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April 2008 |
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April Sale Cold Spring Harbor Protocols Bench Marks — The CSH Protocols Blog Editors'
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Sale Shelf 2008 Cold Spring Harbor Laboratory Meetings & Courses Jobs at Cold Spring Harbor Laboratory Lowest Prices on the Web and Special Offers — Did you know that buying directly from CSHL Press enables you to receive the best price for any new title we publish? Our “Gold Member” discount prices are frequently lower than any other online site – including Amazon. As a Gold Member, you will also be the first to hear about new titles arriving in our warehouse and be selected to receive special offers for Gold Members only. For complete details, click click here. For all inquiries, problems, or suggestions regarding this e-Newsletter, please click here. |
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Davenport’s Dream: 21st Century Reflections on Heredity & Eugenics When Charles Davenport published Heredity in
Relation to Eugenics in 1911, he advanced his ideas
of where genetics would go in the rest of the 20th century. In this
volume, a group of prominent scientists take some of Davenport's
themes—mental illness, human evolution, nature and nurture—and
discuss them in a 21st-century context. Davenport's original book
is reprinted along with the essays. |
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Neither Gods Nor Beasts: How Science Is Changing Who We Think We Are Traditional views of human nature focus on the supernatural, defining us as creatures with souls and spirits that transcend our physical attributes. In this provocative book, distinguished scientist and historian Elof Axel Carlson argues for a more scientific view of human nature, one that is based on our biology—our cellular organization, genetics, life cycle, and evolution. Carlson challenges educators, the media, and public policy makers to integrate science more fully into our understanding of ourselves. |
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Grounds for Knowledge: A Guide to Cold Spring Harbor Laboratory's Landscapes and Buildings Grounds for Knowledge is an engaging and knowledgeable guide to CSHL's buildings both historic and new, and to the 150 species of trees that surround them. The superb color photography and detailed maps invite exploration of the newly designated Bungtown Botanical Garden. Buildings and landscapes of nearby Lab campuses in Woodbury, Lloyd Harbor, and Cold Spring Harbor village are covered as well. |
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Life Illuminated: Selected Papers from Cold Spring Harbor, Volume 2 (1972-1994) This book is the second volume of an intellectual history of the science done at CSHL (the first volume, Illuminating Life, showed that genetics became the dominant theme of research at CSH by as early as 1904). The appointment of James Watson as Director of the Laboratory in 1968 set off the explosive research development at CSH, as he recruited widely and wisely teams of investigators with diverse scientific interests. From this collection of papers, presented in full on the accompanying CD, several themes emerge: the characterization and exploitation of mobile genetic elements; the mechanics of DNA replication and regulation of the cell cycle; the behavior and internal architecture of cells; how viruses induce tumors; the discovery of cancer genes; the characteristics of neurons; and the invention of techniques that make possible further progress. Each theme is introduced in the context of the science of the time, and each paper has a commentary by, in most cases, one of its authors. |
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A Short Guide to the Human Genome How many genes are in the human genome? Which genes are commonly associated
with genetic diseases? How many mobile elements, simple sequence repeats,
or protein kinases are encoded in the genome? How similar are human
proteins to those of mouse, yeast, or bacteria? |
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“What is epigenetics? Asking that question will likely return a number of answers that are all some variation of ‘heredity that is not due to changes in DNA sequence.’ In other words, epigenetics is not genetics. That seems a definition as indistinct as U.S. Supreme Court Justice Potter Stewart’s statement, ‘I know it when I see it,’ about obscenity. The recent volume, Epigenetics, provides well-needed clarity by setting down the fundamental concepts and principles of this emerging science... With the publication of Epigenetics, this fascinating scientific field no longer needs to be defined by what it is not.” —The Quarterly Review of Biology Note that illustrations from Epigenetics are freely available for download at www.genesandsignals.com/epigenetics! |
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April showers bring major
discounts! The following history of science books will be discounted
25% until April 30th. |
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The Eighth Day of Creation: The Makers of the Revolution in Biology (25th Anniversary Edition) |
Won for All: How the Drosophila Genome Was Sequenced |
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Freely available methods to screen genomes and analyze evolution This month's issue of Cold Spring Harbor Protocols highlights a method for screening the mouse genome using ENU mutagenesis. The method, "Mouse Mutagenesis Using N-ethyl-N-nitrosourea (ENU)," was submitted by Monica Justice and colleagues from the Baylor College of Medicine. This protocol is freely available here. The second protocol, available here, is a guide for selecting the proper method for analyzing evolutionary relationships between genes. To enjoy access to the entire collection of methods in Cold Spring Harbor Protocols, subscribe today! Free trials are available. Ask your librarian to request a trial for your institution or use our convenient online form. Submit to CSH Protocols! CSH Protocols also welcomes your new and improved protocols — click here to view our online manuscript submission instructions. Cold Spring Harbor Protocols |
