Glia

Click to Enlarge				Glia Subject Area(s): Neurobiology Edited by Ben A. Barres, Stanford University School of Medicine; Marc R. Freeman, Howard Hughes Medical Institute, University of Massachusetts Medical School; Beth Stevens, Boston Children's Hospital, Harvard University Download Free Excerpts from Glia: Preface and Contents Index

				© 2015 • 486 pages, illustrated (83 color, 3 B&W), index Hardcover • $135 ISBN 978-1-621820-27-7

Description Contents Description The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nervous system development, function, and disease. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the development of the major classes of glial cells—astrocytes, oligodendrocytes, Schwann cells, and microglia—and their roles in normal physiology and disease. The contributors describe how glia help establish and refine synaptic connections, maintain the metabolic and ionic milieu of nerve cells, myelinate axons, modulate nerve signal propagation, and contribute to the blood–brain barrier. The biological characteristics of glial cells in vertebrate and invertebrate model systems, including those of Drosophila, Caenorhabditis elegans, and zebrafish, are also covered. The authors also discuss the roles of glia in repair and regeneration, as well as in cancer and neurodegenerative diseases. This volume is therefore a valuable reference for all neurobiologists and biomedical scientists wishing to understand these diverse and dynamic cells. Contents Preface ASTROCYTES Astrocyte Development and Heterogeneity Omer Ali Bayraktar, Luis C. Fuentealba, Arturo Alvarez-Buylla, and David H. Rowitch Astrocytes Control Synapse Formation, Function, and Elimination Won-Suk Chung, Nicola J. Allen, and Cagla Eroglu Astrocyte Regulation of Blood Flow in the Brain Brian A. MacVicar and Eric A. Newman The Astrocyte: Powerhouse and Recycling Center Bruno Weber and L. Felipe Barros Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein Baljit S. Khakh and Ken D. McCarthy The Blood-Brain Barrier Richard Daneman and Alexandre Prat Astrogliosis Michael V Sofroniew How Do Astrocytes Participate in Neural Plasticity? Philip G. Haydon and Maiken Nedergaard OLIGODENDROCYTES AND MYELINATION Oligodendrocyte Development and Plasticity Dwight E. Bergles and William D. Richardson Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System Ben Emery and Q. Richard Lu Oligodendrocytes: Myelination and Axonal Support Mikael Simons and Klaus-Armin Nave SCHWANN CELLS Schwann Cells: Development and Role in Nerve Repair Kristján R. Jessen, Rhona Mirsky, and Alison C. Lloyd The Nodes of Ranvier: Molecular Assembly and Maintenance Matthew N. Rasband and Elior Peles Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells Chien-Ping Ko and Richard Robitaille Perineurial Glia Sarah Kucenas Schwann Cell Myelination James L. Salzer MICROGLIA Origin of Microglia: Current Concepts and Past Controversies Florent Ginhoux and Marco Prinz Microglia Function in Central Nervous System Development and Plasticity Dorothy P. Schafer and Beth Stevens Microglia in Health and Disease Richard M. Ransohoff and Joseph El Khoury GLIA IN SMALL GENETIC MODEL SYSTEMS Drosophila Central Nervous System Glia Marc R. Freeman Glial Development and Function in the Nervous System of Caenorhabditis elegans Shai Shaham Glial Cell Development and Function in Zebrafish David A. Lyons and William S. Talbot DISEASE AND REPAIR Glia Disease and Repair—Remyelination Robin J.M. Franklin and Steven A. Goldman Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia Jerry Silver, Martin E. Schwab, and Phillip G. Popovich Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development Hui Zong, Luis F. Parada, and Suzanne J. Baker Astrocytes in Neurodegenerative Disease Hemali Phatnani and Tom Maniatis Index

Glia

Description

Contents