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In this issue:  • New and Forthcoming TitlesMedicine Review Articles FREEHistoric Moments FREE
 • Journal Editors’ Selected Articles FREE • Biology Review Articles FREE • Essential Protocols FREE

Editor's Pick – Just Released! Signal Transduction - Save 20%! With Free Shipping in the US and Canada. Limited time only.
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Next-Generation DNA Sequencing Informatics cover image

Live Cell Imaging: A Laboratory Manual, Second Edition cover image

Single-Molecule Techniques: A Laboratory Manual cover image

Statistics at the Bench: A Step-by-Step Handbook for Biologists cover image

Next-Generation DNA Sequencing Informatics
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Essentials of Glycobiology, Second Edition cover image

Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques, Second Edition cover image

C. elegans Atlas cover image

Drosophila Neurobiology: A Laboratory Manual cover image

Essentials of Glycobiology, Second
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Transcriptional Regulation in Eukaryotes: Concepts, Strategies,
and Techniques, Second Edition
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C. elegans
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Drosophila Neurobiology:
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Guide to the Human Genome cover image

A Short
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Guide to the
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New and Forthcoming Titles

Signal Transduction cover image
Now Available!
20% off, Limited Time Offer!


Signal Transduction

This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes.

  • Introduces the fundamental principles of signal transduction
  • Provides ‘route maps’ for all the major signaling pathways
  • Explains in detail how signaling pathways are integrated to control key cellular process

Myc and the Pathway to Cancer cover image
Now Available!


MYC and the Pathway to Cancer

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression.

Origin and Evolution of Eukaryotes cover image
Now Available!


Origin and Evolution of Eukaryotes

Eukaryotes—organisms whose cells possess a nucleus and internal membranes—first appeared on earth around two billion years ago, when one prokaryotic cell engulfed another. The resulting cells went on to give rise to all fungi, animals, and plants. This book discusses the evolutionary processes that led to the appearance of eukaryotes and how they subsequently evolved.

Signal Transduction cover image
Now Available!

Father to Son

At the age of 24, James Watson had a scientific discovery to his credit—the structure of DNA—that would win a Nobel Prize and forever change our understanding of genes and inheritance. Now, after a lifetime of accomplishment in research, writing, education, and science advocacy, Watson has delved for the first time publicly into his own lineage to chronicle an archetypical American family from before the Civil War to Vietnam. With its portraits of many memorable characters, illustrated with previously unpublished photographs and period documents, Father To Son brilliantly illuminates the fundamental truth that who we become as individuals is determined by both our genetic and cultural heritage.

Now Available on Kindle!

Visit the Father to Son website here.

Connecting with Companies cover image
Now Available!


Connecting with Companies: A Guide to Consulting Agreements for Biomedical Scientists

An essential guide for academic scientists and physicians who are considering consulting work in biomedicine

By Edward Klees, J.D., General Counsel at the University of Virginia Investment Management Company; H. Robert Horvitz, Ph.D., 2002 Nobel Laureate in Physiology or Medicine; Professor of Biology, MIT; Member, McGovern Institute for Brain Research, MIT; Member, Koch Institute for Integrative Cancer Research, MIT; Investigator, Howard Hughes Medical Institute

Before signing a consulting agreement, this must-have reference will help you understand the key issues to consider—from intellectual property, confidentiality, and compensation, to often overlooked issues such as indemnity, different classes of stock, and the relevance of insider trading and securities laws.

Connecting with Companies is an invaluable resource for students, staff, and faculty. To assist you with ordering multiple copies for your institution, we’ve set up convenient discount order options.

Now Available on Kindle!

For more information visit Bioagreements.org

The Skin and Its Diseases cover image
Due This Month!


The Skin and Its Diseases

This book examines the cells that make up the skin and their functions, as well as diseases such as psoriasis that affect the skin and new molecular strategies for treating these.

Quick Start Molecular Biology: An Introductory Course for Mathematicians, Physicists, and Engineers  cover image
Due Next Month!


