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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2018 • ISSN 0890-9369; Volume 32 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 24 semimonthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetical Society of Great Britain.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2018 • ISSN: 1088-9051; Volume 28 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2018 • ISSN 1549-5485; Volume 245; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 20187, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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Genome Research [Journal]
RNA [Journal]
 
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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 2157-1422; Volume 8 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 1943-0264; Volume 10 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
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A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal�s website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library�s HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 1559-6095; Volume 13; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

Read within Top Institutions and Companies Such as:

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INIST-CNRS Bibliovie
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  • High Throughput Analysis
  • Imaging / Microscopy
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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2018 • ISSN 1355-8382; Volume 24; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2018, 12 monthly issues
Journal Subscription

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RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Chromosome Segregation and Structure


Subject Area(s):  Cell BiologyGeneticsCancer Biology

Edited by David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

Due July 2018 • 400 pages (approx.), illustrated, index
Paperback • $129 103.20
ISBN  978-1-621822-87-5
You save: 20%
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This title also available in: Hardcover

  •     Description    
  •     Contents    

Description

The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. The topics covered at the meeting included: Meiosis; Mitosis; Chromosome Segregation; Centrosomes and Centrioles; Ploidy, Chromosome Segregation Errors & Disease; Asymmetric Cell Division; Nuclear Architecture; Chromosome Structure and Condensation; Sister Chromatid Cohesion; Genome Stability; and Germ Cells. Numerous speakers participated in interviews during the course of the Symposium week and transcripts of those discussions and the Dorcas Cummings lecture by David Page are included.

Contents

Symposium Participants
Foreword
Chromatin, Histones, And Instability

Shaping Chromatin in the Nucleus: The Bricks and the Architects
David Sitbon, Katrina Podsypanina, Tejas Yadav, and Genevieve Almouzni

On the Importance of Satellite Sequence Repression for Genome Stability
Peter Zeller and Susan M. Gasser

Structure and Epigenetic Regulation of Chromatin Fibers
Ping Chen and Guohong Li

Chromosome Biology and Genome Architecture

The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure
Sarah C. Hsu and Gerd A. Blobel

Emerging Evidence of Chromosome Folding by Loop Extrusion
Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, and Leonid A. Mirny

SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches
Prabhakar R. Gudla, Koh Nakayama, Gianluca Pegoraro, and Tom Misteli

Centromeres and Kinetochores

Remarkable Evolutionary Plasticity of Centromeric Chromatin
Steven Henikoff, Jitendra Thakur, Sivakanthan Kasinathan, and Paul B. Talbert

Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation
Simon Jenni, Yoana N. Dimitrova, Roberto Valverde, Stephen M. Hinshaw, and Stephen C. Harrison

Aurora A Kinase Function at Kinetochores
Jennifer DeLuca

RotoStep: A Chromosome Dynamics Simulator Reveals Mechanisms of Loop Extrusion
Josh Lawrimore, Brandon Friedman, Ayush Doshi, and Kerry Bloom

Taming the Beast: Control of APC/CCdc20-Dependent Destruction
Pablo Lara-Gonzalez, Taekyung Kim, and Arshad Desai

Organizing Chromosomes during Segregation

Noncanonical Biogenesis of Centrioles and Basal Bodies
Catarina Nabais, Sónia Gomes Pereira, and Mónica Bettencourt-Dias

Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer
Erich A. Nigg, Dominik Schnerch, and Olivier Ganier

The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules
Jennifer T. Wang and Tim Stearns

Mitotic Chromosome Assembly In Vitro: Functional Cross Talk between Nucleosomes and Condensins
Keishi Shintomi and Tatsuya Hirano

Mitosis and Cell Cycle

Spindle-to-Cortex Communication in Cleaving Frog Eggs
Timothy J. Mitchison and Christine M. Field

Nucleosome-Dependent Pathways That Control Mitotic Progression
Hironori Funabiki, Christopher Jenness, and Christian Zierhut

Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
Kata Sarlós, Andreas Biebricher, Erwin J.G. Petermann, Gijs J.L. Wuite, and Ian D. Hickson

Low-Level, Global Transcription during Mitosis and Dynamic Gene Reactivation during Mitotic Exit
Katherine C. Palozola, Hong Liu, Dario Nicetto, and Kenneth S. Zaret

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates
Stephen C. West and Ying Wai Chan

Meiosis

Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals
So I. Nagaoka and Mitinori Saitou

Regulation of Crossover Frequency and Distribution during Meiotic Recombination
Takamune T. Saito and Monica P. Colaiácovo

Emerging Roles of the Ubiquitin-Proteasome System in the Regulation of Meiotic Recombination
Neil Hunter

Cellular and Molecular Mechanisms of Centromere Drive
Michael A. Lampson and Ben E. Black

Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I
Seira Miyazaki, Jihye Kim, Takeshi Sakuno, and Yoshinori Watanabe

