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In This Issue

January 2012

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New and Forthcoming Titles
Cold Spring Harbor Perspectives in Medicine
 
Pre-Publication Sale—25% off!
Books in the Media—Outstanding Academic Title recognition! 
New Year's Sale—Extraordinary 50% Savings!
Download Kindle Books—additional title now available!
Journal Editors’ Selected Articles
Sale Shelf: Many New Additions
Cold Spring Harbor Perspectives in Biology
Cold Spring Harbor Symposia Archive
Current Bestsellers
Bench Marks
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Job Opportunities
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Cold Spring Harbor Laboratory’s
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  View sample pages for these titles by clicking on the links below

Imaging: A Laboratory Manual cover imageNew Kindle Edition! graphic
Imaging: A Laboratory Manual goes electronic!

FREE SAMPLE!

The Kindle version of this must-have resource for molecular biologists is now available in electronic format (via Kindle app) for your iPad, iPhone, Android, Windows PC, Mac, Windows Phone 7, Blackberry, or Kindle device! Imaging: A Laboratory Manual is the cornerstone of our new laboratory manual series on imaging techniques, which have become tremendously valuable in nearly every field of biological research. This volume is designed as a general reference and describes the theory and practice of a wide array of imaging methods, but becomes an even more effective research tool in an electronic format. Visit the Kindle Store and download the free sample material to see for yourself how this manual comes to life with live links and beautiful full-color illustrations.

 

HIV: From Biology to Prevention and Treatment cover imageNow Available! graphic

HIV: From Biology to Prevention and Treatment

This book provides a comprehensive review of HIV research, covering everything from the pathogenesis of HIV infection to prevention. Contributors explore the origins and evolution of HIV, the HIV replication cycle, host–virus interactions, host immune responses, and HIV transmission. Vaccines, cell and gene therapies, antiretroviral drugs, microbicides, and behavioral strategies for the treatment and prevention of HIV infections are also explored.

HIV research tops Science’s list of advances in 2011!
Science’s Breakthrough of the Year: HIV Prevention as Treatment.

A clinical trial, HPTN 052, finds that antiretroviral drugs can be used to dramatically lower the risk of transmitting HIV. HIV: From Biology to Prevention and Treatment, is a timely and valuable review of HIV research, and includes a complete section on Therapy and Prevention.

 

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The Biology of Alzheimer Disease

This comprehensive volume includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Experts in the field discuss the biochemistry and cell biology of amyloid β-protein precursor (APP), tau, presenilin, β-secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis.

 

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Angiogenesis: Biology and Pathology

This volume reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered.

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Did you know that buying directly from CSHL Press enables you to save money on any title we publish? As a member of our Discount Program, you will enjoy prices that are frequently lower than those of any other online site – including Amazon. Regardless of where you make your purchase, all revenue from sales of CSHL Press publications supports research at Cold Spring Harbor Laboratory. However, when you buy directly from our website, you provide a greater level of assistance. As a member of our Discount Program, you will also be the first to hear about new titles arriving in our warehouse and will receive exclusive special offers. For complete details, click here.

 
 

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CSH Perspectives cover imageA New Type of Review Journal in Molecular Medicine

Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect.

Read these essential papers in this month’s issue:

A vaccine for AIDS: Gary Nabel on developing immunogens that generate broadly neutralizing antibodies to HIV-1.
The development of a highly effective AIDS vaccine will likely depend on success in designing immunogens that elicit broadly neutralizing antibodies to naturally circulating strains of HIV-1. Although the antibodies induced after natural infection with HIV-1 are often directed to strain-specific or nonneutralizing determinants, it is now evident that 10%–25% of HIV-infected individuals generate neutralizing antibody responses of considerable breadth. Read more.

The genetics of diabetes: Janelle Noble and Henry Erlich review the loci associated with susceptibility to type 1 diabetes.
Genetic susceptibility to type 1 diabetes (T1D) has been a subject of intensive study for nearly four decades. This article will present the history of these studies, beginning with observations of the Human Leukocyte Antigen (HLA) association in the 1970s, through the advent of DNA-based genotyping methodologies, through recent large, international collaborations and genome-wide association studies. Read more.

Dennis Selkoe outlines research efforts on Alzheimer disease.
Few diagnoses in modern medicine evoke greater apprehension and sadness than Alzheimer disease. Virtually unknown to the public just a generation ago, this protean disorder is now the subject of enormous concern on a personal level and represents a looming catastrophe for society. Most people in developed nations have encountered victims of the disease, often within their own families, and there is a palpable sense of urgency that something be done. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more.

