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RNA Worlds: New Tools for Deep Exploration

RNA (ribonucleic acid) molecules drive much of cellular action. Messenger RNA (mRNA) relays genetic information from DNA to ribosomes to direct the formation of proteins. At the same time, noncoding RNAs act as enzymes, scaffolds, and regulatory molecules, contributing greatly to the regulation of gene activity, RNA splicing, protein synthesis, and even DNA replication.

This new edition of the highly successful RNA Worlds series focuses on emerging tools for analysis of RNA biology and how these tools are driving our understanding of RNA structure and function. The contributors review new approaches for imaging RNA molecules in cells, techniques for analyzing the behavior of single RNA molecules in vitro and in vivo, transcriptome-wide analyses, and novel methods for determining the structure of RNA and RNP (ribonucleoprotein) complexes. They discuss the insights these provide into the transcription and splicing machinery, ribosomes, reverse transcriptases, and subcellular structures such as stress granules.

Also included are chapters exploring CRISPR editing, RNA switches for use in synthetic biology, and development of novel drugs targeting pathogenic RNA structures. In addition, the book covers recent insights into the primordial RNA World, including protocells and homochirality. It will therefore be of interest not only to biochemists and molecular biologists but to evolutionary biologists pondering the emergence of life on Earth.

Download a Free Excerpt from RNA Worlds, New Tools for Deep Exploration:

Preface
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Index

More INFO Below
Description
Contents
   

© 2019 • 559 pages, illustrated (153 color and 13 B&W), index
Hardcover • $147.42 • ISBN 978-1-621822-24-0


 

Description

RNA (ribonucleic acid) molecules drive much of cellular action. Messenger RNA (mRNA) relays genetic information from DNA to ribosomes to direct the formation of proteins. At the same time, noncoding RNAs act as enzymes, scaffolds, and regulatory molecules, contributing greatly to the regulation of gene activity, RNA splicing, protein synthesis, and even DNA replication.

This new edition of the highly successful RNA Worlds series focuses on emerging tools for analysis of RNA biology and how these tools are driving our understanding of RNA structure and function. The contributors review new approaches for imaging RNA molecules in cells, techniques for analyzing the behavior of single RNA molecules in vitro and in vivo, transcriptome-wide analyses, and novel methods for determining the structure of RNA and RNP (ribonucleoprotein) complexes. They discuss the insights these provide into the transcription and splicing machinery, ribosomes, reverse transcriptases, and subcellular structures such as stress granules.

Also included are chapters exploring CRISPR editing, RNA switches for use in synthetic biology, and development of novel drugs targeting pathogenic RNA structures. In addition, the book covers recent insights into the primordial RNA World, including protocells and homochirality. It will therefore be of interest not only to biochemists and molecular biologists but to evolutionary biologists pondering the emergence of life on Earth.

