Angiogenesis: Biology and Pathology

Click to Enlarge				Angiogenesis: Biology and Pathology Subject Area(s): Developmental Biology; Cell Biology; Cancer Biology Edited by Michael Klagsbrun, Children's Hospital Boston; Patricia D'Amore, Schepens Eye Research Institute Download Free Excerpts from Angiogenesis: Biology and Pathology: Download Preface and Contents Download Index

				© 2011 • 522 pp., illus. (62 4C and 11 B&W), index Hardcover • ~~$135~~ 121.50 ISBN 978-1-936113-43-9 You save: 10%

Description Contents Description Angiogenesis is the process by which new blood vessels are generated from preexisting vessels. It is vital for proper embryonic development, patterning of the vascular system, and wound healing. It is rate limiting in cancer progression, because the formation of new blood vessels is essential for growth and survival of tumors. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered. This volume, which includes discussions of other vascular dysfunctions (e.g., arteriovenous malformations) and comparisons between the blood vascular system and the lymphatic system, is a vital reference for developmental and cancer biologists, as well as anyone seeking to understand the biology and pathology of the vascular system. Contents Preface ENDOTHELIAL CELLS, ANGIOGENESIS Endothelial Cell Heterogeneity William C. Aird Human Endothelial Progenitor Cells Mervin C. Yoder VEGF-Directed Blood Vessel Patterning: From Cells to Organisms Victoria L. Bautch VEGF and Notch in Tip and Stalk Cell Selection Raquel Blanco and Holger Gerhardt Tips, Stalks, Tubes: Notch-Mediated Cell Fate Determination and Mechanisms of Tubulogenesis during Angiogenesis Jennifer J. Tung, Ian W. Tattersall, and Jan Kitajewski Vascular Lumen Formation Eckhard Lammert and Jennifer Axnick miRNAs as Modulators of Angiogenesis Shira Landskroner-Eiger, Isabelle Moneke, and William C. Sessa LYMPHANGIOGENESIS Myeloid Cells and Lymphangiogenesis Adrian Zumsteg and Gerhard Christofori The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System Inho Choi, Sunju Lee, and Young-Kwon Hong VASCULAR DEVELOPMENT Vascular Development in the Zebraﬁsh Aniket V. Gore, Kathryn Monzo, Young R. Cha, Weijun Pan, and Brant M. Weinstein Molecular Parallels between Neural and Vascular Development Anne Eichmann and Jean-Léon Thomas ANGIOGENESIS STIMULATORS AND INHIBITORS Signal Transduction by Vascular Endothelial Growth Factor Receptors Sina Koch and Lena Claesson-Welsh Vascular Hyperpermeability, Angiogenesis, and Stroma Generation Janice A. Nagy, Ann M. Dvorak, and Harold F. Dvorak PIGF: A Multitasking Cytokine with Disease-Restricted Activity Mieke Dewerchin and Peter Carmeliet The Complex Role of Angiopoietin-2 in the Angiopoietin–Tie Signaling Pathway Gavin Thurston and Christopher Daly Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2 Patrick R. Lawler and Jack Lawler Semaphorins in Angiogenesis and Tumor Progression Gera Neufeld, Adi D. Sabag, Noa Rabinovicz, and Ofra Kessler VASCULAR PATHOLOGY Tumor Endothelial Cells Andrew C. Dudley Infantile Hemangioma—Mechanism(s) of Drug Action on a Vascular Tumor Shoshana Greenberger and Joyce Bischoff Endothelial Cell-to-Cell Junctions: Adhesion and Signaling in Physiology and Pathology Maria Grazia Lampugnani av Integrins in Angiogenesis and Cancer Sara M. Weis and David A. Cheresh Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease Shom Goel, Andus Hon-Kit Wong, and Rakesh K. Jain Antiangiogenic Therapy for Ischemic Retinopathies Motasem Al-Latayfeh, Paolo S. Silva, Jennifer K. Sun, and Lloyd Paul Aiello Angiogenic Factors in Preeclampsia and Related Disorders Ana Soﬁa Cerdeira and S. Ananth Karumanchi The Role of the Tumor Microenvironment in Regulating Angiogenesis Randolph S. Watnick Common Polymorphisms in Angiogenesis Michael S. Rogers and Robert J. D'Amato VASCULAR ANOMALIES Arteriovenous Malformations and Other Vascular Malformation Syndromes Kevin J. Whitehead, Matthew C.P. Smith, and Dean Y. Li Vascular Anomalies: From Genetics toward Models for Therapeutic Trials Melanie Uebelhoer, Laurence M. Boon, and Miikka Vikkula CLINICAL APPLICATIONS, EVALUATIONS Anti-VEGF Therapies in the Clinic Kellen L. Meadows and Herbert I. Hurwitz The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward Mark W. Kieran, Raghu Kalluri, and Yoon-Jae Cho Index

Angiogenesis: Biology and Pathology

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