 
 
 

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The Synapse
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Type-1 Diabetes
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Parkinson's Disease
List priceHardcover: $135
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Discounts apply to direct purchases by individual customers only.
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RNA: Life's Indispensable Molecule cover imageRNA: Life's Indispensable Molecule named one of Choice's “Outstanding Academic Titles”

Choice subject editors recognize the most significant titles reviewed during each calendar year by compiling their “Outstanding Academic Titles” list, which is published each January. This year the editors collaborated in choosing from among the 2011 list their favorites for the “Top 25 Books”, and we are pleased and proud to announce that James Darnell’s book, RNA: Life's Indispensable Molecule, has been included on this prestigious list.

More praise for Dr. Darnell’s book:

“RNA: Life's Indispensable Molecule allows undergraduates and graduate students alike to envision, grasp, appreciate and spark fascination of the historical evolution of the importance of RNA in the context of cellular and developmental biology. After reading this book, I have restructured my course for Harvard undergraduates and it's now the only required reading outside primary literature.” —John Rinn, Harvard University

“Jim Darnell’s career in science covers the 60 or so years following the publication of the Watson-Crick structure of DNA. This remarkable book tells a story that parallels his career, dealing at the beginning with the prehistory of research on RNA, DNA, and proteins and then shifting into high gear with a detailed look at the history of bacterial messenger RNA and the author’s own specialty, the RNA of eukaryotic cells....Darnell is an experienced teacher and author of textbooks. His explanations of complex experiments are superb...” —The FASEB Journal

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Free sample available at the Kindle Store!

 

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Save on The Honest Look and Experimental Heart.

These two exciting novels are now available at a new, reduced price of only $4.99 each!

 

Be sure to review our other Kindle editions:

Sydney Brenner cover image Genes & Signals cover image A Genetic Switch cover image Abraham Lincoln's DNA and Other Adventures in Genetics cover image The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives, Updated and Expanded Edition cover image

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The articles below were specially selected by our journal editors and are freely available to read.

 
 

Cold Spring Harbor Protocols cover image Cold Spring Harbor Protocols

Analysis of Glial Cell Development and Function in Drosophila.
Tobias Stork, Rebecca Bernardos, and Marc R. Freeman
doi: 10.1101/pdb.top067587

Magnetic Trap Construction.
Timothée Lionnet, Jean-François Allemand, Andrey Revyakin, Terence R. Strick, Omar A. Saleh, David Bensimon, and Vincent Croquette
doi: 10.1101/pdb.prot067496

 

Genes & Development cover image Genes & Development

Phactr4 regulates directional migration of Enteric Neural Crest through PP1, integrin signaling and cofilin activity.
Ying Zhang, Tae-Hee Kim, and Lee Niswander
Vol. 26 (1) 69-81.

 

Genome Research cover image Genome Research

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
Laura B. Ramsey, Gitte H. Bruun, Wenjian Yang, Lisa R. Treviño, Selina Vattathil, Paul Scheet, Cheng Cheng, Gary L. Rosner, Kathleen M. Giacomini, Yiping Fan, Alex Sparreboom, Torben S. Mikkelsen, Thomas J. Corydon, Ching-Hon Pui11, William E. Evans, and Mary V. Relling
Vol. 22 (1) 1–8.

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We have recently added many new titles to our Sale Shelf. Don’t miss this opportunity to add quality books to your library at price reductions of 50% and more. Quantities are limited, so don’t delay! Here are just a few of those newly reduced:

Landmark Papers in Yeast Biology cover image DNA Replication and Human Disease cover image Davenport’s Dream cover image

Clocks and Rhythms cover image  From a to alpha: cover image Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual cover image 

(Sale Shelf discounts apply to direct purchases by individual US and Canada customers only. Please note that all sales are final.)

 

Rare gene variants critical for personalized drug treatment in cancer and autoimmune diseases

Genome Research published an article describing how rare variants in the SLCO1B1 gene significantly influence response to a drug used to treat cancer and autoimmune disease. GenomeWeb Daily News reported on this study, detailing how this work suggests that future studies may require analysis beyond genotyping for common variants to avoid missing individuals with less-common mutations that will be important for treatment response.

 

Leraning & Memory cover image Learning & Memory

Working memory, long-term memory, and medial temporal lobe function.
Annette Jeneson and Larry R. Squire
Vol. 19 (1) 15–25.

 

RNA cover image RNA

Production of artificial piRNAs in flies and mice.
Felix Muerdter, Ivan Olovnikov, Antoine Molaro, Nikolay V. Rozhkov, Benjamin Czech, Assaf Gordon, Gregory J. Hannon, and Alexei A. Aravin
Vol. 18 (1) 42-52.

