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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2020 • ISSN 0890-9369; Volume 34 includes full online access
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January - December 2020, 24 semimonthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetics Society.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2020 • ISSN: 1088-9051; Volume 30 includes full online access
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January - December 2020, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2020 • ISSN 1549-5485; Volume 27; includes full online access
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January - December 2020, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 2157-1422; Volume 10 includes full online access
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January - December 2020, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 1943-0264; Volume 12 includes full online access
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January - December 2020, 12 monthly issues
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A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal's website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library's HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 1559-6095; Volume 15; includes full online access
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January - December 2020, 12 monthly issues
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Description

  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

Read within Top Institutions and Companies Such as:

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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2020 • ISSN 1355-8382; Volume 26; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2020, 12 monthly issues
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Description

RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Cell Survival and Cell Death, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Kim Newton, Genentech; James M. Murphy, Walter and Eliza Hall Institute of Medical Research; Edward A. Miao, University of North Carolina at Chapel Hill

Due March 2020 • 300 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621823-55-1
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Description

In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components.

Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs.

Contents

Preliminary
BAX, BAK, and BOK; A Coming of Age for the BCL-2 Family Effector Proteins
Tudor Moldoveanu and Peter E. Czabotar
BH3 Mimetics: Targeting Pro-Survival Bcl2 Family Members for the Treatment of Cancer
David Huang and Wayne Fairbrother
Mechanisms of Caspase Activation
Marion Macfarlane
Cracking the Cell Death Code
Carla V. Rothlin and Sourav Ghosh
Phagocyte responses to cell death in flies
Andrew J. Davidson and Will Wood
Multi-tasking Kinase RIPK1 Regulates Cell Death and Inflammation
Kim Newton
The Killer Pseudokinase MLKL
James M. Murphy
Targeting Death Receptors in Cancer and Inflammation
Henning Walczak
Recent Insights on Inflammasomes, Gasderin Pores, and Pyroptosis
Xia, Louis Robert Hollingsworth IV, and Hao Wu
A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity
Arne Martens and Geert van Loo
Regulation of Cell Death and Immunity by XIAP
Philipp J. Jost and Domagoj Vucic
Cell Death and Neurodegeneration
Benjamin J. Andreone, Martin Larhammar, and Joseph W. Lewcock
Evolution of the Cell Death Machinery
Kay Hofmann
Programmed Cell Death in the Evolutionary Race Against Bacterial Virulence Factors
Carolyn A. Lacey and Edward A. Miao
How Viral Pathogens Subvert the Cell Death Machinery
Bill Kaiser
Cell Cycle Crosstalk with Caspases and Their Substrates
Patrick Connolly, Irmina García-Carpio, and Andreas Villunger
The Hypersensitive Response Cell Death in Plant Immunity
Eugenia Pitsii, Ujjal J. Phukan, and Núria S. Coll
Dysregulation of Cell Death in Chronic Human Inflammation
Yue Li, Christoph Klein, and Daniel Kotlarz
Neutrophil Extracellular Traps in Host Defense
Sabrina Sofia Burgener and Kate Schroder
Index
   

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Heart Development and Disease


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyHuman Biology and Disease

Edited by Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco; Paul R. Riley, University of Oxford

Due April 2020 • 250 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621823-58-2
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Description

During embryonic development, amorphous cardiac precursor cells are organized into a rhythmically contracting, multi-chambered muscular structure, complete with valves, vessels, and a conduction system. This structure—the heart—is the first organ to form in vertebrate embryos, and all subsequent life processes depend on its proper function. But a range of genetic and environmental factors can disrupt proper heart development and lead to congenital heart disease, the most common birth defect.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology describes recent progress in our understanding of early heart development and the various cell lineages involved, as well as mechanisms and models of congenital heart disease. The contributors discuss early cardiac morphogenesis and anatomy, the origins of contractile activity, the control of cardiac growth and size, and the signaling pathways and transcription programs that underpin these processes. Specific chapters are devoted to various muscle and non-muscle cell lineages involved in heart development, including those of the neural crest, endo- and epicardium, fibroblasts, coronary vessels, and cardiac conduction and lymphatic systems. Insights from chickens, frogs, and reptiles—model organisms that support research in this area—are also covered.

In addition, the authors examine congenital heart disease, genetic variants and environmental risk factors (e.g., teratogens and nutritional deficiencies) that disrupt normal heart development and cause various malformations, and the use of cell and animal model systems to study disease pathogenesis and test therapeutic interventions. This volume is therefore a valuable reference for all cell and developmental biologists, geneticists, and cardiologists who are interested in the early development and abnormalities of this complex, vital organ.

