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In this issue:  • New and Forthcoming TitlesMedicine Review Articles FREEHistoric Moments FREE
 • Journal Editors’ Selected Articles FREE • Biology Review Articles FREE • Essential Protocols FREE

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Antibodies: A Laboratory Manual, Second edition cover art

Antibodies:
A Laboratory Manual,
Second edition
$175 $113.75
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Lab Ref, Volume 1, A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench cover art

Lab Ref
Volume 1
A Handbook
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RNA: A Laboratory Manual
$169 $109.85
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RNA Worlds: From Life's Origins to Diversity in Gene Regulation cover art

RNA Worlds:
From Life’s Origins to Diversity
in Gene
Regulation
$162 $105.30
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At the Bench: A Laboratory Navigator, Updated Edition cover art

At the
Bench:
A Laboratory Navigator, Updated
Edition
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Experimental Design for Biologists
$37 $24.05
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Basic Methods in Protein Purification and Analysis: A Laboratory Manual cover art

Basic
Methods
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and Analysis:
A Laboratory Manual
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Means to an End: Apoptosis and Other Cell Death Mechanisms cover art

Means to
an End: Apoptosis
and Other
Cell Death Mechanisms

$46 $29.90
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Yeast
Intermediary
Metabolism
$128 $83.20
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Calcium Signaling
$135 $87.75
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New and Forthcoming Titles

Connecting with Companies cover image
Now Available!


Connecting with Companies: A Guide to Consulting Agreements for Biomedical Scientists

An essential guide for academic scientists and physicians who are considering consulting work in biomedicine

By Edward Klees, J.D., General Counsel at the University of Virginia Investment Management Company; H. Robert Horvitz, Ph.D., 2002 Nobel Laureate in Physiology or Medicine; Professor of Biology, MIT; Member, McGovern Institute for Brain Research, MIT; Member, Koch Institute for Integrative Cancer Research, MIT; Investigator, Howard Hughes Medical Institute

Before signing a consulting agreement, this must-have reference will help you understand the key issues to consider—from intellectual property, confidentiality, and compensation, to often overlooked issues such as indemnity, different classes of stock, and the relevance of insider trading and securities laws.

Connecting with Companies is an invaluable resource for students, staff, and faculty. To assist you with ordering multiple copies for your institution, we’ve set up convenient discount order options.

Endocytosis cover image
Now Available!


Endocytosis

Cells are surrounded by a plasma membrane that serves as a conduit for signaling and all interactions between cells and their environment. This volume from Cold Spring Harbor Perspectives in Biology describes the multiple mechanisms that mediate endocytosis and regulate the trafficking and sorting of macromolecular cargo along a complex endocytic pathway. Endocytosis enables selective uptake, controls the protein composition of the plasma membrane and plays essential roles in cell physiology, development and human disease.

Signal Transduction cover image
Due This Month!


Father to Son

At the age of 24, James Watson had a scientific discovery to his credit—the structure of DNA—that would win a Nobel Prize and forever change our understanding of genes and inheritance. Now, after a lifetime of accomplishment in research, writing, education, and science advocacy, Watson has delved for the first time publicly into his own lineage to chronicle an archetypical American family from before the Civil War to Vietnam. With its portraits of many memorable characters, illustrated with previously unpublished photographs and period documents, Father To Son brilliantly illuminates the fundamental truth that who we become as individuals is determined by both our genetic and cultural heritage.

Signal Transduction cover image
Due Next Month!


Signal Transduction

This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes.

Myc and the Pathway to Cancer cover image
Due This Spring!
Special Pre-Publication Pricing!


MYC and the Pathway to Cancer

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression.

Origin and Evolution of Eukaryotes cover image
Due This Spring!
Special Pre-Publication Pricing!


Origin and Evolution of Eukaryotes

This book discusses the evolutionary processes that led to the appearance of eukaryotes and how they subsequently evolved.

The Skin and Its Diseases cover image
Due This Spring!
Special Pre-Publication Pricing!


The Skin and Its Diseases

This book examines the cells that make up the skin and their functions, as well as diseases such as psoriasis that affect the skin and new molecular strategies for treating these.

