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Multiple Sclerosis

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and Disease

Edited by Howard L. Weiner, Brigham and Women's Hospital; Vijay K. Kuchroo, Brigham and Women's Hospital

© 2018 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621820-76-5
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Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the myelin sheaths that surround nerve cells, producing a variety of neurological symptoms such as limb weakness and sensory loss. In most cases, the disease progressively worsens over time, leading to severe impairments in mobility and cognition. Various medications may slow this progression, but the disease is currently incurable and unpreventable.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine captures our current understanding of the inflammatory processes that lead to demyelination and neurodegeneration in MS, as well as the treatment options that are available. Contributors discuss the genetic and environmental triggers that may contribute to the initiation of MS and the roles of factors such as B cells, T cells, microglia, astrocytes, and the microbiome in the autoimmune response and disease progression. The various MS subtypes and clinical courses are covered, as are current and potential biomarkers for diagnosing and monitoring the disease.

The authors also examine disease-modifying therapies for MS, including hematopoietic stem cell transplantation, interferon β, glatiramer acetate, monoclonal antibodies (e.g., ocrelizumab), and various oral agents. This volume is therefore an essential reference for not only immunologists and neuroscientists seeking to understand the biological basis of MS, but all physicians and clinician-scientists wishing to treat and ultimately prevent the disease.


Clinical Course of Multiple Sclerosis
Sylvia Klineova and Fred D. Lublin
Multiple Sclerosis Pathology
Hans Lassmann
Lifestyle and Environmental Factors in Multiple Sclerosis
Lars Alfredsson and Tomas Olsson
Genetics and Multiple Sclerosis: An Overview and New Directions
Nikolaos A. Patsopoulos
Magnetic Resonance Imaging in Multiple Sclerosis
Christopher C.T. Hemond and Rohit Bakshi
Experimental Autoimmune Encephalomyelitis as Animal Models of MS
Simon Glatigny and Estelle Bettelli
Neurodegeneration in Progressive Multiple Sclerosis
Graham Campbell and Don Mahad
Microglial Phenotypes and Functions in Multiple Sclerosis
Elaine O’Loughlin, Charlotte Madore, Hans Lassmann, and Oleg Butovsky
Regulation of Astrocyte Functions in MS
Michael A. Wheeler and Francisco J. Quintana
The Gut Microbiome and Multiple Sclerosis
Javier Ochoa-Repáraz, Trevor Kirby, and Lloyd H. Kasper
Effector T Cells in Multiple Sclerosis
Belinda J. Kaskow and Clare Baecher-Allen
The IL-23/TH17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Michael Hiltensperger and Thomas Korn
Regulatory T Cells
Alexandra Kitz, Emily Singer, and David Hafler
The Multiple Roles of B Cells in Multiple Sclerosis (MS) and Their Implications in MS Therapies
Rui Li and Amit Bar-Or
Biomarkers in Multiple Sclerosis
Anu Paul, Manual Comabella, and Roopali Gandhi
Interferon-β for Multiple Sclerosis
Dejan Jakimovski, Channa Kolb, Murali Ramanathan, Robert Zivadinov, and Bianca Weinstock-Guttman
The Evolving Mechanism of Actions of Glatiramer Acetate
Thomas Prod’homme and Scott S. Zamvil
Afsaneh Shirani and Olaf Stüve
Oral Therapies for Multiple Sclerosis
Simon Faissner and Ralf Gold
Alemtuzumab as Treatment for Multiple Sclerosis
Serafeim Katsavos and Alasdair Coles
Daclizumab Therapy for Multiple Sclerosis
Bibiana Bielekova
B Cell Therapies in Multiple Sclerosis
Joseph J. Sabatino Jr., Scott S. Zamvil, and Stephen L. Hauser
Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Multiple Sclerosis
Carolina A. Rush, Harold L. Atkins, and Mark S. Freedman
Multiple Sclerosis in the Future
Howard L. Weiner and Vijay Kuchroo