Germ Cells, Imprinting, Gene Dosage, and Regulation

Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease and Evolution
Rafael Galupa and Edith Heard

Dynamic Control of Chromosome Topology and Gene Expression by a Chromatin Modification
Qian Bian, Erika C. Anderson, Katjuša Brejc, and Barbara J. Meyer

Polytene Chromosome Structure and Somatic Genome Instability
Allan C. Spradling

Heterochromatin, Errors, And Damage

Symmetry from Asymmetry or Asymmetry from Symmetry?
Elizabeth W. Kahney, Rajesh Ranjan, Ryan J. Gleason, and Xin Chen

Function of Junk: Pericentromeric Satellite DNA in Chromosome Maintenance
Madhav Jagannathan and Yukiko M. Yamashita

Homologous Recombination and Replication Fork Protection: BRCA2 and More!
Weiran Feng and Maria Jasin

Fork Protection and Therapy Resistance in Hereditary Breast Cancer
Sharon B. Cantor and Jennifer A. Calvo

Summary

David Pellman
Dorcas Cummings Lecture

David Page
Conversations at the Symposium

Marisa Bartolomei

Mónica Bettencourt-Dias

Kerry Bloom

Iain Cheeseman

Monica P. Colaiácovo

Bernard de Massy

Arshad Desai

Daniel Durocher

Steve Henikoff

Martin Hetzer

Ian Hickson

Maria Jasin

Leonid Mirny

Timothy Mitchison

Tim Stearns

Aaron Straight

Yukiko Yamashita

Author Index
Subject Index
   

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Chromosome Segregation and Structure

(Cold Spring Harbor Symposia on Quantitative Biology LXXXII)

Subject Area(s):  Cell BiologyGeneticsCancer Biology

Edited by David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

Due July 2018 • 400 pages (approx.), illustrated, index
Hardcover • $318 254.40
ISBN  978-1-621822-86-8
You save: 20%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

This title also available in: Paperback

  •     Description    
  •     Contents    

Description

The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. The topics covered at the meeting included: Meiosis; Mitosis; Chromosome Segregation; Centrosomes and Centrioles; Ploidy, Chromosome Segregation Errors & Disease; Asymmetric Cell Division; Nuclear Architecture; Chromosome Structure and Condensation; Sister Chromatid Cohesion; Genome Stability; and Germ Cells. Numerous speakers participated in interviews during the course of the Symposium week and transcripts of those discussions and the Dorcas Cummings lecture by David Page are included.

Contents

Symposium Participants
Foreword
Chromatin, Histones, And Instability

Shaping Chromatin in the Nucleus: The Bricks and the Architects
David Sitbon, Katrina Podsypanina, Tejas Yadav, and Genevieve Almouzni

On the Importance of Satellite Sequence Repression for Genome Stability
Peter Zeller and Susan M. Gasser

Structure and Epigenetic Regulation of Chromatin Fibers
Ping Chen and Guohong Li

Chromosome Biology and Genome Architecture

The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure
Sarah C. Hsu and Gerd A. Blobel

Emerging Evidence of Chromosome Folding by Loop Extrusion
Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, and Leonid A. Mirny

SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches
Prabhakar R. Gudla, Koh Nakayama, Gianluca Pegoraro, and Tom Misteli

Centromeres and Kinetochores

Remarkable Evolutionary Plasticity of Centromeric Chromatin
Steven Henikoff, Jitendra Thakur, Sivakanthan Kasinathan, and Paul B. Talbert

Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation
Simon Jenni, Yoana N. Dimitrova, Roberto Valverde, Stephen M. Hinshaw, and Stephen C. Harrison

Aurora A Kinase Function at Kinetochores
Jennifer DeLuca

RotoStep: A Chromosome Dynamics Simulator Reveals Mechanisms of Loop Extrusion
Josh Lawrimore, Brandon Friedman, Ayush Doshi, and Kerry Bloom

Taming the Beast: Control of APC/CCdc20-Dependent Destruction
Pablo Lara-Gonzalez, Taekyung Kim, and Arshad Desai

Organizing Chromosomes during Segregation

Noncanonical Biogenesis of Centrioles and Basal Bodies
Catarina Nabais, Sónia Gomes Pereira, and Mónica Bettencourt-Dias

Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer
Erich A. Nigg, Dominik Schnerch, and Olivier Ganier

The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules
Jennifer T. Wang and Tim Stearns

Mitotic Chromosome Assembly In Vitro: Functional Cross Talk between Nucleosomes and Condensins
Keishi Shintomi and Tatsuya Hirano

Mitosis and Cell Cycle

Spindle-to-Cortex Communication in Cleaving Frog Eggs
Timothy J. Mitchison and Christine M. Field

Nucleosome-Dependent Pathways That Control Mitotic Progression
Hironori Funabiki, Christopher Jenness, and Christian Zierhut

Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
Kata Sarlós, Andreas Biebricher, Erwin J.G. Petermann, Gijs J.L. Wuite, and Ian D. Hickson

Low-Level, Global Transcription during Mitosis and Dynamic Gene Reactivation during Mitotic Exit
Katherine C. Palozola, Hong Liu, Dario Nicetto, and Kenneth S. Zaret

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates
Stephen C. West and Ying Wai Chan

Meiosis

Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals
So I. Nagaoka and Mitinori Saitou

Regulation of Crossover Frequency and Distribution during Meiotic Recombination
Takamune T. Saito and Monica P. Colaiácovo

Emerging Roles of the Ubiquitin-Proteasome System in the Regulation of Meiotic Recombination
Neil Hunter

Cellular and Molecular Mechanisms of Centromere Drive
Michael A. Lampson and Ben E. Black

Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I
Seira Miyazaki, Jihye Kim, Takeshi Sakuno, and Yoshinori Watanabe

Germ Cells, Imprinting, Gene Dosage, and Regulation

Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease and Evolution
Rafael Galupa and Edith Heard

Dynamic Control of Chromosome Topology and Gene Expression by a Chromatin Modification
Qian Bian, Erika C. Anderson, Katjuša Brejc, and Barbara J. Meyer

Polytene Chromosome Structure and Somatic Genome Instability
Allan C. Spradling

Heterochromatin, Errors, And Damage

Symmetry from Asymmetry or Asymmetry from Symmetry?
Elizabeth W. Kahney, Rajesh Ranjan, Ryan J. Gleason, and Xin Chen

Function of Junk: Pericentromeric Satellite DNA in Chromosome Maintenance
Madhav Jagannathan and Yukiko M. Yamashita

Homologous Recombination and Replication Fork Protection: BRCA2 and More!
Weiran Feng and Maria Jasin

Fork Protection and Therapy Resistance in Hereditary Breast Cancer
Sharon B. Cantor and Jennifer A. Calvo

Summary

David Pellman
Dorcas Cummings Lecture

David Page
Conversations at the Symposium

Marisa Bartolomei

Mónica Bettencourt-Dias

Kerry Bloom

Iain Cheeseman

Monica P. Colaiácovo

Bernard de Massy

Arshad Desai

Daniel Durocher

Steve Henikoff

Martin Hetzer

Ian Hickson

Maria Jasin

Leonid Mirny

Timothy Mitchison

Tim Stearns

Aaron Straight

Yukiko Yamashita

Author Index
Subject Index
   

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Ras and Cancer in the 21st Century


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell Biology

Edited by Linda Van Aelst, Cold Spring Harbor Laboratory; Julian Downward, The Francis Crick Institute; Frank McCormick, University of California, San Francisco

Due July 2018 • 250 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621822-21-9
You save: 30%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

  •     Description    
  •     Contents    

Description

Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered “undruggable.”

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids).

The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.

Contents

Preliminary
The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants
Jillian A. Parker and Carla Mattos
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Andrew M. Waters and Channing J. Der
Ras and MAPK
Neal Rosen
P13K: A Crucial Piece in the RAS Signaling Puzzle
Agata Adelajda Krygowska and Esther Castellano
From Ras to Rap and Back, A Journey of 35 Years
Johannes L. Bos
Targeting Ras with Macromolecules
Dehua Pei, Kuangyu Chen, and Hui Liao
Post-Translational Modifications of RAS Proteins
Ian Ahearn, Mo Zhou, and Mark Philips
Targeting the MAPK Pathway in RAS Mutant Cancers
Sarah G. Hymowitz and Shiva Malek
Ras-Mediated Activation of the Raf Family Kinases
Elizabeth M. Terrell and Deborah K. Morrison
GAP Structure
Klaus Scheffzek
Synthetic Lethal Vulnerabilities in KRAS-mutant Cancers
Andrew J. Aguirre and William C. Hahn
Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras
Anica Wandler and Kevin Shannon
The Interdependent Activation of SOS and Ras
Pradeep Bandaru, Yasushi Kondo, and John Kuriyan
Genetically Engineered Mouse Models of K-RAS Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets
Matthias Drosten, Carmen Guerra, and Mariano Barbacid
Kras in Organoids
Derek Cheng and David Tuveson
Ras and the Plasma Membrane: A Complicated Relationship
Yong Zhou, Priyanka Prakash, Alemayehu A. Gorfe, and John F. Hancock
Kras and Tumor Immunity: Friend or Foe?
Jane Cullis, Shipra Das, and Dafna Bar-Sagi
Efforts to Develop KRAS Inhibitors
Matthew Holderfield
Nf1 Therapy
Karen Cichowski
MRAS: A Close but Understudied Member of the Ras family
Lucy C. Young and Pablo Rodriguez-Viciana
Index
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