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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2019 • ISSN 0890-9369; Volume 32 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 24 semimonthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetical Society of Great Britain.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2019 • ISSN: 1088-9051; Volume 28 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2019 • ISSN 1549-5485; Volume 26; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 20187, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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RNA [Journal]
 
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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2019 • ISSN: 2157-1422; Volume 8 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2019 • ISSN: 1943-0264; Volume 10 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
Journal Subscription

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Description

A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal�s website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library�s HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2019 • ISSN: 1559-6095; Volume 13; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

Read within Top Institutions and Companies Such as:

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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2019 • ISSN 1355-8382; Volume 24; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2018, 12 monthly issues
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Description

RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyHuman Biology and Disease

Edited by Guy P. Richardson, University of Sussex; Christine Petit, Institut Pasteur

Download a Free Excerpt from Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies:

Preface
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
Index


Due February 2019 • 300 pages (approx.), illus, index
Paperback • $135 94.50
ISBN  978-1-621822-79-0
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  •     Description    
  •     Contents    

Description

The cochlea is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with remarkable precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular machinery that is responsible for cochlear function and describes recent advances in understanding and treating various forms of hearing loss. The contributors focus on the highly specialized cells that are critical for auditory transduction—the hair cells—and their unique molecular and biomechanical characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, synaptic connections, and resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed.

In addition, the authors examine the epidemiology and pathology of hearing loss and emerging therapeutic strategies (e.g., optical cochlear implants) for addressing it. This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.

Contents

Preliminary
Evolution of the Cochlea from a Functional Perspective
Christine K&uoml;ppl and Geoffrey A. Manley
Cochlear Frequency Tuning and Otoacoustic Emissions
Christopher A. Shera and Karolina K. Charaziak
Development and Patterning of the Cochlea
Mireille Montcouquiol and Matt Kelley
Hair-Bundle Links: Genetics as the Gateway to Function
Guy P. Richardson and Christine Petit
TMC Channels in Cochlear Hair Cells: Roles in Hearing and Deafness
Jeff Holt and David Corey
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
Christopher L. Cunningham and Ulrich Müller
Molecular Composition of Vestibular Hair Bundles
Jocelyn F. Krey and Peter G. Barr-Gillespie
The Tectorial Membrane: Mechanical Properties and Functions
Dennis M. Freeman and Jon Blake Sellon
Inner Hair Cell Afferent Synapses: Molecular Mechanisms
Walter Marcotti and Saaid Safieddine
Outer Hair Cells and Electromotility
Jonathan Ashmore
Efferent Inhibition of the Cochlea
Paul Albert Fuchs and Amanda M. Lauer
Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function
Fabio Mammano
Epidemiology of Deafness
Richard J. Smith
Ototoxicity: Etiology, Mechanisms and Protective Strategies
Corné J. Kros and Peter S. Steyger
Interactions Between Macrophages and the Sensory Cells of the Inner Ear
Mark E. Warchol
Age-Related Hearing Loss
Sally Dawson and Michael Bowl
Stem Cell-Based Therapies
Stefan Heller
Gene Therapies
Lawrence Lustig
Optogenetically Based Cochlear Implants
Tobias Moser
Biomechanical Properties of the Sensory Hair Bundle
Dolores Bozovic
Index
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Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies

The cochlea is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with remarkable precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular machinery that is responsible for cochlear function and describes recent advances in understanding and treating various forms of hearing loss. The contributors focus on the highly specialized cells that are critical for auditory transduction—the hair cells—and their unique molecular and biomechanical characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, synaptic connections, and resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed.

In addition, the authors examine the epidemiology and pathology of hearing loss and emerging therapeutic strategies (e.g., optical cochlear implants) for addressing it. This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.

Download a Free Excerpt from Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies:

Preface
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
Index

More INFO Below
Description
Contents
   

© 2019 • 300 pages (approx.), illus, index
Paperback • $75.00 • ISBN 978-1-621822-79-0


 

Description

The cochlea is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with remarkable precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular machinery that is responsible for cochlear function and describes recent advances in understanding and treating various forms of hearing loss. The contributors focus on the highly specialized cells that are critical for auditory transduction—the hair cells—and their unique molecular and biomechanical characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, synaptic connections, and resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed.

In addition, the authors examine the epidemiology and pathology of hearing loss and emerging therapeutic strategies (e.g., optical cochlear implants) for addressing it. This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.

