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Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyHuman Biology and Disease

Edited by Guy P. Richardson, University of Sussex; Christine Petit, Institut Pasteur

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Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex

Due February 2019 • 300 pages (approx.), illus, index
Paperback • $135 94.50
ISBN  978-1-621822-79-0
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  •     Description    
  •     Contents    


The cochlea is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with remarkable precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular machinery that is responsible for cochlear function and describes recent advances in understanding and treating various forms of hearing loss. The contributors focus on the highly specialized cells that are critical for auditory transduction—the hair cells—and their unique molecular and biomechanical characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, synaptic connections, and resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed.

In addition, the authors examine the epidemiology and pathology of hearing loss and emerging therapeutic strategies (e.g., optical cochlear implants) for addressing it. This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician–scientists seeking new approaches to alleviate hearing impairments.


Evolution of the Cochlea from a Functional Perspective
Christine K&uoml;ppl and Geoffrey A. Manley
Cochlear Frequency Tuning and Otoacoustic Emissions
Christopher A. Shera and Karolina K. Charaziak
Development and Patterning of the Cochlea
Mireille Montcouquiol and Matt Kelley
Hair-Bundle Links: Genetics as the Gateway to Function
Guy P. Richardson and Christine Petit
TMC Channels in Cochlear Hair Cells: Roles in Hearing and Deafness
Jeff Holt and David Corey
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
Christopher L. Cunningham and Ulrich Müller
Molecular Composition of Vestibular Hair Bundles
Jocelyn F. Krey and Peter G. Barr-Gillespie
The Tectorial Membrane: Mechanical Properties and Functions
Dennis M. Freeman and Jon Blake Sellon
Inner Hair Cell Afferent Synapses: Molecular Mechanisms
Walter Marcotti and Saaid Safieddine
Outer Hair Cells and Electromotility
Jonathan Ashmore
Efferent Inhibition of the Cochlea
Paul Albert Fuchs and Amanda M. Lauer
Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function
Fabio Mammano
Epidemiology of Deafness
Richard J. Smith
Ototoxicity: Etiology, Mechanisms and Protective Strategies
Corné J. Kros and Peter S. Steyger
Interactions Between Macrophages and the Sensory Cells of the Inner Ear
Mark E. Warchol
Age-Related Hearing Loss
Sally Dawson and Michael Bowl
Stem Cell-Based Therapies
Stefan Heller
Gene Therapies
Lawrence Lustig
Optogenetically Based Cochlear Implants
Tobias Moser
Biomechanical Properties of the Sensory Hair Bundle
Dolores Bozovic