of small molecules including cofactors; the metabolism of lipids, polysaccharides, and storage molecules; inorganic ions; transport and compartments; the global analysis of metabolism; and issues of metabolic toxicity. It can be used in courses and as a reference book for research investigators.

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From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Paperback • $45 $22.50 • ISBN 978-087969738-9

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From a to α: Yeast as a Model for Cellular Differentiation

By Hiten D. Madhani, University of California, San Francisco

© 2007 • 115 pp., illus., index
Hardcover • $65 $32.50 • ISBN 978-087969737-2

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Landmark Papers in Yeast Biology

Edited By Patrick Linder, University of Geneva; David Shore, University of Geneva; Michael N. Hall, Biozentrum, University of Basel

© 2006 • 306 pp., index, CD
Printed hardcover • $99 $24.75 • ISBN 978-087969643-6

Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD.  The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology.  As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”

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Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

By David C. Amberg, Upstate Medical University, Syracuse; Daniel J. Burke, University of Virginia Medical Center, Charlottesville; Jeffrey N. Strathern, National Cancer Institute

© 2005 • 230 pp., illus., index
Paperback • $96.00 • ISBN 978-087969728-0

“Methods in Yeast Genetics” is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

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Lab Ref, Volume 1
A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench

Edited By Jane Roskams, University of British Columbia, Canada; Linda Rodgers, Cold Spring Harbor Laboratory

© 2002 • 272 pp., illus., appendices, index
Paperback • $25 • ISBN 978-1-936113-79-8

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The Early Days of Yeast Genetics

Edited By Michael N. Hall, Biozentrum der Universität Basel

© 1993 • 477 pp., illus., color plate, indexes
Paperback • $61.00 • ISBN 978-087969874-4