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The Hepatitis B and Delta Viruses

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseImmunology and VaccinesViruses

Edited by Christoph Seeger, PhD, Fox Chase Cancer Center; Stephen A. Locarnini, Victorian Infectious Diseases Reference Laboratory (VIDRL)

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Preface and Contents
Chapter 1: Viral Hepatitis: Past and Future of Hepatitis B Virus and Hepatitis D Virus

© 2015 • 363 pages, illustrated (51 color, 15 B&W), index
Hardcover •
ISBN  978-1-621820-88-8

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  •     Description    
  •     Contents    


Despite the availability of an effective vaccine for hepatitis B, hundreds of millions of people worldwide are infected with the hepatitis B virus (HBV). This virus can cause serious liver damage and cancer in chronically infected patients. Hepatitis delta virus (HDV), a satellite of HBV, can exacerbate the disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of HBV and HDV infections and their management. Contributors discuss the HBV and HDV life cycles, their unique characteristics (e.g., the formation of HBV cccDNA), the immune responses they elicit, and the challenges they present to the development of antiviral treatments. The molecular mechanisms that lead to liver cirrhosis and hepatocellular carcinoma are reviewed, as are factors that influence the severity of the disease. Conventional treatments (e.g., interferons), emerging therapeutic strategies, and ongoing efforts to find a cure for chronic infections are also described.

This volume includes perspectives on the origins and evolution of these viruses, historical milestones in HBV and HDV research, and insights from animal models (e.g., woodchucks). It is an essential reference for all virologists, clinical and laboratory investigators, and physicians interested in reducing the burden of liver disease caused by HBV and HDV.


Viral Hepatitis: Past and Future of Hepatitis B Virus and Hepatitis D Virus
Emmanuel Thomas, Masato Yoneda, and Eugene R. Schiff
Viral Hepatitis B: Clinical and Epidemiological Characteristics
Gregory S. Burns and Alexander J. Thompson
Animal Models and the Molecular Biology of Hepadnavirus Infection
William S. Mason
Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus
Margaret Littlejohn, Stephen Locarnini, and Lilly Yuen
Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism
Koichi Watashi and Takaji Wakita
Hepadnavirus Genome Replication and Persistence
Jianming Hu and Christoph Seeger
ssembly and Release of Hepatitis B Virus
Lisa Selzer and Adam Zlotnick
Hepatitis B Virus X and Regulation of Viral Gene Expression
Betty L. Slagle and Michael J. Bouchard
Hepatitis B Virus Epidemiology
Jennifer H. MacLachlan and Benjamin C. Cowie
Immune Response in Hepatitis B Virus Infection
Anthony Tan, Sarene Koh, and Antonio Bertoletti
Hepatitis B Virus Genotypes and Variants
Chih-Lin Lin and Jia-Horng Kao
Hepatocellular Carcinoma
Marie-Annick Buendia and Christine Neuveut
The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection
Michael Roggendorf, Anna D. Kosinska, Jia Liu, and Mengji Lu
The Chimpanzee Model for Hepatitis B Virus Infection
Stefan F. Wieland
Mouse Models of Hepatitis B Virus Pathogenesis
Matteo Iannacone and Luca G. Guidotti
Prevention of Hepatitis B
Mei-Hwei Chang and Ding-Shinn Chen
Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B
Fabien Zoulim and David Durantel
Management of Chronic Hepatitis B in Patients from Special Populations
Ching-Lung Lai and Man-Fung Yuen
Treatment of Liver Cancer
Chun-Yu Liu, Kuen-Feng Chen, and Pei-Jer Chen
Hepatitis D Virus: Introduction and Epidemiology
Mario Rizzetto
Hepatitis D Virus Replication
John M. Taylor
Hepatitis D Virus Coinfection and Superinfection
Francesco Negro
Therapy of Delta Hepatitis
Cihan Yurdaydin and Ramazan Idilman