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Genes, Girls, and Gamow: After the Double Helix

By James D. Watson, Cold Spring Harbor Laboratory

© 2001 • 336 pp., 43 illus., 22 letters
NOTE: For distribution in the United States and Canada only.
Hardcover • $53 $26.50 • ISBN 978-037541283-7

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A Genetic Switch, Third Edition, Phage Lambda Revisited

By Mark Ptashne, Sloan-Kettering Memorial Cancer Center, New York

© 2004 • 154 pp., illus., appendices, index
Paperback • $40.00 • ISBN 978-087969716-7

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

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Genetic Variation: A Laboratory Manual

Edited By Michael P. Weiner, RainDance Technologies, Inc., Guilford, Connecticut; Stacey B. Gabriel, The Broad Institute, Massachusetts Institute of Technology, Cambridge; J. Claiborne Stephens, Motif BioSciences, New York

© 2007 • 472 pp., illus., appendix, index
Paperback • $165 • ISBN 978-087969780-8

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Genetics of Complex Human Diseases: A Laboratory Manual

Edited By Ammar Al-Chalabi, MRC Centre for Neurodegeneration Research, King’s College London; Laura Almasy, Southwest Foundation for Biomedical Research, San Antonio, Texas

© 2009 • 220 pp., illus., index
Paperback • $97.00 • ISBN 978-087969883-6

Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

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Genetics of Complex Human Diseases: A Laboratory Manual

Edited By Ammar Al-Chalabi, MRC Centre for Neurodegeneration Research, King’s College London; Laura Almasy, Southwest Foundation for Biomedical Research, San Antonio, Texas

© 2009 • 220 pp., illus., index
Hardcover • $162.00 • ISBN 978-087969882-9

Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

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Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes

By David Micklos, Cold Spring Harbor Laboratory; Bruce Nash, Cold Spring Harbor Laboratory; Uwe Hilgert, University of Arizona

© 2013 • 704 pp., illus (3 4C, 606 B&W), index
Hardcover • $55 • ISBN 978-0-879698-59-1

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Hardcover • $139 $34.75 • ISBN 978-087969806-5

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Genomes
(Cold Spring Harbor Monograph Series 46)

Edited By Hillary E. Sussman, Cold Spring Harbor Laboratory; Maria A. Smit, Cold Spring Harbor Laboratory

© 2006 • 475 pp., illus., index
Paperback • $59 $14.75 • ISBN 978-087969807-2

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George Beadle, An Uncommon Farmer: The Emergence of Genetics in the 20th Century

By Paul Berg, Stanford University School of Medicine; Maxine Singer, Carnegie Institution of Washington

© 2005 • 383 pp., illus., index
Paperback • $21 $10.50 • ISBN 978-087969763-1

George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize–winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.

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Germ Cells

Edited By Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University; Robert Braun,  Jackson Laboratory

© 2011 • 222 pp., illus. (26 4C and 12 B&W images), index
Hardcover • $135 • ISBN 978-1-936113-51-4