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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2017 • ISSN 0890-9369; Volume 31 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2017, 24 semimonthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetical Society of Great Britain.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2017 • ISSN: 1088-9051; Volume 27 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2017, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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RNA [Journal]
 
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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2017 • ISSN 1549-5485; Volume 24; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2017, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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Genes & Development [Journal]
Genome Research [Journal]
RNA [Journal]
 
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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2017 • ISSN: 2157-1422; Volume 7 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2017, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine. 

Cold Spring Harbor Perspectives in Medicine is freely available until 2013.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2017 • ISSN: 1943-0264; Volume 9 includes full online access
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cironek@cshl.edu.

January - December 2017, 12 monthly issues
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A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the ‘bible’ of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal’s Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. “There are many review articles published each year, but they’re usually on one particular aspect of one particular field,” he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer’s to plant biology."

CSH Perspectives articles are all commissioned as ‘collections’ by a board of eminent academic editors and gradually accumulate online at the journal’s website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library’s HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2017 • ISSN: 1559-6095; Volume 12; includes full online access
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January - December 2017, 12 monthly issues
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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor’s renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559–6095 / online, monthly

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  • Antibodies
  • Bioinformatics / Genomics
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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2017 • ISSN 1355-8382; Volume 23; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2017, 12 monthly issues
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Description

RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Synthetic Biology: Tools for Engineering Biological Systems


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyGenomicsMolecular BiologyGenetics

Edited by Daniel G. Gibson, J. Craig Venter Institute; Clyde A. Hutchison III, J. Craig Venter Institute; Hamilton O. Smith, J. Craig Venter Institute; J. Craig Venter, J. Craig Venter Institute

Download a Free Excerpt from Synthetic Biology: Tools for Engineering Biological Systems:

Preface
Minimal Cells—Real and Imagined
Index


© 2017 • 280 pages, illustrated (55 color, 9 B&W), index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-18-2
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Description

Synthetic biology involves the rational design and construction of biological components and systems—from genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR–Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered.

The authors also explore ways to produce new organisms and products that have particular attributes—for example, microbial “molecular factories,” synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

Contents

Preface
DESIGN, SYNTHESIS, AND MANIPULATION OF GENOMES
Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology
Randall A. Hughes and Andrew D. Ellington
Minimal Cells–Real and Imagined
John I. Glass, Chuck Merryman, Kim S. Wise, Clyde A. Hutchison III, and Hamilton O. Smith
Genome-Editing Technologies: Principles and Applications
Thomas Gaj, Shannon J. Sirk, Sai-lan Shui, and Jia Liu
MODIFYING THE CENTRAL DOGMA
Alternative Watson–Crick Synthetic Genetic Systems
Steven A. Benner, Nilesh B. Karalkar, Shuichi Hoshika, Roberto Laos, Ryan W. Shaw, Mariko Matsuura, Diego Fajardo, and Patricia Moussatche
At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code
Han Xiao and Peter G. Schultz
EXPERIMENTAL AND COMPUTATIONAL APPROACHES TO THE DESIGN AND IMPROVEMENT OF BIOLOGICAL PROCESSES
Cell-Free Synthetic Biology: Engineering Beyond the Cell
Jessica G. Perez, Jessica C. Stark, and Michael C. Jewett
Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities
Jessica K. Polka, Stephanie G. Hays, and Pamela A. Silver
Design Automation in Synthetic Biology
Evan Appleton, Curtis Madsen, Nicholas Roehner, and Douglas Densmore
APPLICATIONS TO SMALL MOLECULE PRODUCTION
The Need for Integrated Approaches in Metabolic Engineering
Anna Lechner, Elizabeth Brunk, and Jay D. Keasling
Synthetic Biology of Natural Products
Rainer Breitling and Eriko Takano
APPLICATIONS TO HIGHER ORGANISMS
Engineering Gene Circuits for Mammalian Cell–Based Applications
Simon Ausländer and Martin Fussenegger
Synthetic Biology in Cell and Organ Transplantation
Sean Stevens
Synthetic Morphogenesis
Brian P. Teague, Patrick Guye, and Ron Weiss
Synthetic Botany
Christian R. Boehm, Bernardo Pollak, Nuri Purswani, Nicola Patron, and Jim Haseloff
Phage Therapy in the Era of Synthetic Biology
E. Magda Barbu, Kyle C. Cady, and Bolyn Hubby
Index
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Synthetic Biology: Tools for Engineering Biological Systems

Synthetic biology involves the rational design and construction of biological components and systems—from genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR–Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered.

The authors also explore ways to produce new organisms and products that have particular attributes—for example, microbial “molecular factories,” synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

Download a Free Excerpt from Synthetic Biology: Tools for Engineering Biological Systems:

Preface
Minimal Cells—Real and Imagined
Index

More INFO Below
Description
Contents
   

© 2017 • 280 pages, illustrated (55 color, 9 B&W), index
Hardcover • $122.85 • ISBN 978-1-621821-18-2


 

Description

Synthetic biology involves the rational design and construction of biological components and systems—from genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR–Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered.