 

Rebalancing cancer research. A new post from Kathy Weston graphic

 

Journal Editors’ Selected Articles
The articles below were specially selected by our journal editors and are freely available to read.

Cold Spring Harbor Protocols cover image Cold Spring Harbor Protocols

Patch-Clamp Recording of Voltage-Sensitive Ca2+ Channels
María A Gandini, Alejandro Sandoval, and Ricardo Felix
doi: 10.1101/pdb.top066092.

Electrophoretic Mobility Shift Assays for RNA-Protein Complexes
Donald C. Rio
doi: 10.1101/pdb.prot080721.

Genes & Development cover image Genes & Development

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.
Nobuhiro Okada, Chao-Po Lin, Marcelo C. Ribeiro, Anne Biton, Gregory Lai, Xingyue He, Pengcheng Bu, Hannes Vogel, David M. Jablons, Andreas C. Keller, J. Erby Wilkinson, Biao He, Terry P. Speed, and Lin He
Vol. 28 (5) 438–450.

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Vanja Pekovic-Vaughan, Julie Gibbs, Hikari Yoshitane, Nan Yang, Dharshika Pathiranage, Baoqiang Guo, Aya Sagami, Keiko Taguchi, David Bechtold, Andrew Loudon, Masayuki Yamamoto, Jefferson Chan, Gijsbertus T.J. van der Horst, Yoshitaka Fukada, and Qing-Jun Meng
Vol. 28 (6) 548–560.

Genome Research cover image Genome Research

Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
Derek Spieler, Maria Kaffe, Franziska Knauf, José Bessa3, Juan J. Tena, Florian Giesert, Barbara Schormair, Erik Tilch, Heekyoung Lee, Marion Horsch, Darina Czamara, Nazanin Karbalai, Christine von Toerne, Melanie Waldenberger, Christian Gieger, Peter Lichtner, Melina Claussnitzer, Ronald Naumann, Bertram Müller-Myhsok, Miguel Torres, Lillian Garrett, Jan Rozman, Martin Klingenspor, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Johannes Beckers, Sabine M. Hülter, Thomas Meitinger, Stefanie M. Hauck, Helmut Laumen, Wolfgang Wurst, Fernando Casares, Jose Luis Gómez-Skarmeta, and Juliane Winkelmann
Vol. 24 (4) 592-456.

This month Genome Research published a study of a common genetic variant implicated in Restless Legs Syndrome (RLS). The variant is located in the noncoding region of a gene called MEIS1 and can alter expression in the future basal ganglia, a region of the brain associated with coordinating motor movement. This study represents the first indication that RLS has origins in embryonic development, and also highlights the multiple approaches that may be necessary to identify physiological implications of other disease-associated genetic variants. The study was featured by ScienceDaily and Medical Xpress. More information on this study can be found on our website.

Leraning & Memory cover image Learning & Memory

A novel role for the rat retrosplenial cortex in cognitive control.
Andrew J.D. Nelson, Emma L. Hindley, Josephine E. Haddon, Seralynne D. Vann, and John P. Aggleton
Vol. 21 (2) 90–97.

RNA cover image RNA

An atlas of chromatoid body components.
Oliver Meikar, Vasily V. Vagin, Frédéric Chalmel, Karin Sõstar, Aurélie Lardenois, Molly Hammell, Ying Jin, Matteo Da Ros, Kaja A. Wasik, Jorma Toppari, Gregory J. Hannon, and Noora Kotaja
Vol. 20 (4) 483-495.

 

CSH Protocols logo artCold Spring Harbor Protocols

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Neuronal Guidance: The Biology of Brain Wiring cover image

Neuronal
Guidance:
The Biology
of Brain Wiring
$135 $67.50
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The Origins of Life cover art

The Origins
of Life
$135 $67.50
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Cell-Cell
Junctions
$35 $67.50
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The Skeletal System
$95 $47.50
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Adult
Neurogenesis
$135 $67.50
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Life Illuminated: Selected Papers from Cold Spring Harbor Volume 2, 1972–1994 cover art

Life Illuminated:
Selected Papers
from Cold
Spring Harbor
Volume 2,
1972-1994
$39 $19.50
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Clocks and Rhythms
$310 $155
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Landmark Papers in Yeast Biology cover art

