Contents

Symposium Participants

Foreword

Introduction

Biological Rhythms Workshop I: Introduction to Chronobiology S.J. Kuhlman, S.R. Mackey, and J.F. Duffy

Biological Rhythms Workshop IA: Molecular Basis of Rhythms Generation

S.R. Mackey

Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function

S.J. Kuhlman

Biological Rhythms Workshop IC: Sleep and Rhythms

M.Y. Münch, S.W. Cain, and J.F. Duffy

Clockworks

A Cyanobacterial Circadian Clock Based on the Kai Oscillator

T. Kondo

A Circadian Clock in Neurospora: How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day

J.C. Dunlap, J.J. Loros, H.V. Colot, A. Mehra, W.J. Belden, M. Shi, C.I. Hong, L.F. Larrondo, C.L. Baker, C.-H. Chen, C. Schwerdtfeger, P.D. Collopy, J.J. Gamsby, and R. Lambreghts

A PER/TIM/DBT Interval Timer for Drosophila’s Circadian Clock

L. Saez, P. Meyer, and M.W. Young

Transcriptional Feedback and Definition of the Circadian Pacemaker in Drosophila and Animals

M. Rosbash, S. Bradley, S. Kadener, Y. Li, W. Luo, J.S. Menet, E. Nagoshi, K. Palm, R. Schoer,Y. Shang, and C.-H.A. Tang

Genetic and Molecular Analysis of the Central and Peripheral Circadian Clockwork of Mice

E.S. Maywood, J.S. O’Neill, A.B. Reddy, J.E. Chesham, H.M. Prosser, C.P. Kyriacou, S.I.H. Godinho, P.M. Nolan, and M.H. Hastings

The Multiple Facets of Per2

U. Albrecht, A. Bordon, I. Schmutz, and J. Ripperger

Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme

B. Grimaldi,Y. Nakahata, S. Sahar, M. Kaluzova, D. Gauthier, K. Prahm, N. Patel, J. Hirayama, and P. Sassone-Corsi

The Ancestral Circadian Clock of Monarch Butterflies: Role in Time-compensated Sun Compass Orientation

S.M. Reppert

Structure and Function of Animal Cryptochromes

N. Öztürk, S.-H. Song, S. Özgür, C.P. Selby, L. Morrison, C. Partch, D. Zhong, and A. Sancar

Structure Function Analysis of Mammalian Cryptochromes

F. Tamanini, I. Chaves, M.I. Bajek, and G.T.J. van der Horst

Posttranscriptional and Posttranslational Mechanisms

The Gonyaulax Clock at 50: Translational Control of Circadian Expression

J.W. Hastings

Posttranscriptional Regulation of Mammalian Circadian Clock Output

E. Garbarino-Pico and C.B. Green

Biological Clocks and the Coordination Theory of RNA Operons and Regulons

J.D. Keene

Role of Phosphorylation in the Mammalian Circadian Clock

K. Vanselow and A. Kramer

Posttranslational Regulation of Neurospora Circadian Clock by CK1a-dependent Phosphorylation

C. Querfurth, A. Diernfellner, F. Heise, L. Lauinger, A. Neiss, Ö. Tataroglu, M. Brunner,and T. Schafmeier

Posttranslational Control of the Neurospora Circadian Clock

J. Cha, G. Huang, J. Guo, and Y. Liu

Posttranslational Photomodulation of Circadian Amplitude

D.E. Somers, S. Fujiwara, W.-Y. Kim, and S.-S. Suh

Circadian Output, Input, and Intracellular Oscillators: Insights into the Circadian Systems of Single Cells

J.J. Loros, J.C. Dunlap, L.F. Larrondo, M. Shi, W.J. Belden, V.D. Gooch, C.-H. Chen, C.L. Baker, A. Mehra, H.V. Colot, C. Schwerdtfeger, R. Lambreghts, P.D. Collopy, J.J. Gamsby, and C.I. Hong

Principles and Problems Revolving Round Rhythm-related Genetic Variants

J.C. Hall, D.C. Chang, and E. Dolezelova

Synchronization of the Drosophila Circadian Clock by Temperature Cycles

F.T. Glaser and R. Stanewsky

What Is There Left to Learn about the Drosophila Clock?

J. Blau, F. Blanchard, B. Collins, D. Dahdal, A. Knowles, D. Mizrak, and M. Ruben

Genetics and Neurobiology of Circadian Clocks in Mammals

S.M. Siepka, S.-H. Yoo, J. Park, C. Lee, and J.S. Takahashi

The Biology of the Circadian Ck1ε tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species

A.S.I. Loudon, Q.J. Meng, E.S. Maywood, D.A. Bechtold, R.P. Boot-Handford, and M.H. Hastings

Novel Insights from Genetic and Molecular Characterization of the Human Clock

L.J. Ptâček, C.R. Jones, and Y.-H. Fu

Entrainment and Peripheral Clocks

Circadian Entrainment of Neurospora crassa

M. Merrow and T. Roenneberg

Constant Darkness Is a Mammalian Biological Signal

C.C. Lee

Entrainment of the Human Circadian Clock

T. Roenneberg and M. Merrow

Peripheral Clocks: Keeping Up with the Master Clock

E. Kowalska and S.A. Brown

Physiological Importance of a Circadian Clock Outside the Suprachiasmatic Nucleus