 
Add To Cart  Add this Title to Order List 
 

Contents

Preface
Foreword to the First Edition of The RNA World
Francis Crick
Prologue to the First Edition of The RNA World
James D. Watson
IMAGING RNA BIOLOGY
Imaging the Life and Death of mRNAs in Single Cells
Jeffrey A. Chao and Timothée Lionnet
Quantifying Single mRNATranslation Kinetics in Living Cells
Tatsuya Morisaki and Timothy J. Stasevich
Illuminating Genomic Dark Matter with RNA Imaging
Arjun Raj and John L. Rinn
Principles of Stress Granules Revealed by Imaging Approaches
Briana Van Treeck and Roy Parker
COMPUTING RNA BIOLOGY: TRANSCRIPTOME-WIDE ANALYSES
Nascent RNA and the Coordination of Splicing with Transcription
Karla M. Neugebauer
U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation
Christopher C. Venters, Jung-Min Oh, Chao Di, Byung Ran So, and Gideon Dreyfuss
Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression
Patrick McDonel and Mitchell Guttman
What Are 3´ UTRs Doing?
Christine Mayr
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA
Bastian Linder and Samie R. Jaffrey
Mapping the dsRNA World
Daniel P. Reich and Brenda L. Bass
PROBING RNA STRUCTURE AND PROTEIN INTERACTIONS
Technique Development for Probing RNA Structure In Vivo and Genome-Wide
Philip C. Bevilacqua and Sarah M. Assmann
The RNA Base-Pairing Problem and Base-Pairing Solutions
Zhipeng Lu and Howard Y. Chang
Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome
Chun Kit Kwok, Giovanni Marsico, and Shankar Balasubramanian
Linking RNA Sequence, Structure, and Function on Massively Parallel High-Throughput Sequencers
Sarah K. Denny and William J. Greenleaf
The Future of Cross-Linking and Immunoprecipitation (CLIP)
Jernej Ule, Hun-Way Hwang, and Robert B. Darnell
Principles and Practices of Hybridization Capture Experiments to Study Long Noncoding RNAs That Act on Chromatin
Matthew D. Simon and Martin Machyna
ENGINEERING RNA BIOLOGY
CRISPR Tools for Systematic Studies of RNA Regulation
Jesse Engreitz, Omar Abudayyeh, Jonathan Gootenberg, and Feng Zhang
Drugging the RNA World
Matthew D. Disney, Brendan G. Dwyer, and Jessica L. Childs-Disney
RNA Switches for Synthetic Biology
Calvin M. Schmidt and Christina D. Smolke
SOLVING RNP STRUCTURES
Extensions, Extra Factors, and Extreme Complexity: Ribosomal Structures Provide Insights into Eukaryotic Translation
Melanie Weisser and Nenad Ban
Structural Biology of Telomerase
Yaqiang Wang, Lukas Sušac, and Juli Feigon
Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast
Clemens Plaschka, Andrew J. Newman, and Kiyoshi Nagai
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Berthold Kastner, Cindy L. Will, Holger Stark, and Reinhard Lührmann
Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome
Chuangye Yan, Ruixue Wan, and Yigong Shi
Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes
Alexander Leitner, Georg Dorn, and Frédéric H.-T. Allain
Group II Intron RNPs and Reverse Transcriptases: From Retroelements to Research Tools
Marlene Belfort and Alan M. Lambowitz
Alternate RNA Structures
Marie Teng-Pei Wu and Victoria D’Souza
EXAMINING SINGLE RNA MOLECULES IN VITRO
The Story of RNA Folding, as Told in Epochs
Daniel Herschlag, Steve Bonilla, and Namita Bisaria
Coming Together: RNAs and Proteins Assemble under the Single-Molecule Fluorescence Microscope
Ameya P. Jalihal, Paul E. Lund, and Nils G. Walter
Relating Structure and Dynamics in RNA Biology
Kevin P. Larsen, Junhong Choi, Arjun Prabhakar, Elisabetta Viani Puglisi, and Joseph D. Puglisi
Single-Molecule Analysis of Reverse Transcriptase Enzymes
Linnea I. Jansson and Michael D. Stone
EXPLORING THE PRIMORDIAL RNA WORLD
Protocells and RNA Self-Replication
Gerald F. Joyce and Jack W. Szostak
The Origin of Biological Homochirality
Donna G. Blackmond
Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics
Alexander I. Taylor, Gillian Houlihan, and Philipp Holliger
Index
 

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RNA Worlds: New Tools for Deep Exploration
   

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RNA Worlds: New Tools for Deep Exploration


Subject Area(s):  Molecular Biology

Edited by Thomas R. Cech, Howard Hughes Medical Institute; University of Colorado Boulder; Joan A. Steitz, Howard Hughes Medical Institute; Yale University; John F. Atkins, The University of Utah

Download a Free Excerpt from RNA Worlds, New Tools for Deep Exploration:

Preface
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Index


© 2019 • 559 pages, illustrated (153 color and 13 B&W), index
Hardcover • $162 129.60
ISBN  978-1-621822-24-0
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  •     Description    
  •     Contents    

Description

RNA (ribonucleic acid) molecules drive much of cellular action. Messenger RNA (mRNA) relays genetic information from DNA to ribosomes to direct the formation of proteins. At the same time, noncoding RNAs act as enzymes, scaffolds, and regulatory molecules, contributing greatly to the regulation of gene activity, RNA splicing, protein synthesis, and even DNA replication.

This new edition of the highly successful RNA Worlds series focuses on emerging tools for analysis of RNA biology and how these tools are driving our understanding of RNA structure and function. The contributors review new approaches for imaging RNA molecules in cells, techniques for analyzing the behavior of single RNA molecules in vitro and in vivo, transcriptome-wide analyses, and novel methods for determining the structure of RNA and RNP (ribonucleoprotein) complexes. They discuss the insights these provide into the transcription and splicing machinery, ribosomes, reverse transcriptases, and subcellular structures such as stress granules.

Also included are chapters exploring CRISPR editing, RNA switches for use in synthetic biology, and development of novel drugs targeting pathogenic RNA structures. In addition, the book covers recent insights into the primordial RNA World, including protocells and homochirality. It will therefore be of interest not only to biochemists and molecular biologists but to evolutionary biologists pondering the emergence of life on Earth.

