The Autophagy-Cancer Connection
03/11/2009
In an upcoming G&D paper, Dr. Masashi Narita (Cancer Research UK) and colleagues functionally link autophagy and cellular senescence. Using a model of oncogenic ras-induced senescence, the authors show that senescence activates autophagy in human fibroblast cells. Dr. Narita and colleagues demonstrate that over-expression of an autophagy inducer also induces senescence, while the inhibition of autophagy delays senescence. Future work will be aimed at delineating the precise role of autophagy in tumorigenesis, but this paper firmly establishes a key role for autophagy in senescence. Refers to: Autophagy mediates the mitotic-senescence transition
Andrew R. J. Young, Masako Narita, Manuela Ferreira, Kristina Kirschner, Mahito Sadaie, Jeremy F.J. Darot, Simon Tavare, Satoko Arakawa, Shigeomi Shimizu, Fiona M Watt, and Masashi Narita #### Genes & Development is a publication of the Cold Spring Harbor Laboratory Press. The Cold Spring Harbor Laboratory is a private, non-profit, basic research and educational institution. Scientists at the Laboratory conduct groundbreaking research in cancer, neurobiology, plant molecular genetics, genomics and bioinformatics. The Laboratory is recognized internationally for its educational activities, which include an extensive program of scientific meetings and courses that attract more than 8000 scientists to the campus each year. For more information about the Cold Spring Harbor Laboratory, visit http://www.cshl.edu or call the Department of Public Affairs at (516) 367-8455. Contact:
Heather Cosel-Pieper
Genes & Development
Cold Spring Harbor Laboratory
tel. (516) 422-4018
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