Quickstart Molecular Biology: An Introductory Course for Mathematicians, Physicists, and Engineers

This book is an introductory course in molecular biology for mathematicians, physicists, and engineers. It covers the basic features of DNA, proteins, and cells but in the context of recent technological advances, such as next generation sequencing and high-throughput screens, and their applications. This enables readers to move rapidly from the basics to an understanding of cutting-edge research in systems biology and genomics.

 

Journal Editors’ Selected Articles
The articles below were specially selected by our journal editors and are freely available to read.

Cold Spring Harbor Protocols cover image Cold Spring Harbor Protocols

Translating Intracellular Calcium Signaling into Models
Ruediger Thul
doi: 10.1101/pdb.top066266.

Investigating Physical Chromatin Associations across the Xenopus Genome by Chromatin Immunoprecipitation
George E. Gentsch and James C. Smith
doi: 10.1101/pdb.prot080614.

Genes & Development cover image Genes & Development

Stress-induced cleavage of Myc promotes cancer cell survival.
Maralice Conacci-Sorrell, Celine Ngouenet, Sarah Anderson, Thomas Brabletz, and Robert N. Eisenman
Vol. 28 (7) 689–707.

Genome Research cover image Genome Research

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.
Henne Holstege, Wayne Pfeiffer, Daoud Sie, Marc Hulsman, Thomas J. Nicholas, Clarence C. Lee, Tristen Ross, Jue Lin, Mark A. Miller, Bauke Ylstra, Hanne Meijers-Heijboer, Martijn H. Brugman, Frank J.T. Staal, Gert Holstege, Marcel J.T. Reinders, Timothy T. Harkins, Samuel Levy, and Erik A. Sistermans
Vol. 24 (5) 733-742.

Predicting the virulence of MRSA from its genome sequence.
Maisem Laabei, Mario Recker, Justine K. Rudkin, Mona Aldeljawi, Zeynep Gulay, Tim J. Sloan, Paul Williams, Jennifer L. Endres, Kenneth W. Bayles, Paul D. Fey, Vijaya Kumar Yajjala, Todd Widhelm, Erica Hawkins, Katie Lewis, Sara Parfett, Lucy Scowen, Sharon J. Peacock, Matthew Holden, Daniel Wilson, Timothy D. Read, Jean van den Elsen, Nicholas K. Priest, Edward J. Feil, Laurence D. Hurst, Elisabet Josefsson, and Ruth C. Massey
Vol. 24 (5) 839-849.

This month Genome Research published a study examining the genetics of MRSA virulence. Using genome sequences from 90 MRSA infections, the authors identified over one hundred genetic regions associated with toxicity. Highly toxic strains of MRSA leading to severe disease could be predicted from the genome sequence alone, potentially personalizing treatment of an infection. This study was profiled in Nature and Nature Genetics.

Also in this issue is a study examining the accumulation of mutations in the healthy blood cells of a 115-yr-old woman. Whole genome sequencing identified over 400 mutations in white blood cells that were not found in her brain, and analysis of mutation frequencies suggests her blood derived from only two active hematopoietic stem cells, hinting at potential limits of human longevity. This study was profiled in New Scientist and TIME.

Leraning & Memory cover image Learning & Memory

A novel role for the rat retrosplenial cortex in cognitive control.
Andrew J.D. Nelson, Emma L. Hindley, Josephine E. Haddon, Seralynne D. Vann, and John P. Aggleton
Vol. 21 (2) 90–97.

RNA cover image RNA

miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure.
Henrik Sperber, Alan Beem, Sandra Shannon, Ross Jones, Pratyusha Banik, Yu Chen, Sherman Ku, Gabriele Varani, Shuyuan Yao, and Hannele Ruohola-Baker
Vol. 20 (5) 621-631.