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Bench Marks is a blog kept by David Crotty, the Executive Editor of CSH Protocols. |
April's issue of CSH Protocols features a set of articles on the production and use of retroviral vectors for gene transfer from Kenneth Cornetta, Karen Pollok, and Dusty Miller. "Retroviral Vectors for Gene Transfer" provides an overview of the subject, drawing on the more than twenty years of experience researchers have with the use of these vectors. The advantages of retroviral vectors are detailed (efficiency, integration, and ease of production) along with the disadvantages (inactivation, a requirement for cell division, and possible oncogenic activation). The authors discuss important aspects of vector design and choice of packaging cell lines. Four protocols are provided, two for production of viral vectors, and two for their use in transducing cells. Detailed methods are offered for retroviral vector production by transient transfection, and for the generation of stable vector-producing cells. Once vectors are generated, they can easily be used to transduce cell lines which are actively proliferating. However, using retroviral vectors with primitive progenitor or stem cells, which are not continuously dividing, is much less efficient. In "Transduction of Primary Hematopoietic Cells by Retroviral Vectors," the authors describe two interventions to improve efficiency of transfer: the use of cytokines and other growth factors to stimulate cell cycling, and the use of matrix proteins to mediate colocalization of target cells and vector. |
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The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis
and is a potential 1p36 tumor suppressor. |
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Protein networks in disease. |
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GABAA receptors determine the temporal dynamics of memory retention. |
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Design
of a highly specific and noninvasive biosensor suitable for real-time in
vivo imaging of mercury(II) uptake. |
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Hammerhead Redux: Does the new structure fit the old biochemical data? |
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To enjoy complete access
to these essential journals, please recommend a subscription to your library
with this convenient online form:
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| At the Bench: A Laboratory Navigator, Updated Edition Binding and Kinetics for Molecular Biologists Molecular Biology of the Gene, Sixth Edition Lab Ref, Volume 2: A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench |
Single-Molecule Techniques: A Laboratory Manual Bioinformatics: Sequence and Genome Analysis, Second Edition |
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Sold and distributed in the Americas by CSHL Press. Histological and Histochemical Methods, Fourth Edition By John Kiernan, The University of Western Ontario, London, Ontario, Canada The chemical and physical principles of fixation, staining, and histochemistry are now in one volume! Now in its fourth edition, Histological and Histochemical Methods has been expanded and updated with the latest techniques and developments within the field, whilst retaining the details of the classic techniques still in use. The relations of chemical structures and reactions to fixation, tissue processing, staining, enzyme location, immunohistochemistry, and other procedures are explained in simple, descriptive terms. This book is recommended for lecturers and students in biological and biomedical disciplines using histological and histochemical techniques. Postgraduate researchers will find this to be the ideal laboratory companion, as will medical laboratory technologists preparing for their professional examinations. Clinical Biochemistry, Second Edition By Richard Luxton, University of the West of England, Bristol, UK Clinical Biochemistry focuses on the areas of body function required for the maintenance of health, including input, control, processing, transport and storage, and defense and output. This new edition has been substantially revised and updated and incorporates the latest developments in genomics, proteomics, and biosensors to ensure the reader is up to date with the subject. The book also benefits from an improved design and layout to aid student understanding. |
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| Visit our Sale Shelf where you will find steeply discounted laboratory manuals, textbooks, and monographs! Don’t miss this opportunity to add exceptional books to your professional library at price reductions of 50% or more. Quantities are limited, so don’t delay — stock up now! Click HERE. | |||||||||||||||
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The Dolan DNA Learning Center (DNALC) is the world's first science center devoted entirely to genetics education. |
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Cold Spring Harbor Laboratory is a private, nonprofit institution for research and education in the biological sciences. The Lab is internationally recognized for its excellence in research in cancer, neurobiology, plant genetics, and bioinformatics, and offers a broad range of educational programs for professional scientists and scientists-in-training, from elementary school students to Nobel laureates. Check the job listings below for opportunities to become a part of this important institution. Animal Technician |
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Save 10% on future purchases from our website Register today at www.cshlpress.com and join the Gold Member Discount Program! Gold Members receive 10% discounts on all website purchases. Take a minute to sign up and you can save on all your favorite CSHL Press books. This offer is just too good to pass up! |
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