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Multiple Sclerosis


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and Disease

Edited by Howard L. Weiner, Brigham and Women's Hospital; Vijay K. Kuchroo, Brigham and Women's Hospital

Due April 2018 • 300 pages (approx.), illustrated, index
Hardcover • $135 (click here to price in UK Pounds)
ISBN  978-1-621820-76-5

  •     Description    
  •     Contents    

Description

Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord. The immune system attacks the myelin sheaths that surround and insulate nerve cells, producing a variety of neurological symptoms. This book examines the molecular basis of the condition, the nature of the autoimmune response, and current treatment and vaccine strategies.

Contents

Clinical Course of Multiple Sclerosis
Sylvia Klineova and Fred D. Lublin
Multiple Sclerosis Pathology
Hans Lassmann
Lifestyle and Environmental Factors in Multiple Sclerosis
Lars Alfredsson and Tomas Olsson
Genetics and Multiple Sclerosis: An Overview and New Directions
Nikolaos A. Patsopoulos
Magnetic Resonance Imaging in Multiple Sclerosis
Christopher C.T. Hemond and Rohit Bakshi
Experimental Autoimmune Encephalomyelitis as Animal Models of MS
Simon Glatigny and Estelle Bettelli
Neurodegeneration in Progressive Multiple Sclerosis
Graham Campbell and Don Mahad
Microglial Phenotypes and Functions in Multiple Sclerosis
Elaine O’Loughlin, Charlotte Madore, Hans Lassmann, and Oleg Butovsky
Regulation of Astrocyte Functions in MS
Michael A. Wheeler and Francisco J. Quintana
The Gut Microbiome and Multiple Sclerosis
Javier Ochoa-Repáraz, Trevor Kirby, and Lloyd H. Kasper
Effector T Cells in Multiple Sclerosis
Belinda J. Kaskow and Clare Baecher-Allen
The IL-23/TH17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Michael Hiltensperger and Thomas Korn
Regulatory T Cells
Alexandra Kitz, Emily Singer, and David Hafler
The Multiple Roles of B Cells in Multiple Sclerosis (MS) and Their Implications in MS Therapies
Rui Li and Amit Bar-Or
Biomarkers in Multiple Sclerosis
Anu Paul, Manual Comabella, and Roopali Gandhi
Interferon-β for Multiple Sclerosis
Dejan Jakimovski, Channa Kolb, Murali Ramanathan, Robert Zivadinov, and Bianca Weinstock-Guttman
The Evolving Mechanism of Actions of Glatiramer Acetate
Thomas Prod’homme and Scott S. Zamvil
Natalizumab
Afsaneh Shirani and Olaf Stüve
Oral Therapies for Multiple Sclerosis
Simon Faissner and Ralf Gold
Alemtuzumab as Treatment for Multiple Sclerosis
Serfeim Katsavos and Alasdair Coles
Daclizumab Therapy for Multiple Sclerosis
Bibiana Bielekova
B Cell Therapies in Multiple Sclerosis
Joseph J. Sabatino Jr., Scott S. Zamvil, and Stephen L. Hauser
Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Multiple Sclerosis
Carolina A. Rush, Harold L. Atkins, and Mark S. Freedman
Multiple Sclerosis in the Future
Howard L. Weiner and Vijay Kuchroo
Index