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CSH Perspectives cover imageA new type of online review journal

• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field

Read these essential papers in this month’s issue:

The matrisome: Richard Hynes catalogs ECM constituents.
Completion of genome sequences for many organisms allows a reasonably complete definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core matrisome” comprises ∼300 proteins. In addition there are large numbers of ECM-modifying enzymes, ECM-binding growth factors, and other ECM-associated proteins. Read more.

Steven Benner discusses strategies for studying RNA’s role in the origin of life.
No community-accepted scientific methods are available today to guide studies on what role RNA played in the origin and early evolution of life on Earth. Further, a definition-theory for life is needed to develop hypotheses relating to the “RNA First” model for the origin of life. Read more.

Synaptic vesicle exocytosis: Thomas Südhof reviews how neurotransmitters are released at the synaptic cleft.
Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for “soluble NSF-attachment protein receptor”) and SM (for “Sec1/Munc18-like”) proteins. Read more.

Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives

Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here.

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HISTORIC MOMENTS IN
MOLECULAR BIOLOGY

 

CSH Symposium, Vol. XVIII, 1953 photo

Viruses
(CSH Symposium, Vol. XVIII, 1953)

It was with the 1953 meeting that the "golden age" of Cold Spring Harbor Symposium began. It was this meeting that established the Cold Spring Harbor Symposia as the places to be to hear the latest in the new field of molecular genetics. The Symposia volumes for these genetics meetings served as primary sources of data in the years when Nature and Science were the only journals publishing in this area. And of this set of meetings—from 1953 to 1966—it is the 1953 Symposium that has taken on a mythic quality. Read more.

Hundreds of important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia. These meetings, held each year on the tranquil grounds of one of the world's leading research institutes, have been notable events in biomedical research since 1933.  Now this essential archive, dating from 1933 to 2003, is available online. Among highly influential volumes is the 1953 meeting “Viruses” (Vol. XVIII), above is an excerpt from the exclusive new online introduction to this volume. Read more.

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HIV: From Biology to Prevention and Treatment cover image  Molecular Cloning, 3rd Edition cover image  RNA: A Laboratory Manual cover image

Statistics at the Bench cover image  The Biology of Alzheimer Disease cover image  Imaging: A Laboratory Manual cover image

 

HIV: From Biology to Prevention and Treatment

Molecular Cloning: A Laboratory Manual (Third Edition)

RNA: A Laboratory Manual

Statistics at the Bench

The Biology of Alzheimer Disease

Imaging: A Laboratory Manual

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A Fascinating Adventure in Biomedical Research

Alzheimer disease insidiously attacks the brain and deprives people of their most human qualities, leading to memory loss, behavior changes, and ultimately, death. An essay in this month’s issue of Cold Spring Harbor Perspectives in Medicine provides an excellent overview of modern Alzheimer research, its origins and development, scope, driving forces, and key questions, as well as competing ideas and findings within the field. It was written by Dennis Selkoe, Eckhard Mandelkow, and David Holtzman, editors of our recent book The Biology of Alzheimer Disease.

In the essay, Selkoe and colleagues outline key developments that followed the first description of the disease by Alois Alzheimer in 1907. They explain how the discoveries of tau and amyloid β-protein precursor in the late 1980s and early 1990s brought Alzheimer research into sync with basic research in molecular genetics and protein chemistry. Furthermore, the recognition of Alzheimer disease as a common disorder — currently estimated to affect 20-25 million people worldwide — has helped define it as an urgent problem in biomedical research.

But beyond that, Selkoe and colleagues describe how tackling a complicated disease — and one that affects the most human qualities of memory, reasoning, language, and emotion — can be intellectually rewarding. “The complexity of the problem and the diverse ways in which one might think about approaching it make for a fascinating adventure in biomedical research,” they write.

For more on Alzheimer research — including discussion of competing ideas between “BAPtists” and “TAUists” — read the complete essay here.

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Cold Spring Harbor Laboratory is a private, nonprofit institution for research and education in the biological sciences. The Lab is internationally recognized for its excellence in research in cancer, neurobiology, plant genetics, and bioinformatics, and offers a broad range of educational programs for professional scientists and scientists-in-training, from elementary school students to Nobel laureates. Check the job listings below for opportunities to become a part of this important institution. Here are a few that are currently listed:

  • Senior Web Designer
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  • Educator, Middle School
  • Course Aide
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Check out the latest job opportunities at Cold Spring Harbor Laboratory HERE.

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