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Prostate Cancer

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseDiseasesCancer Biology

Edited by Michael M. Shen, Columbia University Medical Center; Mark A. Rubin, Cornell University

Due July 2018 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621821-64-9
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  •     Description    
  •     Contents    


Prostate cancer is the second most common type of cancer and affects millions of individuals worldwide. This volume reviews our understanding of the disease, its progression, and new therapeutic approaches.


Charles Sawyers
1. Introduction
Michael Shen and Mark Rubin
2. Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann
3. Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain
4. The Epidemiology of Prostate Cancer
Claire Pernar, Ericka Ebot, Kathryn M. Wilson, and Lorelei A. Mucci
5. Prostate Cancer Germline Variations and Implications for Screening and Treatment
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles
6. Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck
7. Stem Cells and Cancer Stem Cells
Michael Shen
8. Pre-neoplastic Lesions
Angelo DeMarzo
9. Histopathology of Prostate Cancer
Peter A. Humphrey
10. Genomics
Mark Rubin
11. Transcriptional Regulation in Prostate Cancer
David P. Labbé and Myles Brown
12. Epigenetics
Srinivasan Yegnasubramanian
13. Androgen signaling in prostate cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi
14. New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, and Wayne D. Tilley
15. DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen
16. Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero Jr., Ian M. Thompson Jr., Michael A. Liss, and Dharam Kaushik
17. Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson
18. Genetically Engineered Mouse Models of Prostate Cancer in the Post-Genomic Era
Juan M. Arriaga and Cory Abate-Shen
19. Pre-Clinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor
20. Preclinical and Co-Clinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi
21.The Genomics of Prostate Cancer: An Historic Perspective
Mark A. Rubin and Francesca Demichelis
22. Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities
Giorgia Zadra and Massimo Loda
23. Metastases in Prostate Cancer
Federico La Manna, Sofia Karkampouna, Eugenio Zoni, Marta De Menna, Janine Hensel, George N. Thalmann, and Marianna Kruithof-de Julio
24. Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models and Therapy
Loredana Puca, Panagiotis J. Vlachosterogios, and Himisha Beltran
25. Molecular biomarkers in the clinical management of prostate cancer
Aaron M. Udager and Scott A. Tomlins
26. Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmalsi, and Robert E. Reiter
27. Immunotherapy
Charles Drake
28. Treatment of Advanced Prostate Cancer; A Review of Current Therapies and Future Promise
Semini Sumanasuriya and Johann De Bono