The authors also explore ways to produce new organisms and products that have particular attributes—for example, microbial “molecular factories,” synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

 
Add To Cart  Add this Title to Order List 
 

Contents

Preface
DESIGN, SYNTHESIS, AND MANIPULATION OF GENOMES
Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology
Randall A. Hughes and Andrew D. Ellington
Minimal Cells–Real and Imagined
John I. Glass, Chuck Merryman, Kim S. Wise, Clyde A. Hutchison III, and Hamilton O. Smith
Genome-Editing Technologies: Principles and Applications
Thomas Gaj, Shannon J. Sirk, Sai-lan Shui, and Jia Liu
MODIFYING THE CENTRAL DOGMA
Alternative Watson–Crick Synthetic Genetic Systems
Steven A. Benner, Nilesh B. Karalkar, Shuichi Hoshika, Roberto Laos, Ryan W. Shaw, Mariko Matsuura, Diego Fajardo, and Patricia Moussatche
At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code
Han Xiao and Peter G. Schultz
EXPERIMENTAL AND COMPUTATIONAL APPROACHES TO THE DESIGN AND IMPROVEMENT OF BIOLOGICAL PROCESSES
Cell-Free Synthetic Biology: Engineering Beyond the Cell
Jessica G. Perez, Jessica C. Stark, and Michael C. Jewett
Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities
Jessica K. Polka, Stephanie G. Hays, and Pamela A. Silver
Design Automation in Synthetic Biology
Evan Appleton, Curtis Madsen, Nicholas Roehner, and Douglas Densmore
APPLICATIONS TO SMALL MOLECULE PRODUCTION
The Need for Integrated Approaches in Metabolic Engineering
Anna Lechner, Elizabeth Brunk, and Jay D. Keasling
Synthetic Biology of Natural Products
Rainer Breitling and Eriko Takano
APPLICATIONS TO HIGHER ORGANISMS
Engineering Gene Circuits for Mammalian Cell–Based Applications
Simon Ausländer and Martin Fussenegger
Synthetic Biology in Cell and Organ Transplantation
Sean Stevens
Synthetic Morphogenesis
Brian P. Teague, Patrick Guye, and Ron Weiss
Synthetic Botany
Christian R. Boehm, Bernardo Pollak, Nuri Purswani, Nicola Patron, and Jim Haseloff
Phage Therapy in the Era of Synthetic Biology
E. Magda Barbu, Kyle C. Cady, and Bolyn Hubby
Index
 

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Prion Biology


Subject Area(s):  Cell BiologyProteins and ProteomicsHuman Biology and Disease

Edited by Stanley B. Prusiner, University of California, San Francisco

Due August 2017 • 350 pages (approx.), illustrated, index
Paperback • $79 (click here to price in UK Pounds)
ISBN  978-1-621822-84-4

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Description

Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson’s. But some recently discovered prion-like proteins do not appear to induce pathological changes and, in fact, may be key players in basic biological processes such as transcription, immune regulation, and memory formation.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the expanding roles of prions and prion-like proteins in health and disease. The contributors review the structures of prions and prion-like proteins, how they aggregate into amyloid fibrils and other insoluble complexes, and the unique biological properties of the aggregated forms (e.g., infectivity, gain/loss of function, and self-templating). The normal physiological roles of prion-like proteins (e.g., CPEB in the brain and MAVS in the immune response) are discussed, as is the formation of abnormal protein aggregates via prion-like mechanisms in various human diseases.

The authors also discuss prions in yeast and other fungi, which are convenient models for studying mechanisms of amyloid formation and propagation. This volume is therefore an essential reference for biochemists, cell and molecular biologists, and all who wish to understand how these alternatively folded, self-propagating proteins function.

Contents

(preliminary)
Widening Spectrum of Prion Biology and Diseases
Stanley B. Prusiner
Experimental Approaches to Neurodegeneration
Stanley B. Prusiner and Joel Watts
The HET-S/s Prion Motif in the Control of Programmed Cell Death
Roland Riek and Sven J. Saupe
The Amyloid Phenomenon and its Links with Human Disease
Christopher M. Dobson
Protein Quality Control in Health and Disease
Tatyana Dubnikov, Tziona Ben-Gedalya, and Ehud Cohen
Yeast and Fungal Prions
Reed B. Wickner
Prions, Chaperones, and Proteostasis in Yeast
Tatiana A. Chernova, Keith D. Wilkinson, and Yury O. Chernoff
The 3D Structures of Amyloids
Roland Riek
Functional Prions in the Brain
Joseph B. Rayman and Eric R. Kandel
Prion-Like Polymerization in Immunity and Inflammation
Xin Cai, Hui Xu, and Zhijian J. Chen
Cross-β Polymerization of Low Complexity Sequence Domains
Masato Kato and Steven L. McKnight
Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?
Danielly C.F. Costa, Guilherme A.P. de Oliveira, Elio A. Cino, Iaci N. Soares, Luciana P. Rangel, and Jerson L. Silva
Molecular Genetics of Neurodegenerative Dementias
Flora I. Hinz and Daniel H. Geschwind
Tau PET Imaging
Hartmuth C. Kolb and José Ignacio Andrés
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer’s and Parkinson’s Diseases
Heiko Braak and Kelly Del Tredici
Inactivation of Prions—Deep Brain Stimulation and Synuclein Prions
Kurt Giles and Stanley B. Prusiner
Index
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