 
Add To Cart  Add this Title to Order List 
 

Contents

Preliminary
Evolution of the Cochlea from a Functional Perspective
Christine K&uoml;ppl and Geoffrey A. Manley
Cochlear Frequency Tuning and Otoacoustic Emissions
Christopher A. Shera and Karolina K. Charaziak
Development and Patterning of the Cochlea
Mireille Montcouquiol and Matt Kelley
Hair-Bundle Links: Genetics as the Gateway to Function
Guy P. Richardson and Christine Petit
TMC Channels in Cochlear Hair Cells: Roles in Hearing and Deafness
Jeff Holt and David Corey
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
Christopher L. Cunningham and Ulrich Müller
Molecular Composition of Vestibular Hair Bundles
Jocelyn F. Krey and Peter G. Barr-Gillespie
The Tectorial Membrane: Mechanical Properties and Functions
Dennis M. Freeman and Jon Blake Sellon
Inner Hair Cell Afferent Synapses: Molecular Mechanisms
Walter Marcotti and Saaid Safieddine
Outer Hair Cells and Electromotility
Jonathan Ashmore
Efferent Inhibition of the Cochlea
Paul Albert Fuchs and Amanda M. Lauer
Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function
Fabio Mammano
Epidemiology of Deafness
Richard J. Smith
Ototoxicity: Etiology, Mechanisms and Protective Strategies
Corné J. Kros and Peter S. Steyger
Interactions Between Macrophages and the Sensory Cells of the Inner Ear
Mark E. Warchol
Age-Related Hearing Loss
Sally Dawson and Michael Bowl
Stem Cell-Based Therapies
Stefan Heller
Gene Therapies
Lawrence Lustig
Optogenetically Based Cochlear Implants
Tobias Moser
Biomechanical Properties of the Sensory Hair Bundle
Dolores Bozovic
Index
 

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Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies
   

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Protein Homeostasis, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Proteins and ProteomicsHuman Biology and Disease

Edited by Jeffery W. Kelly, The Scripps Research Institute, Franz-Ulrich Hartl, Max Planck Institute of Biochemistry; Richard I. Morimoto, Northwestern University

Due March 2019 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621822-96-7
You save: 30%
You will receive free shipping on this item at checkout.
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  •     Description    
  •     Contents    

Description

Correct folding of proteins is critical for cell function, and accumulation of misfolded proteins is a feature of a number of neurodegenerative conditions. This book examines the mechanisms that ensure proper protein folding of proteins and dispose of misfolded proteins and how this may go awry in disease.

Contents

Preliminary
Preface
Predictions of Aggregation Propensities of Proteins
Michele Vendruscolo and Pietro Sormanni
Structural Insights in Amyloids and Prion Diseases
David Eisenberg
Functional Amyloids
Daniel Otzen and Roland Riek
Amyloid Phenomenon and Significance for Human Disease
Chris Dobson
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein Folding Capacity of the Endoplasmic Reticulum
G. Elif Karagöz, Diego Acosta-Alvear, and Peter Walter
Early Events in the Endoplasmic Reticulum Unfolded Protein Response (UPS)
Steffen Preissler and David Ron
Spatial Quality Control
Ramanujan Hegde
Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum (ER) Homeostasis
Ryo Ushioda and Kazuhiro Nagata
Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases
Patrick G. Needham, Christopher J. Guerriero, and Jeffrey L. Brodsky
Mitochondrial Proteolysis and Metabolic Control
Sofia Ahola, Thomas Langer, and Thomas MacVicar
Signaling and Regulation of the Mitochondrial Unfolded Protein Response
Nandhitha Uma Naresh and Cole M. Haynes
Protein Folding and Misfolding in the Cytoplasm
F. Ulrich Hartl and Mark Hipp
Modulation of Amyloid States by Molecular Chaperones
Anne Wentink, Carmen Nussbaum-Krammer, and Bernd Bukau
Chaperone Interactions at the Ribosome
Elke Deuerling, Martin Gamerdinger, and Stefan Kreft
Ubiquitin Proteasome and the Remodeling of Life
Daniel Finley
Autophagy lysosomal pathways & neurodegeneration
Steve Finkbeiner
The Nuclear and DNA-Associated Molecular Chaperone Network
Zlata Gvozdenov, Janhavi Kolhe, and Brian C. Freeman
Structure, Function, and Regulation of the Hsp90 Machinery
Maximilian M. Biebl and Johannes Buchner
Mechanisms of Small Heat Shock Proteins
Maria K. Janowska, Hannah E.R. Baughman, Christopher N. Woods, and Rachel E. Klevit
Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase
James Shorter and Daniel R. Southworth
Role of Polyphosphate in Amyloidogenic Processes
Justine Lempart and Ursula Jakob
Protein Phase Separation as a Stress Survival Strategy
Titus M. Franzmann and Simon Alberti
Tailoring of Proteostasis Networks with Heat Shock Factors
Jenny Joutsen and Lea Sistonen
Cell Non-Autonomous Regulation of Proteostasis in Aging and Disease
Richard I. Morimoto
Viral Infections as a Proteostasis Disease
Judith Frydman
Restoring Cellular Function by Proteostasis Regulators
Jeffery W. Kelly
Hsp90 Inhibitors and Cancer
Gabriela Chiosis
Proteome-scale Mapping of Perturbed Proteostasis in Living Cells
Vikram Khurana and Joan H. Swan
Index

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