Contents

Preface
Foreword to the First Edition of The RNA World
Francis Crick
Prologue to the First Edition of The RNA World
James D. Watson
IMAGING RNA BIOLOGY
Imaging the Life and Death of mRNAs in Single Cells
Jeffrey A. Chao and Timothée Lionnet
Quantifying Single mRNATranslation Kinetics in Living Cells
Tatsuya Morisaki and Timothy J. Stasevich
Illuminating Genomic Dark Matter with RNA Imaging
Arjun Raj and John L. Rinn
Principles of Stress Granules Revealed by Imaging Approaches
Briana Van Treeck and Roy Parker
COMPUTING RNA BIOLOGY: TRANSCRIPTOME-WIDE ANALYSES
Nascent RNA and the Coordination of Splicing with Transcription
Karla M. Neugebauer
U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation
Christopher C. Venters, Jung-Min Oh, Chao Di, Byung Ran So, and Gideon Dreyfuss
Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression
Patrick McDonel and Mitchell Guttman
What Are 3´ UTRs Doing?
Christine Mayr
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA
Bastian Linder and Samie R. Jaffrey
Mapping the dsRNA World
Daniel P. Reich and Brenda L. Bass
PROBING RNA STRUCTURE AND PROTEIN INTERACTIONS
Technique Development for Probing RNA Structure In Vivo and Genome-Wide
Philip C. Bevilacqua and Sarah M. Assmann
The RNA Base-Pairing Problem and Base-Pairing Solutions
Zhipeng Lu and Howard Y. Chang
Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome
Chun Kit Kwok, Giovanni Marsico, and Shankar Balasubramanian
Linking RNA Sequence, Structure, and Function on Massively Parallel High-Throughput Sequencers
Sarah K. Denny and William J. Greenleaf
The Future of Cross-Linking and Immunoprecipitation (CLIP)
Jernej Ule, Hun-Way Hwang, and Robert B. Darnell
Principles and Practices of Hybridization Capture Experiments to Study Long Noncoding RNAs That Act on Chromatin
Matthew D. Simon and Martin Machyna
ENGINEERING RNA BIOLOGY
CRISPR Tools for Systematic Studies of RNA Regulation
Jesse Engreitz, Omar Abudayyeh, Jonathan Gootenberg, and Feng Zhang
Drugging the RNA World
Matthew D. Disney, Brendan G. Dwyer, and Jessica L. Childs-Disney
RNA Switches for Synthetic Biology
Calvin M. Schmidt and Christina D. Smolke
SOLVING RNP STRUCTURES
Extensions, Extra Factors, and Extreme Complexity: Ribosomal Structures Provide Insights into Eukaryotic Translation
Melanie Weisser and Nenad Ban
Structural Biology of Telomerase
Yaqiang Wang, Lukas Sušac, and Juli Feigon
Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast
Clemens Plaschka, Andrew J. Newman, and Kiyoshi Nagai
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Berthold Kastner, Cindy L. Will, Holger Stark, and Reinhard Lührmann
Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome
Chuangye Yan, Ruixue Wan, and Yigong Shi
Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes
Alexander Leitner, Georg Dorn, and Frédéric H.-T. Allain
Group II Intron RNPs and Reverse Transcriptases: From Retroelements to Research Tools
Marlene Belfort and Alan M. Lambowitz
Alternate RNA Structures
Marie Teng-Pei Wu and Victoria D’Souza
EXAMINING SINGLE RNA MOLECULES IN VITRO
The Story of RNA Folding, as Told in Epochs
Daniel Herschlag, Steve Bonilla, and Namita Bisaria
Coming Together: RNAs and Proteins Assemble under the Single-Molecule Fluorescence Microscope
Ameya P. Jalihal, Paul E. Lund, and Nils G. Walter
Relating Structure and Dynamics in RNA Biology
Kevin P. Larsen, Junhong Choi, Arjun Prabhakar, Elisabetta Viani Puglisi, and Joseph D. Puglisi
Single-Molecule Analysis of Reverse Transcriptase Enzymes
Linnea I. Jansson and Michael D. Stone
EXPLORING THE PRIMORDIAL RNA WORLD
Protocells and RNA Self-Replication
Gerald F. Joyce and Jack W. Szostak
The Origin of Biological Homochirality
Donna G. Blackmond
Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics
Alexander I. Taylor, Gillian Houlihan, and Philipp Holliger
Index
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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2018 • ISSN 0890-9369; Volume 32 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 24 semimonthly issues
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Description

Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetical Society of Great Britain.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2018 • ISSN: 1088-9051; Volume 28 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
Journal Subscription

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Description

In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2018 • ISSN 1549-5485; Volume 26; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 20187, 12 online  issues
Journal Subscription

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Description

Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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Genes & Development [Journal]
Genome Research [Journal]
RNA [Journal]
 
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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 2157-1422; Volume 8 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
Journal Subscription

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For a Sample Print Issue Click Here.


