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Hepatitis C Viruses: The Story of a Scientific and Therapeutic Revolution

Subject Area(s):  Infectious DiseasesHuman Biology and DiseaseDiseasesViruses

Edited by Arash Grakoui, Emory University; Jean-Michel Pawlotsky, Hopital Henri Mondor / Universite Paris Est; Glenn Randall, University of Chicago

Due June 2020 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-19-3
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  •     Description    
  •     Contents    


Hepatitis C infects 71 million people worldwide and there is currently no vaccine against the virus that causes the disease (HCV). This volume describes recent advances in our understanding of the biology of HCV and the consequences of infection, as well as ongoing efforts to develop a vaccine and new treatment strategies.


1. HCV: 30 years since its identification
Michael Houghton
2. HCV genetic heterogeneity
Jens Bukh
3. HCV Structure
Joseph Marcotrigiano and Maria Theresa Catanese
4. Cell Culture Systems of HCV Using JFH-1 and Other Strains
Takaji Wakita
5. Animal Models of Hepatitis C Virus Infection
Alexander Ploss and Amit Kapoor
6. Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion
Gisa Gerold, Rebecca Moeller, and Thomas Pietschmann
7. HCV Replication
Ralf Bartenschlager, Keisuke Tabata, and Christopher Neufeldt
8. HCV Assembly and Egress Via Modifications in Host Lipid Metabolic Systems
Kunitada Shimotohno
9. HCV-host interactions in cellular pathogenesis
Qisheng Li and Jake Liang
10. Cellular innate immune control of HCV infection
Michael Gale and Ram Savan
11. Control of HCV infection by NK cells and macrophages
Hugo Rosen & Lucy Golden-Mason
12. T cell control of HCV infection
Chris Walker
13. Role of antibodies in HCV infection
Mansun Law
14. Interferon-free HCV therapy
Jean-Michel Pawlotsky
15. Heptatis C Virus Epidemiology and the Impact of Interferon-free HCV Therapy
Jeffrey V. Lazarus, Elena Roel, and Ahmed M. Elsharkawy
16. Natural History of Hepatic and Extrahepatic HCV Diseases and Impact of Interferon-Free HCV Therapy
Francesco Negro
17. Elimination of hepatitis C as a public health threat
Sophia Schroeder, Alisa Pedrana, Joseph Doyle, Campbell Aitken, and Margaret Hellard
18. Pros and cons of an HCV vaccine
Andrea Cox
19. Future Perspectives
Jean-Michel Pawlotsky, Arash Grakoui, and Glenn Randall