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In this issue:  • New and Forthcoming TitlesMedicine Review Articles FREEHistoric Moments FREE
 • Journal Editors’ Selected Articles FREE • Biology Review Articles FREE • Essential Protocols FREE

 
A Bioinformatics Guide for Molecular Biologists - The Cure for Informatics Anxiety Molecular Neuroscience: A Laboratory Manual - New! Pre-order for September Save 20% on Quickstart Molecular Biology with Free Shipping in the US and Canada! Experimental Design for Biologists, Second Edition - Updated Classic Signal Transduction - Essential Reference

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Evolution cover image

Basic Methods in Protein Purification and Analysis: A Laboratory Manual cover image

Mouse Hematology: A Laboratory Manual cover image

Imaging: A Laboratory Manual cover image

Evolution
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Basic
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Imaging:
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Imaging in Neuroscience: A Laboratory Manual cover image

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An Introduction to Animal Behavior: An Integrative Approach cover image

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New and Forthcoming Titles

Quick Start Molecular Biology: An Introductory Course for Mathematicians, Physicists, and Engineers  cover image
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Quickstart Molecular Biology: An Introductory Course for Mathematicians, Physicists, and Engineers

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This book is an introductory course in molecular biology for mathematicians, physicists, and engineers. It covers the basic features of DNA, proteins, and cells but in the context of recent technological advances, such as next generation sequencing and high-throughput screens, and their applications. This enables readers to move rapidly from the basics to an understanding of cutting-edge research in systems biology and genomics.

Immunity and Tolerance
(Cold Spring Harbor Symposia on Quantitative Biology LXXVIII) cover image
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Immunity and Tolerance
(Cold Spring Harbor Symposia on Quantitative Biology LXXVIII)

The 78th Symposium spans a broad range of approaches towards increased understanding of the immune system including genetics, biochemistry, molecular and cell biology, and developmental biology. Fundamental biological discoveries are balanced with applications relevant to societal wellbeing including a variety of stratagems for harnessing the immune system to treat disease.

A Bioinformatics Guide for Molecular Biologists cover image
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A Bioinformatics Guide for Molecular Biologists

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The editors of this book approach the field of bioinformatics from the viewpoint of a molecular biologist, (1) arming the biologist with a basic understanding of the fundamental concepts in the field, (2) presenting approaches for using the tools from the standpoint of the data for which they are created, and (3) showing how the field of informatics is quickly adapting to the advancements in biology and biomedical technologies. It is a must-read for those interested in learning informatics techniques required for successful research and development in the laboratory.

Experimental Design for Biologists, Second Edition cover image
Now Available!

Experimental Design for Biologists, Second Edition

This handbook explains how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. This thoroughly updated edition is an essential source of theory and practical guidance for designing a research plan.

Molecular Neuroscience: A Laboratory Manual cover image
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Molecular Neuroscience: A Laboratory Manual

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This laboratory manual serves as a comprehensive practical guide to molecular and cellular step-by-step methods for neuroscientists, detailing fundamental and advanced techniques for working with cells, DNA, RNA, gene transfer, and imaging. The techniques included in this manual were developed in the Advanced Techniques in Molecular Neuroscience course offered annually at Cold Spring Harbor Laboratory, as well as protocols drawn from its best-selling lab manuals. It is an essential resource for all neuroscientists, from graduate students upward, who seek to use molecular techniques to probe the complexities of the nervous system. Click here to see the full protocols TOC.

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Genetics and Biology of Sexual Conflict

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Battles between the sexes occur at the genetic level when traits that would be advantageous for one sex are disadvantageous for the other. This book discusses the basis for this sexual conflict and its role as a driver of evolution.

Reviews

Manipulating the Mouse Embryo: A Laboratory Manual, Fourth Edition cover image

Manipulating the Mouse Embryo: A Laboratory Manual, Fourth Edition

“The editors...should be praised once again for a brilliant work done, accommodating the latest techniques in mouse embryo manipulation, while not forgetting the traditional procedures that must be learnt properly by anyone joining this field of animal transgenesis for the first time.”