Landmark
Papers in
Yeast Biology
$99 $24.75
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Signal
Transduction
$165 $132

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Human
Variation:
A Genetic
Perspective
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Race, and
Medicine
$59 $47.20

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MYC
and the
Pathway to
Cancer
$135 $108

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The Skin and
Its Diseases
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108
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Origin and Evolution of Eukaryotes cover image

Origin and Evolution
of Eukaryotes
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108
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Molecular Cloning: A Laboratory Manual
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$365 30% off, now $255.50

Biorxiv-The Preprint Server for Biology

 

CSH Perspectives logo image Cold Spring Harbor Perspectives in Medicine


A New Type of Review Journal in Molecular Medicine

CSH Perspectives cover image Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect.

Read these essential papers in this month’s issue:

Cracking cancer’s complexities: Louis Staudt on the molecular basis of Burkitt lymphoma.
Burkitt lymphoma is a germinal center B-cell-derived cancer that was instrumental in the identification of MYC as an important human oncogene more than three decades ago. Recently, new genomics technologies have uncovered several additional oncogenic mechanisms that cooperate with MYC to create this highly aggressive cancer. Read more.

David Sachs describes the use of mixed chimerism to induce organ transplantation tolerance.
“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This state is usually attained through either bone marrow or mobilized peripheral blood stem cell transplantation. Read more.

Poring over sweat glands: Elaine Fuchs on the homeostasis and repair of glandular skin.
The human body is covered with several million sweat glands. These tiny coiled tubular skin appendages produce the sweat that is our primary source of cooling and hydration of the skin. Numerous studies have been published on their morphology and physiology. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more.

Cold Spring Harbor Perspectives in Medicine
Expert Reviews in Molecular Medicine
www.cshmedicine.org

 

CSH Symposia logo artThe CSH Symposia
70 Year Online Archive

Historic Moments in Molecular Biology

Antibodies, Vol. XXXII photo

Replication of DNA in
Microorganisms, Vol. XXXIII

(CSH Symposium, Vol. XXXIII, 1968)

In his foreword to the 1968 Symposium volume, John Cairns describes a state of affairs (“...the exact mechanism of DNA duplication has become more rather than less obscure with the passage of time”) similar to that lamented by Demerec in 1951 (“...the large body of information accumulated since 1941 has made geneticists less certain than ever about the physical properties of genes”) Read more.

Hundreds of important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia. These meetings, held each year on the tranquil grounds of one of the world's leading research institutes, have been notable events in biomedical research since 1933.  Now this essential archive, dating from 1933 to 2003, is available online. Among highly influential volumes is the 1968 meeting “Replication of DNA in Microorganisms, Vol. XXXIII”, above is an excerpt from the exclusive new online introduction to this volume. Read more.

 

CSH Perspectives logo imageCold Spring Harbor Perspectives in Biology

A New Type of Online Review Journal

CSH Perspectives cover image• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:

Rosalind Segal describes how neurons use the endosomal system for long-distance signaling.
The distinctive morphology of neurons, with complex dendritic arbors and extensive axons, presents spatial challenges for intracellular signal transduction. The endosomal system provides mechanisms that enable signaling molecules initiated by extracellular cues to be trafficked throughout the expanse of the neuron, allowing intracellular signals to be sustained over long distances. Read more.

The emergence of eukaryotes: Andy Knoll examines the geologic record for evolutionary clues.
Eukaryotic organisms radiated in Proterozoic oceans with oxygenated surface waters, but, commonly, anoxia at depth. Exceptionally preserved fossils of red algae favor crown group emergence more than 1200 million years ago, but older (up to 1600–1800 million years) microfossils could record stem group eukaryotes. Read more.

Denise Barlow and Marisa Bartolomei on epigenetic mechanisms underlying genomic imprinting.
Genomic imprinting affects a subset of genes in mammals and results in a monoallelic, parental-specific expression pattern. Most of these genes are located in clusters that are regulated through the use of insulators or long noncoding RNAs (lncRNAs). Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here.

Cold Spring Harbor Perspectives in Biology
www.cshperspectives.org
The Authoritative View

 

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