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Genetics of
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Gene Transfer:
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Generation and Interpretation of Morphogen Gradients cover art

Evolution: The Molecular Landscape cover art

Davenport’s Dream: 
21st Century Reflections on Heredity & Eugenics cover art

Symmetry
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Generation
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Heredity & Eugenics
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Human Variation: A Genetic Perspective on Diversity, Race, and Medicine cover image Retinal Disorders: Genetic Approaches to Diagnosis and Treatment cover image The Genetics and Biology of Sexual Conflict cover image

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Retinal Disorders:
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What's the point of doing a PhD? A new post from Kathy Weston graphic

 

bioRχiv (pronounced "bioarchive") is a not-for-profit, electronic preprint service for life scientists offered by Cold Spring Harbor Laboratory. bioRχiv provides authors with the opportunity to present drafts of scientific papers that have not yet been published in a peer-reviewed journal. Preprints in all aspects of biological and biomedical research are invited. There is no charge for submission.

bioRχiv (pronounced "bioarchive") is a not-for-profit, electronic preprint service for life scientists offered by Cold Spring Harbor Laboratory. bioRχiv provides authors with the opportunity to present drafts of scientific papers that have not yet been published in a peer-reviewed journal. Preprints in all aspects of biological and biomedical research are invited. There is no charge for submission.

Watch video here.

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CSH Perspectives logo image Cold Spring Harbor Perspectives in Medicine


A New Type of Review Journal in Molecular Medicine

CSH Perspectives cover image Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect.

Read these essential papers in this month’s issue:

Cracking cancer’s complexities: Louis Staudt on the molecular basis of Burkitt lymphoma.
Burkitt lymphoma is a germinal center B-cell-derived cancer that was instrumental in the identification of MYC as an important human oncogene more than three decades ago. Recently, new genomics technologies have uncovered several additional oncogenic mechanisms that cooperate with MYC to create this highly aggressive cancer. Read more.

David Sachs describes the use of mixed chimerism to induce organ transplantation tolerance.
“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This state is usually attained through either bone marrow or mobilized peripheral blood stem cell transplantation. Read more.

Poring over sweat glands: Elaine Fuchs on the homeostasis and repair of glandular skin.
The human body is covered with several million sweat glands. These tiny coiled tubular skin appendages produce the sweat that is our primary source of cooling and hydration of the skin. Numerous studies have been published on their morphology and physiology. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more.

Cold Spring Harbor Perspectives in Medicine
Expert Reviews in Molecular Medicine
www.cshmedicine.org

 

CSH Perspectives logo imageThe CSH Monograph Archive

The Complete, Renowned Book Series Now Online!

From the Preface of Volume 14: Nucleases:
In August 1981, at the suggestion of Jim Watson, a meeting was held at Cold Spring Harbor on the topic of nucleases. The idea was to bring together people who study these enzymes, but who do not usually meet as a group because their individual interests in nucleases are primarily in the context of some other field. Historically, nucleases have not usually been considered a field in their own right, rather they have been studied because of their role in some particular biological phenomena such as the four R’s—Replication, Recombination, Repair, and Restriction.

The Cold Spring Harbor Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive's 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.

It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.

CSH Monograph book covers image

Cold Spring Harbor Monograph Archive
www.cshmonographs.org
59 Volumes, One Complete Archive

 

CSH Perspectives logo imageCold Spring Harbor Perspectives in Biology

A New Type of Online Review Journal

CSH Perspectives cover image• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:

Mark Lemmon and colleagues highlight the unique properties of the EGFR family.
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases (RTKs) for which ligand binding was studied and for which the importance of ligand-induced dimerization was established. Read more.

Clathrins up close: Tom Kirchhausen details the components of clathrin-coated vesicles.
Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. Read more.

Tony Hunter describes the origin and evolution of tyrosine phosphorylation research.
Tyrosine phosphorylation of proteins was discovered in 1979, but this posttranslational modification had been “invented” by evolution more than a billion years ago in single-celled eukaryotic organisms that were the antecedents of the first multicellular animals. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here.

Cold Spring Harbor Perspectives in Biology
www.cshperspectives.org
The Authoritative View

 

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Get 100s of Free Protocols from the World's Leading Methods Journal

Click here to access 100s of free protocols available at Cold Spring Harbor Protocols.

 

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