Due August 2012 • 300 pp. (approx.), index
Hardcover • $135 • ISBN  978-1-936113-21-7

Sign up and login to receive our 10% member discount. Click Here to Register and Save

Discounts apply to direct purchases by individual U.S. and Canada customers only.

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as a genetic risk factors, animal models or diabetes, and new treatment strategies that are being developed.

Preliminary

1. The Pathogenesis and Natural History of Type 1 Diabetes

Mark A. Atkinson

2. Islet Autoantigens: Structure, Function, Localization, and Regulation

Peter Arvan, Massimo Pietropaolo, David Ostrov, and Christopher J. Rhodes

3. The Unfolded Protein Response in Beta-Cell Survival

Feroz Papa

4. Generating Beta-Cells from Stem Cells—The Story so Far

Matthias Hebrok

5. Virus Infections in Type 1 Diabetes

Ken T. Coppieters, Tobias Boettler, and Matthias von Herrath

6. Environmental Triggers of Type 1 Diabetes

Mikael Knip and Olli Simell

7. Methods, prediction and the effect of therapy of genetic, immunologic and metabolic Biomarkers of β cell destruction in the diagnosis of T1D

Jasmin Lebastchi and Kevan C. Herold

8. Clinical Interventions for the Treatment of T1D

Lucienne Chatenoud, Katharina Warncke, and Annette G. Ziegler

9. Connecting Type 1 and Type 2 Diabetes Through Innate Immunity

Justin I. Odegaard and Ajay Chawla

10. Genetics of Type 1 Diabetes

Janelle A. Noble and Henry A. Erlich

11. Humoral Autoimmunity and the Prediction of Type-1 Diabetes

Massimo Pietropaolo, Roberto Towns, and George S. Eisenbarth

12. Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice

Michael A. Brehm, Alvin C. Powers, Leonard D. Shultz, and Dale L. Greiner

13. Do MHCII-Presented Neo-Antigens Drive Type-1 Diabetes and Other Autoimmune Diseases?

Philippa Marrack and John W. Kappler

14. Antigen-Specific Therapeutic Approaches in Type 1 Diabetes

Xavier Clement-Casares, Sue Tsai, Carol Huang, and Pere Santamaria

15. Antigen Targets of Type 1 Diabetes Autoimmunity

Bart O. Roep and Mark Peakman

16. The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes

Jean-François Bach and Lucienne Chatenoud

17. Breakdown in Peripheral Tolerance in Type 1 Diabetes

Lukas T. Jeker, Hélène Bour-Jordan, and Jeffrey A. Bluestone

18. Update on Islet Transplantation

Michael McCall and A. M. James Shapiro

Index