K.-F. Storch, C. Paz, J. Signorovitch, E. Raviola, B. Pawlyk, T. Li, and C.J. Weitz

Regulation of Circadian Gene Expression in Liver by Systemic Signals and Hepatocyte Oscillators

B. Kornmann, O. Schaad, H. Reinke, C. Saini, and U. Schibler

Systems Approaches to Biological Clocks

Integrating the Circadian Oscillator into the Life of the Cyanobacterial Cell

S.S. Golden

The Yeast Metabolic Cycle: Insights into the Life of a Eukaryotic Cell

B.P. Tu and S.L. McKnight

Complexity of the Neurospora crassa Circadian Clock System: Multiple Loops and Oscillators

R.M. de Paula, M.W. Vitalini, R.H. Gomer, and D. Bell-Pedersen

The Diurnal Project: Diurnal and Circadian Expression Profiling, Model-based Pattern Matching, and Promoter Analysis

T.C. Mockler, T.P. Michael, H.D. Priest, R. Shen, C.M. Sullivan, S.A. Givan, C. McEntee, S.A. Kay, and J. Chory

Systems Biology of Mammalian Circadian Clocks

H.R. Ueda

High-resolution Time Course Analysis of Gene Expression from Pituitary

M. Hughes, L. DeHaro, S.R. Pullivarthy, J. Gu, K. Hayes, S. Panda, and J. Hogenesch

Nuclear Receptors, Metabolism, and the Circadian Clock

X. Yang, K.A. Lamia, and R.M. Evans

Models

Bacterial Circadian Programs

C.H. Johnson

Stochastic Phase Oscillators and Circadian Bioluminescence Recordings

J. Rougemont and F. Naef

Reversible Protein Phosphorylation Regulates Circadian Rhythms

D.M. Virshup, E.J. Eide, D.B. Forger, M. Gallego, and E. Vielhaber Harnish

Evolution of the Clock from Yeast to Man by Period Doubling Folds in the Cellular Oscillator

R.R. Klevecz and C.M. Li

Development, Proliferation, and Aging

Intracellular Developmental Timers

M. Raff

Transcriptional Feedback Loop Regulation, Function, and Ontogeny in Drosophila

J. Benito, H. Zheng, F.S. Ng, and P.E. Hardin

Building the Spine: The Vertebrate Segmentation Clock

O. Pourquié

Ultradian Oscillators in Somite Segmentation and Other Biological Events

R. Kageyama, S. Yoshiura, Y. Masamizu, and Y. Niwa

The Role of Circadian Regulation in Cancer

S. Gery and H.P. Koeffler

Cross-talks between Circadian Timing System and Cell Division Cycle Determine Cancer Biology and Therapeutics

F. Lévi, E. Filipski, I. Iurisci, X.M. Li, and P. Innominato

The Clock Proteins, Aging, and Tumorigenesis

R.V. Kondratov and M.P. Antoch

Sirtuins in Aging and Disease

L. Guarente

Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-sensitive Strains

A.V. Samuelson, R.R. Klimczak, D.B. Thompson, C.E. Carr, and G. Ruvkun

Neuroanatomy and Circuits

Circadian Photoreception in Vertebrates

S. Doyle and M. Menaker

Multiple Photoreceptors Contribute to Nonimage-forming Visual Functions Predominantly through Melanopsin-containing Retinal Ganglion Cells

A.D. Güler, C.M. Altimus, J.L. Ecker, and S. Hattar

The Lateral and Dorsal Neurons of Drosophila melanogaster: New Insights about Their Morphology and Function

C. Helfrich-Förster, T. Yoshii, C. Wülbeck, E. Grieshaber, D. Rieger, W. Bachleitner, P. Cusumano, and F. Rouyer

Exploring Spatiotemporal Organization of SCN Circuits

L. Yan, I. Karatsoreos, J. LeSauter, D.K. Welsh, S. Kay, D. Foley, and R. Silver

Inducible Clocks: Living in an Unpredictable World

C.B. Saper and P.M. Fuller

Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian System

H. Okamura

Sleep, Seasons, and Mood

Molecular Analysis of Sleep:Wake Cycles in Drosophila

A. Sehgal, W. Joiner, A. Crocker, K. Koh, S. Sathyanarayanan, Y. Fang, M. Wu, J.A. Williams, and X. Zheng

Neurohormonal and Neuromodulatory Control of Sleep in Drosophila?

K. Foltenyi, R. Andretic, J.W. Newport, and R.J. Greenspan

Molecular Analysis of Sleep

M. Tafti and P. Franken

Sleep and Circadian Rhythms in Humans

C.A. Czeisler and J.J. Gooley

Thermosensitive Splicing of a Clock Gene and Seasonal Adaptation

W.-F. Chen, K.H. Low, C. Lim, and I. Edery

Endogenous Circannual Clock and HP Complex in a Hibernation Control System

N. Kondo

On the Chronobiology of Cohabitation

M.J. Paul and W.J. Schwartz

Melatonin and Human Chronobiology

A.J. Lewy

A Role for the Clock Gene in Bipolar Disorder

C.A. McClung

The Possible Interplay of Synaptic and Clock Genes in Autism Spectrum Disorders

T. Bourgeron

Summary. Circadian Clocks: 50 Years On

M. Menaker

Author Index

Subject Index

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