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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2021 • ISSN 0890-9369; Volume 35 includes full online access
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January - December 2021, 24 monthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetics Society.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2021 • ISSN: 1088-9051; Volume 31 includes full online access
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January - December 2021, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2021 • ISSN 1549-5485; Volume 28; includes full online access
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January - December 2021, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2021 • ISSN: 2157-1422; Volume 11 includes full online access
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cironek@cshl.edu.

January - December 2021, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2021 • ISSN: 1943-0264; Volume 13 includes full online access
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cironek@cshl.edu.

January - December 2021, 12 monthly issues
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A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal's website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library's HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2021 • ISSN: 1559-6095; Volume 16; includes full online access
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January - December 2021, 12 monthly issues
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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

Read within Top Institutions and Companies Such as:

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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2021 • ISSN 1355-8382; Volume 27; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2021, 12 monthly issues
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Description

RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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T-Cell Memory


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyImmunology and VaccinesCytology

Edited by David Masopust, University of Minnesota School of Medicine; Rafi Ahmed, Emory University School of Medicine

Due July 2021 • 400 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621821-55-7
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  •     Description    
  •     Contents    

Description

T cells are a major component of adaptive immunity, differentiating to form distinct subsets that directly attack pathogens, promote the activity of antibody-producing cells, and regulate other components of the immune system. This volume discusses the roles of these different subsets and how they are generated.

Contents

Preliminary
Topic I. Memory T-cell heterogeneity and classification: How should we name our T-cells?
Memory T-Cell Heterogeneity and Terminology
Yuki Muroyama and E. John Wherry
The Naming of Memory T-Cell Subsets
Stephen C. Jameson
How to Reliably Define Human CD8+ T-Cell Subsets: Markers Playing Tricks
Michiel C. van Aalderen, Rene A.W. van Lier, and Pleun Hombrink
Formation of Tissue-Resident CD8+ T-Cell Memory
Feline E. Dijkgraaf, Lianne Kok, and Ton N.M. Schumacher
CD8+ T Cell Memory: The Why, The When, and The How
Stephen J. Turner Taylah J. Bennett, and Nicole L. La Gruta
Topic II. Memory T-cell differentiation models
A Regenerative Perspective on Successful and Failed T-Cell Immunity
Steven L. Reiner
Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation
Susan M. Kaech, Bryan McDonald, and Yagmur Farsakoglu
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells
Shanel Tsuda and Matthew E. Pipkin
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory
Tasha A. Morrison, William H. Hudson, Danielle A. Chisolm, Yuka Kanno, Han-Yu Shih, Rafi Ahmed, Jorge Henao-Mejia, Markus Hafner, and John J. O’Shea
Temporal and Epigenetic Control of Plasticity and Fate Decision During CD8+ T-Cell Memory Differentiation
Luigia Pace
Metabolic Control of Memory T-Cell Generation and Stemness
Jana L. Raynor, Nicole M. Chapman, and Hongbo Chi
A Single-Cell Perspective on Memory T-Cell Differentiation
Lorenz Kretschmer, Dirk H. Busch, and Veit R. Buchholz
Topic III. Tissue memory
T-Cell Memory: Tissue Memory
Simone L. Park and Laura K. Mackay
Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification
Shiki Takamura
Influenza-Specific Lung-Resident Memory CD8+ T Cells
Stephanie van de Wall, Vladimer P. Badovinac, and John T. Harty
Long-Lived Skin Resident Memory T-Cells Contribute to Concomitant Immunity in Cutaneous Leishmaniasis
Phillip Scott
Area Under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets
Loreto Parga-Vidal and Klaas P.J.M. van Gisbergen
Topic IV. Memory T-cell homeostasis and durability
CD4+ Memory T-Cell Formation During Acute Infections
Peter Krueger, Kevin Osum, and Marc K. Jenkins
Defining the Molecular Hallmarks of T-Cell Memory
Caitlin Zebley, Rama Akondy, Benjamin Youngblood, and Haydn Kissick
Homeostasis of Naïve and Memory T Lymphocytes
Takeshi Kawabe, Jaeu Yi, and Jonathan Sprent
Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory
Andreas Radbruch, Mairi Anne McGrath, Francesco Siracusa, Ute Hoffmann, Özen Sercan-Alp, Andreas Hutloff, Koji Tokoyoda, Hyun-Dong Chang, and Jun Dong
Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates
Susan L. Swain, Michael C. Jones, Priyadharshini Devarajan, Jingya Xia, Richard W. Dutton, Tara M. Strutt, and K. Kai McKinstry
Index

   

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Combining Human Genetics and Causal Inference to Understand Human Disease and Development


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseGeneticsDiseases

Edited by George Davey Smith, University of Bristol; Rebecca Richmond, University of Bristol; John-Baptiste Pingault, University College London

Due July 2021 • 225 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-81-0
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  •     Contents    

Description

Mendelian randomization and related techniques allow researchers to use knowledge about genetic factors that contribute to a disease to predict whether other risk factors, such as environmental exposure, play a part. This volume examines how these approaches allow researchers to make causal inferences about modifiable exposures and how this can benefit public health.

