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Malaria: Biology in the Era of Eradication

Subject Area(s):  Human Biology and Disease

Edited by Dyann Wirth, Harvard School of Public Health; Pedro Alonso, University of Barcelona

Due January 2017 • 350 pages (approx.), illustrated, index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-22-9
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Malaria is a mosquito-borne disease caused by parasitic protozoa that belong to the genus Plasmodium. This disease imposes a significant global health burden, claiming the lives of several thousand children and pregnant women each day. Increasing antimalarial drug resistance and the complexity of the Plasmodium life cycle, among other factors, have made eradication difficult.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biology, pathology, and epidemiology of malaria, as well as ongoing efforts to treat infections and manage their spread. Contributors discuss the Plasmodium life cycle, focusing on the molecular mechanisms by which the various parasitic stages induce clinical symptoms, interact with the immune system, and lead to further transmission of malaria. They also explore topics such as the interaction between mosquito reproduction and Plasmodium development, epigenetic regulation of malaria-associated genes, and unique features of malaria in pregnant women (e.g., parity-dependent susceptibility) and describe how an improved understanding of these phenomena may lead to novel intervention strategies.

The driving forces behind antimalarial drug resistance are covered, as is progress in developing an effective vaccine and controlling mosquito populations. This volume is therefore an essential reference for all scientists, clinicians, and public health professionals interested in understanding malaria and reducing its devastating effects.


Malaria Transmission and Prospects for Malaria Eradication: The Role of the Environment
Marcia C. Castro
Determinants of Malaria Transmission at the Population Level
Teun Bousema and Chris Drakeley
Biology of Malaria Transmission
Elamaran Meibalan and Matthias Marti
The Biology of Plasmodium vivax
John H. Adams and Ivo Mueller
Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control
Sara N. Mitchell and Flaminia Catteruccia
Modern Vector Control
Neil F. Lobo, Nicole L Achee, John Greico, and Frank H. Collins
Current and Future Prospects for Preventing Malaria Transmission Via the Use of Insecticides
Hilary Ranson
Plasmodium Sporozoite Biology
Friedrich Frischknecht and Kai Matuschewski
Malaria Parasite Liver Infection and Exo-Erythrocytic Biology
Ashley M. Vaughan and Stefan H.I. Kappe
Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes
Shailja Singh and Chetan E. Chitnis
Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination
Caeul Lim, Selasi Dankwa, Aditya S. Paul, and Manoj T. Duraisingh
Immune Responses in Malaria
Carole A. Long and Fidel Zavala
Malaria Pathogenesis
Danny A. Milner Jr.
Malaria During Pregnancy
Michal Fried and Patrick E. Duffy
Malaria Genomics in the Era of Eradication
Daniel E. Neafsey and Sarah K. Volkman
Malaria Epigenetics
Alfred CortÚs and Kirk W. Deitsch
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Didier Menard and Arjen Dondorp
Vaccines to Accelerate Malaria Elimination and Eventual Eradication
Julie Healer, Alan F. Cowman, David C. Kaslow, and Ashley J. Birkett
Malaria Modeling in the Era of Eradication
Thomas A. Smith, Nakul Chitnis, Melissa Penny, and Marcel Tanner