—International Society for Transgenic Technologies Blog

Manipulating the Mouse Embryo: A Laboratory Manual, Fourth Edition cover image

Endocytosis

“A seminal body of outstanding medical scholarship, Endocytosis is an essential addition to academic library Medical Studies reference collections, and will prove to be of immense interest and value to cell biologists, neuroscientists, immunologists, developmental biologists, microbiologists, and anyone with a professional or personal interest in the physiological and therapeutic implications of endocytosis as a key cellular process.”

—Library Bookwatch

 

Journal Editors’ Selected Articles
The articles below were specially selected by our journal editors and are freely available to read.

Cold Spring Harbor Protocols cover image Cold Spring Harbor Protocols

Measuring Apoptosis: Caspase Inhibitors and Activity Assays.
Gavin P. McStay and Douglas R. Green
doi: 10.1101/pdb.top070359.

Preparation of Rough Microsomes from Rat Liver.
David D. Sabatini
doi: 10.1101/pdb.prot079970.

Genes & Development cover image Genes & Development

Evolutionally dynamic L1 regulation in embryonic stem cells.
Nathaly Castro-Diaz, Gabriela Ecco, Andrea Coluccio, Adamandia Kapopoulou, Benyamin Yazdanpanah, Marc Friedli, Julien Duc, Suk Min Jang, Priscilla Turelli, and Didier Trono
Vol. 28 (13) 1397–1409.

piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.
Dubravka Pezic, Sergei A. Manakov, Ravi Sachidanandam, and Alexei A. Aravin
Vol. 28 (13) 1410–1428.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.
Jinu Abraham, Yaiza Nuñez-Álvarez, Simone Hettmer, Elvira Carrió, Hung-I Harry Chen, Koichi Nishijo, Elaine T. Huang, Suresh I. Prajapati, Robert L. Walker, Sean Davis, Jennifer Rebeles, Hunter Wiebush, Amanda T. McCleish, Sheila T. Hampton, Christopher R.R. Bjornson, Andrew S. Brack, Amy J. Wagers, Thomas A. Rando, Mario R. Capecchi, Frank C. Marini, Benjamin R. Ehler, Lee Ann Zarzabal, Martin W. Goros, Joel E. Michalek, Paul S. Meltzer, David M. Langenau, Robin D. LeGallo, Atiya Mansoor, Yidong Chen, Mònica Suelves, Brian P. Rubin, and Charles Keller
Vol. 28 (14) 1578–1591.

Genome Research cover image Genome Research

Analysis of 41 plant genomes supports a wave of successful genome duplications in association with the Cretaceous-Paleogene boundary.
Kevin Vanneste, Guy Baele, Steven Maere, and Yves Van de Peer
Vol. 24 (8) 1334–1347.

This month Genome Research published a study examining ancient whole genome duplication events in 41 different plant species. Using whole genome and transcriptome sequencing, the authors were able to determine that the plants had duplication events clustering with the Cretaceous-Paleogene mass extinction. This event, occurring roughly 66 million years ago, is associated with the loss of about 75% of the species on Earth, including dinosaurs. The authors propose that stress and extinction may have promoted the establishment of polyploid species, which contain more than two sets of chromosomes. The study is profiled on GenomeWeb’s The Daily Scan.

Leraning & Memory cover image Learning & Memory

A novel role for the rat retrosplenial cortex in cognitive control.
Andrew J.D. Nelson, Emma L. Hindley, Josephine E. Haddon, Seralynne D. Vann, and John P. Aggleton
Vol. 21 (2) 90–97.

RNA cover image RNA

Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate.
Takamasa Hirano, Yuka W. Iwasaki, Zachary Yu-Ching Lin, Masanori Imamura, Naomi M. Seki, Erika Sasaki, Kuniaki Saito, Hideyuki Okano, Mikiko C. Siomi, and Haruhiko Siomi
Vol. 20 (8) 1223–1237.