 

Description

Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 1943-0264; Volume 10 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2018, 12 monthly issues
Journal Subscription

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For a Sample Print Issue Click Here.


 

Description

A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal�s website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library�s HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2018 • ISSN: 1559-6095; Volume 13; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2018, 12 monthly issues
Journal Subscription

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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2018 • ISSN 1355-8382; Volume 24; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2018, 12 monthly issues
Journal Subscription

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Description

RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Prostate Cancer


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseDiseasesCancer Biology

Edited by Michael M. Shen, Columbia University Medical Center; Mark A. Rubin, Cornell University

Download a Free Excerpt from Prostate Cancer:

Preface
Prostate Cancer Research at the Crossroads
Index


Due December 2018 • 467 pages, illustrated (72 color and 4 B&W), index
Hardcover • $135 94.50
ISBN  978-1-621821-64-9
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  •     Description    
  •     Contents    

Description

Prostate cancer is the most commonly diagnosed cancer in men and causes thousands of deaths annually. Many prostate tumors are slow growing and localized to the prostate, whereas others are more aggressive and spread to other areas of the body (e.g., bones). Work to better understand prostate cancer will lead to improved treatment options and more precise care for patients with this disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the pathogenesis and treatment of prostate cancer. The contributors review the normal development, anatomy, and histology of the prostate; the genetic, lifestyle, and dietary factors associated with prostate cancer risk; and the alterations in the genome, epigenetic landscape, transcriptional networks, and metabolic and signaling pathways that drive oncogenesis. The role of the tumor microenvironment in prostate cancer pathogenesis is covered, as are the molecular mechanisms of metastasis. The authors also discuss how mouse models and patient-derived tissues can be used to study aspects of the disease and accelerate the development of appropriate therapies.

Other topics include methods for diagnosing and monitoring prostate cancer, such as biomarker (e.g., serum PSA) testing, histopathological grading, and anatomical and molecular imaging techniques, as well as treatment options that are currently available and under development. Strategies that may prevent prostate cancer altogether (e.g., chemoprevention) are also described. This volume is therefore a vital reference for all cancer biologists and clinician–scientists concerned with defeating this disease.

Contents

Preface
Foreword
Charles L. Sawyers
Prostate Cancer Research at the Crossroads
Michael M. Shen and Mark A. Rubin
Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann
Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain
The Epidemiology of Prostate Cancer
Claire H. Pernar, Ericka M. Ebot, Kathryn M. Wilson, and Lorelei A. Mucci
Prostate Cancer Germline Variations and Implications for Screening and Treatment
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles
Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck
Histopathology of Prostate Cancer
Peter A. Humphrey
Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities
Levent Trabzonlu, Ibrahim Kulac, Qizhi Zheng, Jessica L. Hicks, Michael C. Haffner, William G. Nelson, Karen S. Sfanos, Onur Ertunc, Tamara L. Lotan, Christopher M. Heaphy, Alan K. Meeker, Srinivasan Yegnasubramanian, and Angelo M. De Marzo
Prostate Stem Cells and Cancer Stem Cells
Jia J. Li and Michael M. Shen
Transcriptional Regulation in Prostate Cancer
David P. Labbé and Myles Brown
Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications
Srinivasan Yegnasubramanian, Angelo M. De Marzo, and William G. Nelson
The Genomics of Prostate Cancer: A Historic Perspective
Mark A. Rubin and Francesca Demichelis
Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero, Jr., Ian M. Thompson, Jr., Michael A. Liss, and Dharam Kaushik
Androgen Signaling in Prostate Cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi
New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, and Wayne D. Tilley
Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies
Loredana Puca, Panagiotis J. Vlachostergios, and Himisha Beltran
DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen
Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson
Metastases in Prostate Cancer Federico La Manna, Sofia Karkampouna, Eugenio Zoni, Marta De Menna, Janine Hensel, George N. Thalmann, and Marianna Kruithof-de Julio
Genetically Engineered Mouse Models of Prostate Cancer in the Postgenomic Era
Juan M. Arriaga and Cory Abate-Shen
Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor
Preclinical and Coclinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi
Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities
Giorgia Zadra and Massimo Loda
Molecular Biomarkers in the Clinical Management of Prostate Cancer
Aaron M. Udager and Scott A. Tomlins
Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmasi, and Robert E. Reiter
Immunotherapy for Prostate Cancer
Nicholas J. Venturini and Charles G. Drake
Treatment of Advanced Prostate Cancer—A Review of Current Therapies and Future Promise
Semini Sumanasuriya and Johann De Bono
Index
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