Contents

Symposium Participants

Foreword

Cancer Stem Cells



Normal and Neoplastic Stem Cells

Melissa N. McCracken, Benson M. George, Kevin S. Kao, Kristopher D. Marjon, Tal Raveh, and Irving L. Weissman



Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy

Diwakar R. Pattabiraman and Robert A. Weinberg



Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations

Elizabeth Allen, Rindert Missiaen, and Gabriele Bergers



Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma

Sheila R. Alcantara Llaguno, Xuanhua Xie, and Luis F. Parada



Genetics and Epigenetics



The Enigma of p53

Guillermina Lozano



Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome

Joanna Achinger-Kawecka, Phillippa C. Taberlay, and Susan J. Clark



Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease

John L. Pulice and Cigall Kadoch



The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia

Jae-Seok Roe and Christopher R. Vakoc



Metabolism



Reexamining How Cancer Cells Exploit the Body's Metabolic Resources

Craig B. Thompson and Wilhelm Palm



Autophagy, Metabolism, and Cancer

Jessie Yanxiang Guo and Eileen White



A Time for MYC: Metabolism and Therapy

Chi V. Dang



Beyond the Oncogene Revolution: Four New Ways to Combat Cancer

Thorsten Berger, Mary E. Saunders, and Tak W. Mak



Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer

Robert U. Svensson and Reuben J. Shaw



Targets, Vaccines, and Therapeutics



Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design

Jasreet Hundal, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichael, Adam Coffman, and Elaine R. Mardis



Targeting HIF2 in Clear Cell Renal Cell Carcinoma

Hyejin Cho and William G. Kaelin



BET Bromodomain Proteins as Cancer Therapeutic Targets

Shaokun Shu and Kornelia Polyak



To Prime, or Not to Prime: That Is the Question

Danielle S. Potter and Anthony Letai



Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer

Stefano Annunziato, Marco Barazas, Sven Rottenberg, and Jos Jonkers



Microenvironment and Metastasis



Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications

Hanqiu Zheng, Wenyang Li, and Yibin Kang



Cancer, Oxidative Stress, and Metastasis

Jennifer G. Gill, Elena Piskounova, and Sean J. Morrison



RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers

Najme Faham 
and Alana L. Welm



Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis

Madeleine J. Oudin and Valerie M. Weaver



Models of Cancer



Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets

Saori Furuta and Mina J. Bissell



Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities

Douglas T. Fearon



Modeling Breast Cancer Intertumor and Intratumour Heterogeneity Using Xenografts

Alejandra Bruna, Oscar M. Rueda, and Carlos Caldas



Challenges and Opportunities in Modeling Pancreatic Cancer

Michael E. Feigin and David A. Tuveson



Cancer Genomics and Tumor Heterogeneity



Functional Genomic Characterization of Cancer Genomes

Thomas P. Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L. Hong, Mik Rinne, Andrew J. Aguirre, 
Jesse S. Boehm, and William C. Hahn



How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually 
Exclusive Oncogenic Mutations?

Harold Varmus, Arun M. Unni, and 
William W. Lockwood



A Pipeline for Drug Target Identification and Validation

Eusebio Manchado, Chun-Hao Huang, Nilgun Tasdemir, Darjus F. Tschaharganeh, John E. Wilkinson, and Scott W. Lowe



Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity

David T. Miyamoto, David T. Ting, Mehmet Toner, Shyamala Maheswaran, and Daniel A. Haber



Discovery of Double-Stranded Genomic DNA in Circulating Exosomes

Raghu Kalluri and 
Valerie S. LeBleu



Summary



Moving Closer to Victory

Taru Muranen and Joan S. Brugge



Dorcas Cummings Lecture



Charles Sawyers

Conversations at the Symposium



Gabriele Bergers



Joan Brugge



Karen Cichowski



Susan Clark



Gerard Evan



Daniel Haber



William Kaelin



Raghu Kalluri



Scott Lowe



Guillermina (Gigi) Lozano



David Lyden



Elaine Mardis



Sean Morrison



Benjamin Neel



Luis Parada



Sir Michael Stratton



David Tuveson



Christopher Vakoc



Harold Varmus



Karen Vousden



Valerie Weaver



Robert Weinberg



Eileen White



Author Index

Subject Index