Contents

Preliminary
1. New Opportunities
George Davey Smith, Rebecca Richmond, and John-Baptiste Pingault
Concepts
2. The Meaning of “Cause” in Genetics
Kate E. Lynch
Family based study designs
3. Twins and Causal Inference: Leveraging Nature’s Experiment
Tom A. McAdams, Fruhling V. Rijsdijk, Helena M.S. Zavos, and Jean-Baptiste Pingault
4. Family-Based Designs that Disentangle Inherited Factors from Pre- and Post-Natal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal Versus Paternal Comparisons and Adoption Designs
Anita Thapar and Frances Rice
Population-based genetic designs
5. Mendelian Randomization: Concepts and Scope
Rebecca C. Richmond and George Smith Davey
6. Polygenic Mendelian Randomization
Frank Dudbridge
7. Multivariable Mendelian Randomization and Mediation
Eleanor Sanderson
INTEGRATION OF METHODS AND DATA
8. Integrating Family-Based and Mendelian Randomization Designs
Liang-Dar Hwang, Neil M. Davies, Nicole M. Warrington, and David M. Evans
9. Causal Inference Methods to Integrate Omics and Complex Traits
Eleonora Porcu, Jennifer Sjaarda, Kaido Lepik, Cristian Carmeli, Liza Darrous, Jonathan Sulc, Ninon Mounier, and Zoltán Kutalik
10. Computational Tools for Causal Inference in Genetics
Tom G. Richardson, Jie Zheng, and Tom R. Gaunt
Genetics and causation in practice
11. Using Mendelian Randomization to Improve the Design of Randomized Trials
Brian A. Ference, Michael V. Holmes, and George Davey Smith
12. Triangulating Evidence Through the Inclusion of Genetically Informed Designs
Marcus R. Munafò, Julian P.T. Higgins, and George Davey Smith
Index

   

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Auxin Signaling: From Synthesis to Systems Biology, Second Edition


Subject Area(s):  Cell BiologyBiochemistryPlant Biology

Edited by Dolf Weijers, Wageningen University, The Netherlands; Karin Ljung, Umeå Plant Science Centre, Umea, Sweden; Mark Estelle, University of California, San Diego; Ottoline Leyser, University of Cambridge

Due July 2021 • 350 pages (approx.), illustrated, index
Hardcover • $135
ISBN  978-1-621824-00-8

  •     Description    
  •     Contents    

Description

Auxin is an important plant hormone that controls numerous aspects of development and physiology, including responses to light, tissue patterning, and organogenesis. The book examines how auxin is synthesized, the biochemical basis for its actions, and its various different roles in plant biology.

Contents

Preliminary
The Nature of Auxin as a Signaling Molecule
Jiri Friml
Auxin Metabolism in Plants
Rubén Casanova-Sáez, Eduardo Mateo-Bonmatí, and Karin Ljung
Transport
Claus Schwechheimer, Ulrich Hammes, and Angus Murphy
Structural Aspects of Auxin Signaling
Nicholas Morffy and Lucia C. Strader
No Time for Transcription—Rapid Auxin Responses in Plants
Shiv Mani Dubey, Nelson Bernard Calixte Serre, Denisa Oulehlová, Pruthvi Vittal, and Matyáš Fendrych
The Story of Auxin Binding Protein 1 (ABP1)
Richard Napier
Noncanonical Auxin Signaling
Heather Marie McLaughlin, Aaron Chun Hou Ang, and Lars Østergaard
Auxin in the Shoot Meristem
Teva Vernoux and Markéta Pernisová
Auxin in Root Development
Stefan Kepinski
Auxin-Regulated Lateral Root Organogenesis
Nicola Cavallari, Christina Artner, and Eva Benkova
Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System
Dhruv Lavania , Nguyen Manh Linh, and Enrico Scarpella
An Essential Function for Auxin in Embryo Development
Subodh Verma, Venkata Pardha Saradhi Attuluri, and Hélène S. Robert
Auxin and Flower Development: A Blossoming Field
Mara Cucinotta, Alex Cavalleri, John William Chandler, and Lucia Colombo
Regulation of Pavement Cell Shape
Siobhan Braybrook
Auxin Interactions with Other Hormones in Plant Development
Serina M. Mazzoni-Putman, Javier Brumos, Chengsong Zhao, Jose M. Alonso, and Anna N. Stepanova
Gene Regulatory Networks
Jan Lohmann
Abiotic Stress Networks
Ute Voss and Malcolm Bennett
Auxin in Pathogen Response
Barbara Kunkel
Auxin-Environment Integration in Growth Responses to Forage for Resources
Jorge J. Casal and José M. Estevez
On the Evolutionary Origins of Land Plant Auxin Biology
John L. Bowman, Eduardo Flores Sandoval, and Hirotaka Kato
Auxin Biology in Bryophyta: A Simple Platform With Versatile Functions
Hidemasa Suzuki, Takayuki Kohchi, and Ryuichi Nishihama
Auxin in Monocots
Paula McSteen
The Systems and Synthetic Biology of Auxin
Clay Wright, Britney L. Moss, and Jennifer L. Nemhauser
Modeling Auxin Signaling in Roots: Auxin Computations
Jaap Rutten, Thea van den Berg, Kirsten ten Tusscher
Computational Models of Auxin-Driven Patterning in Shoots
Mikolaj Cieslak, Andrew Owens, and Przemyslaw Prusinkiewicz
Chemical Biology in Auxin Research
Ken-ichiro Hayashi
Index
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