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In This Issue January 2012
New and Forthcoming Titles
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The Kindle version of this must-have resource for molecular biologists is now available in electronic format (via Kindle app) for your iPad, iPhone, Android, Windows PC, Mac, Windows Phone 7, Blackberry, or Kindle device! Imaging: A Laboratory Manual is the cornerstone of our new laboratory manual series on imaging techniques, which have become tremendously valuable in nearly every field of biological research. This volume is designed as a general reference and describes the theory and practice of a wide array of imaging methods, but becomes an even more effective research tool in an electronic format. Visit the Kindle Store and download the free sample material to see for yourself how this manual comes to life with live links and beautiful full-color illustrations.
HIV: From Biology to Prevention and Treatment This book provides a comprehensive review of HIV research, covering everything from the pathogenesis of HIV infection to prevention. Contributors explore the origins and evolution of HIV, the HIV replication cycle, host–virus interactions, host immune responses, and HIV transmission. Vaccines, cell and gene therapies, antiretroviral drugs, microbicides, and behavioral strategies for the treatment and prevention of HIV infections are also explored. HIV research tops Science’s list of advances in 2011! A clinical trial, HPTN 052, finds that antiretroviral drugs can be used to dramatically lower the risk of transmitting HIV. HIV: From Biology to Prevention and Treatment, is a timely and valuable review of HIV research, and includes a complete section on Therapy and Prevention.
The Biology of Alzheimer Disease This comprehensive volume includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Experts in the field discuss the biochemistry and cell biology of amyloid β-protein precursor (APP), tau, presenilin, β-secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis.
Angiogenesis: Biology and Pathology This volume reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered. |
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Support
Research and Did you know that buying directly from CSHL Press enables you to save money on any title we publish? As a member of our Discount Program, you will enjoy prices that are frequently lower than those of any other online site – including Amazon. Regardless of where you make your purchase, all revenue from sales of CSHL Press publications supports research at Cold Spring Harbor Laboratory. However, when you buy directly from our website, you provide a greater level of assistance. As a member of our Discount Program, you will also be the first to hear about new titles arriving in our warehouse and will receive exclusive special offers. For complete details, click here. |
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Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect. Read these essential papers in this month’s issue: A vaccine for AIDS: Gary Nabel on developing immunogens that generate broadly neutralizing antibodies to HIV-1. The genetics of diabetes: Janelle Noble and Henry Erlich review the loci associated with susceptibility to type 1 diabetes. Dennis Selkoe outlines research efforts on Alzheimer disease. Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives Visit here for this month’s complete table of contents and to learn more. |
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We are offering special pre-publication pricing on three upcoming titles:
Discounts apply to direct purchases by individual customers only. |
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 RNA: Life's Indispensable Molecule named one of Choice's “Outstanding Academic Titles”
Choice subject editors recognize the most significant titles reviewed during each calendar year by compiling their “Outstanding Academic Titles” list, which is published each January. This year the editors collaborated in choosing from among the 2011 list their favorites for the “Top 25 Books”, and we are pleased and proud to announce that James Darnell’s book, RNA: Life's Indispensable Molecule, has been included on this prestigious list. More praise for Dr. Darnell’s book: “RNA: Life's Indispensable Molecule allows undergraduates and graduate students alike to envision, grasp, appreciate and spark fascination of the historical evolution of the importance of RNA in the context of cellular and developmental biology. After reading this book, I have restructured my course for Harvard undergraduates and it's now the only required reading outside primary literature.” —John Rinn, Harvard University “Jim Darnell’s career in science covers the 60 or so years following the publication of the Watson-Crick structure of DNA. This remarkable book tells a story that parallels his career, dealing at the beginning with the prehistory of research on RNA, DNA, and proteins and then shifting into high gear with a detailed look at the history of bacterial messenger RNA and the author’s own specialty, the RNA of eukaryotic cells....Darnell is an experienced teacher and author of textbooks. His explanations of complex experiments are superb...” —The FASEB Journal |
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Free sample available at the Kindle Store!
Save on The Honest Look and Experimental Heart. These two exciting novels are now available at a new, reduced price of only $4.99 each!
Be sure to review our other Kindle editions:
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The articles below were specially selected by our journal editors and are freely available to read. |
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Analysis of Glial Cell Development and Function in Drosophila.
Phactr4 regulates directional migration of Enteric Neural Crest through PP1, integrin signaling and cofilin activity.
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. |
We have recently added many new titles to our Sale Shelf. Don’t miss this opportunity to add quality books to your library at price reductions of 50% and more. Quantities are limited, so don’t delay! Here are just a few of those newly reduced:
(Sale Shelf discounts apply to direct purchases by individual US and Canada customers only. Please note that all sales are final.) |
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Rare gene variants critical for personalized drug treatment in cancer and autoimmune diseases Genome Research published an article describing how rare variants in the SLCO1B1 gene significantly influence response to a drug used to treat cancer and autoimmune disease. GenomeWeb Daily News reported on this study, detailing how this work suggests that future studies may require analysis beyond genotyping for common variants to avoid missing individuals with less-common mutations that will be important for treatment response.
Working memory, long-term memory, and medial temporal lobe function.
Production of artificial piRNAs in flies and mice. |
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• Spanning the complete spectrum of the molecular life sciences Read these essential papers in this month’s issue: The matrisome: Richard Hynes catalogs ECM constituents. Steven Benner discusses strategies for studying RNA’s role in the origin of life. Synaptic vesicle exocytosis: Thomas Südhof reviews how neurotransmitters are released at the synaptic cleft. Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here. |
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HISTORIC MOMENTS IN
 Viruses It was with the 1953 meeting that the "golden age" of Cold Spring Harbor Symposium began. It was this meeting that established the Cold Spring Harbor Symposia as the places to be to hear the latest in the new field of molecular genetics. The Symposia volumes for these genetics meetings served as primary sources of data in the years when Nature and Science were the only journals publishing in this area. And of this set of meetings—from 1953 to 1966—it is the 1953 Symposium that has taken on a mythic quality. Read more. |
HIV: From Biology to Prevention and Treatment Molecular Cloning: A Laboratory Manual (Third Edition) |
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A Fascinating Adventure in Biomedical Research Alzheimer disease insidiously attacks the brain and deprives people of their most human qualities, leading to memory loss, behavior changes, and ultimately, death. An essay in this month’s issue of Cold Spring Harbor Perspectives in Medicine provides an excellent overview of modern Alzheimer research, its origins and development, scope, driving forces, and key questions, as well as competing ideas and findings within the field. It was written by Dennis Selkoe, Eckhard Mandelkow, and David Holtzman, editors of our recent book The Biology of Alzheimer Disease. |
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Cold Spring Harbor Laboratory is a private, nonprofit institution for research and education in the biological sciences. The Lab is internationally recognized for its excellence in research in cancer, neurobiology, plant genetics, and bioinformatics, and offers a broad range of educational programs for professional scientists and scientists-in-training, from elementary school students to Nobel laureates. Check the job listings below for opportunities to become a part of this important institution. Here are a few that are currently listed:
Check out the latest job opportunities at Cold Spring Harbor Laboratory HERE. |
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2012 CSHL Meetings & Conferences |
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Cold Spring Harbor Laboratory's DNA Learning Center (DNALC) is the world’s first science center devoted entirely to genetics education.
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For questions regarding journal subscriptions and site licensing, please contact: Kathy Cirone |
For all other inquiries, please contact: Geraldine Jaitin |
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