Molecular Approaches to Reproductive and Newborn Medicine

Click to Enlarge				Molecular Approaches to Reproductive and Newborn Medicine Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Biology in Society; Genomics; Genetics Edited by Diana W. Bianchi, Tufts University School of Medicine; Errol Norwitz, Tufts University School of Medicine Molecular Approaches to Reproductive and Newborn Medicine *Download Free Excerpts from Molecular Approaches to Reproductive and Newborn Medicine:* Preface Index

				© 2015 • 416 pages, illustrated (51 color, 12 B&W), index Hardcover • ~~$135~~ 94.50 ISBN 978-1-621820-89-5 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description The development of an infant, from conception to the postnatal period, involves the dynamic coordination of numerous biological factors in the mother, father, and fetus. The use of rapid and sensitive methods to probe these factors has made a remarkable impact on reproductive and neonatal medicine. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our current understanding of the molecular mechanisms involved in conception, pregnancy, placental development, labor, and birth, and how molecular techniques are being applied to reproductive and newborn health. The contributors discuss the gene expression profiles and epigenetic characteristics of sperm, the ovary, the endometrium, and the placenta, as well as the molecules involved in feto-maternal communication, including various endocrine, vascular, and immune factors. They also consider how we can harness this knowledge to improve fertility, conception rates, and embryo implantation success, and reduce pregnancy complications such as recurrent loss, preterm birth, and preeclampsia, thus leading to healthy, full-term pregnancies. The authors also review innovative technologies to screen for and diagnose genetic disorders in fetuses and neonates and the social and ethical dilemmas these pose. The volume is therefore an indispensable reference for all scientists and physicians interested in deepening our understanding of human reproductive biology and translating that knowledge to improve the care of pregnant women and their newborns. Contents Preface MOLECULAR ASPECTS OF REPRODUCTIVE DEVELOPMENT AND GAMETOGENESIS MicroRNA in Ovarian Biology and Disease Lynda K. McGinnis, Lacey J. Luense, and Lane K. Christenson Confrontation, Consolidation, and Recognition: The Oocyte’s Perspective on the Incoming Sperm David Miller Intergenerational Transfer of Epigenetic Information in Sperm Oliver J. Rando The Role of HOX Genes in Female Reproductive Tract Development, Adult Function, and Fertility Hongling Du and Hugh S. Taylor MOLECULAR ASPECTS OF FERTILIZATION AND IMPLANTATION Human Endometrial Transcriptomics: Implications for Embryonic Implantation Eva Gómez, Maria Ruíz-Alonso, Jose Miravet, and Carlos Simón A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies Monica A. Mainigi, Carmen Sapienza, Samantha Butts, and Christos Coutifaris MOLECULAR ASPECTS OF PLACENTAL DEVELOPMENT Molecular Cross-Talk at the Feto-Maternal Interface Gendie E. Lash Placental Extracellular Vesicles and Feto-Maternal Communication Mancy Tong and Lawrence (Larry) W. Chamley The Function of TrophomiRs and Other MicroRNAs in the Human Placenta Yoel Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, Avraham Bayer, and Carolyn B. Coyne The Human Placental Methylome Wendy P. Robinson and E. Magda Price MOLECULAR ASPECTS OF NORMAL PREGNANCY AND DELIVERY The Perinatal Microbiome and Pregnancy: Moving Beyond the Vaginal Microbiome Amanda L. Prince, Derrick M. Chu, Maxim D. Seferovic, Kathleen M. Antony, Jun Ma, and Kjersti M. Aagaard Molecular Regulation of Parturition: A Myometrial Perspective Nora E. Renthal, Koriand’r C. Williams, Alina P. Montalbano, Chien-Cheng Chen, Lu Gao, and Carole R. Mendelson Molecular Regulation of Parturition: The Role of the Decidual Clock Errol R. Norwitz, Elizabeth A. Bonney, Victoria V. Snegovskikh, Michelle A. Williams, Mark Phillippe, Joong Shin Park, and Vikki M. Abrahams MOLECULAR ASPECTS OF ABNORMAL PREGNANCY Genetic Considerations in Recurrent Pregnancy Loss Kassie J. Hyde and Danny J. Schust Genomics of Preterm Birth Kayleigh A. Swaggart, Mihaela Pavlicev, and Louis J. Muglia Molecular Mechanisms of Preeclampsia Tammy Hod, Ana Sofia Cerdeira, and S. Ananth Karumanchi Effects of Maternal Obesity on Fetal Programming: Molecular Approaches Caterina Neri and Andrea G. Edlow PRENATAL MOLECULAR SCREENING AND DIAGNOSIS Noninvasive Prenatal Screening for Genetic Diseases Using Massively Parallel Sequencing of Maternal Plasma DNA Lyn S. Chitty and Y.M. Dennis Lo Noninvasive Antenatal Determination of Fetal Blood Group Using Next-Generation Sequencing Klaus Rieneck, Frederik Banch Clausen, and Morten Hanefeld Dziegiel Genome-Wide Sequencing for Prenatal Detection of Fetal Single-Gene Disorders Ignatia B. Van den Veyver and Christine M. Eng The Amniotic Fluid Transcriptome as a Guide to Understanding Fetal Disease Lillian M. Zwemer and Diana W. Bianchi MOLECULAR APPROACHES TO DIAGNOSIS OF DISEASE IN THE NEONATE Potential Uses and Inherent Challenges of Using Genome-Scale Sequencing to Augment Current Newborn Screening Jonathan S. Berg and Cynthia M. Powell Whole-Exome Sequencing and Whole-Genome Sequencing in Critically III Neonates Suspected to Have Single-Gene Disorders Laurie D. Smith, Laurel K. Willig, and Stephen F. Kingsmore The Neonatal Salivary Transcriptome Jill L. Maron Index

Molecular Approaches to Reproductive and Newborn Medicine

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