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The Nucleus, Second Edition


Subject Area(s):  Cell BiologyMolecular BiologyBiochemistry

Edited by Ana Pombo, Max Delbrück Center for Molecular Medicine; Martin W. Hetzer, Salk Institute for Biological Studies; Tom Misteli, National Cancer Institute, NIH

Due October 2021 • 300 pages (approx.), illustrated (75 color), index
Hardcover • $135
ISBN  978-1-621823-89-6

  •     Description    
  •     Contents    

Description

The nucleus of the cell is the control center that contains its DNA. This volume explores how the nucleus is organized, examining how different subcompartments form and interact and the role these play in gene regulation and processes such as splicing of RNA.

Contents

Preliminary
PREFACE
NUCLEAR ENVELOPE
The Nuclear Lamina
Xianrong Wong, Ashley J. Melendez-Perez, and Karen L. Reddy
Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome
Marcela Raices and Maximiliano A. D'Angelo
The Nuclear Pore Complex as a Transcription Regulator
Michael Chas Sumner and Jason Brickner
The Diverse Cellular Functions of Inner Nuclear Membrane Proteins
Sumit Pawar and Ulrike Kutay
PRINCIPLES OF ORGANIZATION
Mechanical Forces in Nuclear Organization
Yekaterina A. Miroshnikova and Sara A. Wickström Liquid–Liquid Phase Separation in Chromatin
Karsten Ripp
The Stochastic Genome and Its Role in Gene Expression
Christopher H. Bohrer and Daniel R. Larson
Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus
Svenja Ulferts, Bina Prajapati, Robert Grosse, and Maria K. Vartiainen
CHROMATIN
Physical Nature of Chromatin in the Nucleus
Kazuhiro Maeshima, Shiori Iida, and Sachiko Tamura
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions
Leonid Mirny and Job Dekker
Uncovering the Principles of Genome Folding by 3D Chromatin Modeling
Asli Yildirim, Lorenzo Boninsegna, Yuxiang Zhan, and Frank Alber
Transcription Factor Dynamics
Feiyue Lu and Timothée Lionnet
Essential Roles for RNA in Shaping Nuclear Organization
Sofia A. Quinodoz and Mitchell Guttman
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture
Andrew S. Belmont
NUCLEAR PROCESSES
The Impact of Space and Time on the Functional Output of the Nucleus
Marcelo Nollmann, Isma Bennabi, Markus Götz, and Thomas Gregor
Mammalian DNA Replication Timing
Athanasios E. Vouzas and David M. Gilbert
Imaging Organization of RNA Processing within the Nucleus
Jeetayu Biswas, Weihan Li, Robert H. Singer, and Robert A. Coleman
PHYSIOLOGICAL PROCESSES AND DISEASE
Chromatin Mechanisms Driving Cancer
Berkley Gryder, Peter C. Scacheri, Thomas Ried, and Javed Khan
Viruses in the Nucleus
Bojana Lucic, Ines J. de Castro, and Marina Lusic
3D or Not 3D: Shaping the Genome During Development
Juliane Glaser and Stefan Mundlos
Epigenetic Reprogramming in Early Animal Development
Zhenhai Du, Ke Zhang, and Wei Xie
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation
François Dossin and Edith Heard
Organization of the Pluripotent Genome
Patrick S.L. Lim and Eran Meshorer
Index