Click to Enlarge

Add To Cart

The TGF-β Family

(Cold Spring Harbor Monograph Series 50)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Developmental BiologyCell BiologyHuman Biology and DiseaseBiochemistryCancer Biology

Edited by Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

© 2008 • 1,114 pp., illus., index
Hardcover • $135 67.50 (click here to price in UK Pounds)
ISBN  978-087969752-5
You save: 50%
Discounts apply to direct website purchases by individual US customers only; all sales are final.

  •     Description    
  •     Contents    
  •     Reviews    
  •     Related Titles    

Contents

Preface
Foreword
M.B. Sporn

1. The Discovery of TGF-β: A Historical Perspective
H.L. Moses and A.B. Roberts
2. TGF-β and the TGF-β Family
R. Derynck and M. Miyazono

CELL BIOLOGY
3. TGF-β: A Multipotential Cytokine
S.H. Schilling, A.B. Hjelmeland, J.N. Rich, and X.-F. Wang
4. Activins and Inhibins
E. Wiater and W. Vale
5. The Bone Morphogenetic Proteins
T. Katagiri, T. Suda, and K. Miyazono

SIGNALING
6. Signaling Receptors of the TGF-β Family
J.L. Wrana, B. Ozdamar, C. Le Roy, and H. Benchabane
7. TGF-β Bioavailability: Latency, Targeting, and Activation
B. Dabovic and D.B. Rifkin
8. Agonists and Antagonists of the TGF-β Family Ligands
C. Chang
9. TGF-β Signaling from Receptors to Smads
C.-H. Heldin
10. Transcriptional Control via Smads
X. Lin, Y.-G. Chen, and X.-H. Feng
11. Growth Control by TGF-β: Mechanisms Controlling Cell Cycle Progression and Apoptosis
P.M. Siegel and J. Massagué
12. Regulation of TGF-β Family Signaling by Inhibitory Smads
K. Miyazono
13. Structural Basis for TGF-β Family Receptor Assembly and Signaling Specificity
K. Lin and S. Choe
14. Non-Smad TGF-β Signaling Pathways
Y.E. Zhang
15. Regulation of the Smad Pathway by Signaling Cross-Talk
K. Luo

DIFFERENTIATION, DEVELOPMENT, AND PHYSIOLOGY
16. TGF-β Family Signaling in Early Postimplantation Development of the Mouse
S. Miura, M. Whitman, and Y. Mishina
17. TGF-β Family Signaling in Drosophila
G. Pyrowolakis, B. Hartmann, and M. Affolter
18. TGF-β Signaling in the Nematode C. elegans
G.I. Patterson and R.W. Padgett
19. TGF-β Family Signaling in Xenopus and Zebrafish Embryos
M. Whitman
20. TGF-β Family Signaling in Stem Cell Renewal and Differentiation
T. Watabe and K. Miyazono
21. TGF-β Family Signaling in Mesenchymal Differentiation
R. Derynck, E. Piek, R.A. Schneider, L. Choy, and T. Alliston
22. TGF-β Family Signaling in Skeletal Development, Maintenance, and Disease
T. Alliston, E. Piek, and R. Derynck
23. TGF-β Family in Epithelial Development
N.M. Muñoz and W.M. Grady
24. The TGF-β Family in Endothelial Cell Differentiation and Cardiovascular Development and Function
M.-J. Goumans, R. Carvalho, C. Mummery, and P. ten Dijke
25. TGF-β as a Regulator of Myeloid and Lymphoid Development and Function
J.J. Letterio and F.W. Ruscetti
26. The TGF-β Family in Neural and Neuronal Differentiation and Development
J. Samanta, M.A. Bonaguidi, and J.A. Kessler
27. The TGF-β Family in the Reproductive Tract
S.A. Pangas and M.M. Matzuk

CANCER AND DISEASE
28. TGF-β Signaling Pathway and Tumor Suppression
W.M. Grady and S.D. Markowitz
29. TGF-β Signaling in Epithelial–Mesenchymal Transition and Invasion and Metastasis
R.J. Akhurst
30. TGF-β and the Tumor Microenvironment
B. Bierie and H.L. Moses
31. TGF-β and Fibrosis
E.P. Böttinger
32. Development of TGF-β-based Therapeutic Agents: Capitalizing on TGF-β’s Mechanisms of Action and Signal Transduction Pathways
C.L. Arteaga and J.M. McPherson
33. BMP-based Therapeutics and the BMP Signaling Pathways
G. Bain, A.J. Celeste, and J.M. Wozney

Index

Reviews

review:  “The breadth and depth of the coverage of current TGF-β research is the most compelling feature of this book...[I]t is my recommendation that every principal investigator studying TGF-β should have a copy of this book...[T]he process of ‘getting up to speed’ becomes far less arduous.”
      —Development

review:  “The book includes numerous figures and tables, which make each chapter accessible and pleasant to read. This volume will be of interest both for basic scientists concerned with topics such as transcriptional control of TFG-β signaling, as well as for translational scientists and clinicians focused on agents used to target the TGF-β signaling pathway...In summary, this book can be considered as a true TGF-β family encyclopedia.”
      —The Quarterly Review of Biology

review:  “I found The TGF-β Family a great book. Tables and illustrations will surely prove useful in guiding the reader through complex problems and the book can be certainly recommended for teaching purposes. The clarity and comprehensiveness of the monograph, the eminence of the editors and authors, and the extensive bibliography at the end of each chapter make this book a ‘must-have’ reference for established investigators and clinicians and for newcomers attracted to TGF-β from various fields.”
      —Nature Cell Biology

Related Titles

You may be interested in these related titles:

Drosophila: A Laboratory Handbook, Second Edition
$200
Manipulating the Mouse Embryo: A Laboratory Manual (Third Edition)
$169
Gastrulation: From Cells to Embryo
$158 $142.20