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Subject Area(s):  Cognition and BehaviorNeurobiology

Edited by R. Christopher Pierce, University of Pennsylvania; Paul J. Kenny, The Scripps Research Institute

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© 2013 • 368 pp., illus (30 4C and 25 B&W), index
Hardcover • $135 67.50
ISBN  978-1-936113-47-7
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  •     Description    
  •     Contents    


Drug and alcohol abuse elicits significant biological changes in the brain that drive compulsive behavior and lead to addiction. Abrupt cessation leads to withdrawal, craving, and relapse. A complete understanding of the brain changes produced by abused substances is therefore necessary if we are to develop treatments for drug dependence.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine explores the biological basis of addiction to alcohol, nicotine, and other psychoactive drugs. Contributors describe the molecular targets of these drugs, the resulting changes to neural networks, and the various genetic, developmental, and behavioral factors that influence the progression from abuse to addiction. Animal models of addictive behavior and techniques to dissect neural circuits are also described.

This volume includes discussion of compounds currently used or under development to treat drug dependence. Thus, it is an indispensable reference for neuroscientists and all who are interested in reducing the public health burden of substance abuse.


Rational Development of Addiction Pharmacotherapies: Successes, Failures, and Prospects
R. Christopher Pierce, Charles P. O’Brien, Paul J. Kenny, and Louk J.M.J. Vanderschuren
Animal Studies of Addictive Behavior
Louk J.M.J. Vanderschuren and Serge H. Ahmed
Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal Model
David Belin and Véronique Deroche-Gamonet
Systems Level Neuroplasticity in Drug Addiction
Matthew W. Feltenstein and Ronald E. See
Optogenetic Strategies to Dissect the Neural Circuits that Underlie Reward and Addiction
Alice M. Stamatakis and Garret D. Stuber
Mechanisms of Psychostimulant-Induced Structural Plasticity
Sam A. Golden and Scott J. Russo
Roles of Nucleus Accumbens CREB and Dynorphin in Dysregulation of Motivation
John W. Muschamp and William A. Carlezon, Jr.
Cocaine-Evoked Synaptic Plasticity of Excitatory Transmission in the
Ventral Tegmental Area
Christian Lüscher
Psychostimulant-Induced Neuroadaptations in Nucleus Accumbens
AMPA Receptor Transmission
R. Christopher Pierce and Marina E. Wolf
Epigenetics and Psychostimulant Addiction
Heath D. Schmidt, Jacqueline F. McGinty, Anne E. West, and Ghazaleh Sadri-Vakili
Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
Michelle S. Mazei-Robison and Eric J. Nestler
Glutamate Mechanisms Underlying Opiate Memories
Jamie Peters and Taco J. De Vries
The Neurobiology of Opiate Motivation
Ryan Ting-A-Kee and Derek van der Kooy
Medications Development for Opioid Abuse
S. Stevens Negus and Matthew L. Banks
Molecular Mechanisms Underlying Behaviors Related to Nicotine Addiction
Marina R. Picciotto and Paul J. Kenny
Short-and Long-Term Consequences of Nicotine Exposure during Adolescence
for Prefrontal Cortex Neuronal Network Function
Natalia A. Goriounova and Huibert D. Mansvelder
Mesolimbic Dopamine and Habenulo-Interpeduncular Pathways in Nicotine Withdrawal
John A. Dani and Mariella De Biasi
The “Stop” and “Go” of Nicotine Dependence: Role of GABA and Glutamate
Manoranjan S. D’Souza and Athina Markou
Translational Research in Nicotine Dependence
Jill R. Turner, Allison Gold, Robert Schnoll, and Julie A. Blendy
Ethanol Effects on N-Methyl-d-Aspartate Receptors in the Bed Nucleus
of the Stria Terminalis
Tiffany A. Wills and Danny G. Winder
The Central Amygdala and Alcohol: Role of γ-Aminobutyric Acid, Glutamate, and Neuropeptides
Marisa Roberto, Nicholas W. Gilpin, and George R. Siggins
Opioid Pharmacogenetics of Alcohol Addiction
Wade Berrettini
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking
Erik B. Oleson and Joseph F. Cheer
Synaptic Targets of Δ9-Tetrahydrocannabinol in the Central Nervous System
Alexander F. Hoffman and Carl R. Lupica