Due August 2012 • 300 pp. (approx.), index
Hardcover • $135 • ISBN  978-1-936113-32-3

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Parkinson’s Disease is an incurable neurodegenerative disease characterized by a progressive loss of dopaminergic neurons that leads to slowness of movement, muscle rigidity, and tremors. Insoluble aggregates of proteins such as alpha-synuclein accumulate in the affected neurons, which also appear to be subject to oxidative stress. This volume discusses recent work that has begun to uncover the molecular mechanisms that underlie the condition, including studies that implicate dysfunction of mitochondrial proteins such as parkin and pink1.

Preliminary

1. Introduction

Serge Przedborski

2. The History of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies

Christopher G. Goetz

3. Clinical Approach to Parkinson’s Disease: Features, Diagnosis, and Principles of Management

João Massano and Kailash P. Bhatia

4. Genetics of Parkinson’s Disease

Christine Klein and Ana Djarmati

5. Neuropathy

Dennis Dickson

6. Chemical Neuroanatomy

Jose Angel Obeso Inchausti

7. Functional Neuroimaging in Parkinson’s Disease

Martin Niethammer, Andrew Feigin, and David Eidelberg

8. Motor Control Abnormalities in Parkinson’s Disease

Pietro Mazzoni, Britne Shabbott, and Juan Camilo Cortes

9. Psysiological Phenotypes and Vulnerability in Parkinson’s Disease

D. James Surmeier, Jaime N. Guzman, Javier Sanchez, and Paul T. Schumacker

10. Modeling Parkinson’s Disease in Primates: The MPTP Model

Gregory Porras, Qin Li, and Erwan Bezard

11. A Guide to Neurotoxic Animal Models of Parkinson’s Disease

Kim Tieu

12. Animal Models: Vertebrate Genetics

Ted M. Dawson, Valina Dawson, and Yujong Lee

13. Animal Models: Invertebrate

Ming Guo

14. Mitochondrial Biology and Parkinson’s Disease

Celine Perier and Miquel Vila

15. Autophagy

Gary Buettner

16. The Role of Autophagy in Parkinson’s Disease

Melinda A. Lynch-Day, Kai Mao, Ke Wang, Mantong Zhao, and Daniel J. Klionsky

17. Programmed Cell Death

Katerina Venderova and David Park

18. Innate Inflammation in Parkinson’s Disease

V. Hugh Perry

19. Inflammation and Adaptive Immunity in Parkinson’s Disease

R. Lee Mosely, Jessica A. Hutter-Saunders, David K. Stone, and Howard E. Gendelman

20. Alpha-Synuclein in Parkinson’s Disease

Leonidas Stefanis

21. LRRK2 for Beginners: Six Key Questions

Lauren R. Kett and William T. Dauer

22. Parkinsonism due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitrochondrial Pathways

Mark R. Cookson

23. Protein Quality Control in Parkinson’s Disease

Casey Cook, Caroline Stetler, and Leonard Petrucelli

24. Parkinson’s Disease: Gene Therapies

Phillippe Coune, Bernard L. Schneider, and Patrick Aebischer

25. Bioinformatics

Howard Federoff

Index