 

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Neuronal Guidance: The Biology of Brain Wiring cover image

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Neuronal
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Cell-Cell
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Clocks and Rhythms cover art

Won for All: How the <em>Drosophila</em> Genome Was Sequenced cover art

Times of Triumph, Times of Doubt: Science and the Battle for Public Trust cover art

Molecular
Biology
of Aging
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Clocks and
Rhythms
$310 $155
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Won for All:
How the
Drosophila
Genome Was
Sequenced
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Times of Doubt:
Science and
the Battle for
Public Trust
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Human Variation:
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How to manage your lab (not). A new post from Kathy Weston graphic

 

bioRχiv (pronounced "bioarchive") is a not-for-profit, electronic preprint service for life scientists offered by Cold Spring Harbor Laboratory. bioRχiv provides authors with the opportunity to present drafts of scientific papers that have not yet been published in a peer-reviewed journal. Preprints in all aspects of biological and biomedical research are invited. There is no charge for submission.

bioRχiv (pronounced "bioarchive") is a not-for-profit, electronic preprint service for life scientists offered by Cold Spring Harbor Laboratory. bioRχiv provides authors with the opportunity to present drafts of scientific papers that have not yet been published in a peer-reviewed journal. Preprints in all aspects of biological and biomedical research are invited. There is no charge for submission.

Watch video here.

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CSH Perspectives logo image Cold Spring Harbor Perspectives in Medicine


A New Type of Review Journal in Molecular Medicine

CSH Perspectives cover image Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect.

Read these essential papers in this month’s issue:

Understanding glaucoma: Gareth Howell breaks down the complex neuroinflammatory processes.
Astrocytes, microglia, and other cell types mediate neuroinflammatory processes in the retina and optic nerve head during the early stages of glaucoma. Inhibiting certain proinflammatory pathways may be neuroprotective. Read more.

Joe Heitman and colleagues describe sexual reproduction in human fungal pathogens.
Many pathogenic fungi, including Cryptococcus, Candida, and Aspergillus, have sexual or parasexual cycles. Some unions involve closely related individuals; others involve diverse individuals and the capacity for significant gene flow. Read more.

Treating skin cancer: Tony Oro on advanced therapies for basal cell carcinoma.
Traditional therapies (e.g., surgical excision) are used for many patients with sporadic basal cell carcinoma (BCC). The Hedgehog pathway inhibitor vismodegib (Erivedge) is used for advanced BCCs, but more drugs must be developed. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more.

Cold Spring Harbor Perspectives in Medicine
Expert Reviews in Molecular Medicine
www.cshmedicine.org

 

CSH Monographs logo imageThe CSH Monograph Archive

The Complete, Renowned Book Series Now Online!

From the Preface of Volume 15: Gene Function in Prokaryotes:
In June of 1982, a meeting was held at the Banbury Center of Cold Spring Harbor Laboratory in honor of the memory of Luigi Gorini. The participants heard speakers whose research was in the areas that Luigi had pioneered during his career. Out of this meeting has evolved this volume, which covers not only these research areas but several others at the forefront of bacterial genetics. Read more.

The Cold Spring Harbor Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive's 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.

It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.

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Cold Spring Harbor Monograph Archive
www.cshmonographs.org
59 Volumes, One Complete Archive

 

CSH Perspectives logo imageCold Spring Harbor Perspectives in Biology

A New Type of Online Review Journal

CSH Perspectives cover image• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:

Pascale Cossart and Ari Helenius describe how microbes use endocytic machinery to infect host cells.
Viral and bacterial pathogens often use host cells as protected sites for replication. Some exploit the endocytic machinery to gain entry into the cytosol. Read more.

The evolution of aging: Margo Adler and Russell Bonduriansky on the role of sexual conflict.
Sexual conflict can affect the evolution of life span and aging, and vice versa. Empirical exploration of these ideas is only beginning. Read more.

Iain Cheeseman reviews the central roles of the kinetochore during mitosis.
During mitosis, the chromosomes are tethered to spindle microtubule polymers via a kinetochore. Careful assembly and regulation of these macromolecular structures are key to ensuring that chromosome segregation occurs with high fidelity. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here.

Cold Spring Harbor Perspectives in Biology
www.cshperspectives.org
The Authoritative View

 

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