Contents

Preliminary
HEART DEVELOPMENT: GENERAL
Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles
Benjamin Swedlund and Fabienne Lescroart
The onset of cardiac function
Shankar Srinivas
Early cardiac morphogenesis
Vincent Christoffels
Anatomy of a Developing Heart
Tim Mohun
Determinants of Cardiac Growth and Size
Todd R. Heallen, Zachary A. Kadow, Jun Wang, and James F. Martin
Genetic and Epigenetic Control of Heart Development
Brynn N. Akererg and William T. Pu
Long Noncoding RNAs in Cardiac Development
Michael Alexanian and Samir Ounzain
Genome-wide approaches for understanding heart development
Laurie Boyer
SPECIFIC CELL TYPES-LINEAGES
Coronary vessel development
Bin Zhou
Formation and Growth of Cardiac Lymphatics During Embryonic Development, Heart Regeneration, and Disease
Dana Gancz, Gal Perlmoter and Karina Yaniv
Development of the Cardiac Conduction System
Samadrita Bhattacharyya and Nikhil V. Munshi
Developmental Pathway of Cardiac Fibroblasts
Michelle D. Tallquist
Cardiac neural crest
Hiroyuki Yamigishi
Epicardium in Heart Development
Yingxi Cao, Sierra Duca, and Jingli Cao
Heart Disease and Development: The Endocardium and Heart Valves
Bailey Dye and Joy Lincoln
MODEL ORGANISMS
Zebrafish
Daniela Panakova
Frog
Frank Conlon
Chicken
Andrea Munsterberg
Reptiles as a Model System to Study Heart Development
Bjarke Jensen and Vincent M. Christoffels
CONGENITAL HEART DISEASE
Genetic Basis of Human Congenital Heart Disease
Shannon N. Nees and Wendy K. Chung
In Vivo and In Vitro Genetic Models of Congenital Heart Disease
Uddalak Majumdar, Jun Yasuhara and Vidu Garg
Environmental Risk Factors for Congenital Heart Disease
Jacinta Isabelle Kalisch-Smith, Nikita Ved, and Duncan Burnaby Sparrow
Index
   

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Hepatitis C Viruses: The Story of a Scientific and Therapeutic Revolution


Subject Area(s):  Infectious DiseasesHuman Biology and DiseaseDiseasesViruses

Edited by Arash Grakoui, Emory University; Jean-Michel Pawlotsky, Hopital Henri Mondor / Universite Paris Est; Glenn Randall, University of Chicago

Due May 2020 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-19-3
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  •     Contents    

Description

Hepatitis C infects 71 million people worldwide and there is currently no vaccine against the virus that causes the disease (HCV). This volume describes recent advances in our understanding of the biology of HCV and the consequences of infection, as well as ongoing efforts to develop a vaccine and new treatment strategies.

Contents

Preliminary
1. HCV: 30 years since its identification
Michael Houghton
2. HCV genetic heterogeneity
Jens Bukh
3. HCV Structure
Joseph Marcotrigiano and Maria Theresa Catanese
4. Cell Culture Systems of HCV Using JFH-1 and Other Strains
Takaji Wakita
5. Animal Models of Hepatitis C Virus Infection
Alexander Ploss and Amit Kapoor
6. Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion
Gisa Gerold, Rebecca Moeller, and Thomas Pietschmann
7. HCV Replication
Ralf Bartenschlager, Keisuke Tabata, and Christopher Neufeldt
8. HCV Assembly and Egress Via Modifications in Host Lipid Metabolic Systems
Kunitada Shimotohno
9. HCV-host interactions in cellular pathogenesis
Qisheng Li and Jake Liang
10. Cellular innate immune control of HCV infection
Michael Gale and Ram Savan
11. Control of HCV infection by NK cells and macrophages
Hugo Rosen & Lucy Golden-Mason
12. T cell control of HCV infection
Chris Walker
13. Role of antibodies in HCV infection
Mansun Law
14. Interferon-free HCV therapy
Jean-Michel Pawlotsky
15. Heptatis C Virus Epidemiology and the Impact of Interferon-free HCV Therapy
Jeffrey V. Lazarus, Elena Roel, and Ahmed M. Elsharkawy
16. Natural History of Hepatic and Extrahepatic HCV Diseases and Impact of Interferon-Free HCV Therapy
Francesco Negro
17. Elimination of hepatitis C as a public health threat
Sophia Schroeder, Alisa Pedrana, Joseph Doyle, Campbell Aitken, and Margaret Hellard
18. Pros and cons of an HCV vaccine
Andrea Cox
19. Future Perspectives
Jean-Michel Pawlotsky, Arash Grakoui, and Glenn Randall
Index
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