Human Fungal Pathogens

Click to Enlarge				Human Fungal Pathogens Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Human Biology and Disease; Microbiology Edited by Arturo Casadevall, Albert Einstein College of Medicine of Yeshiva University; Aaron P. Mitchell, Carnegie Mellon University; Judith Berman, Tel Aviv University; Kyung J. Kwon-Chung, National Institute of Allergy and Infectious Diseases; John R. Perfect, Duke University Mycology Research Unit; Joseph Heitman, Duke University Medical Center Download Free Excerpts from Human Fungal Pathogens: Preface and Contents The Spectrum of Fungi That Infects Humans Index

				© 2015 • 577 pages, illustrated (46 color, 17 B&W), index Hardcover • ~~$135~~ 121.50 ISBN 978-1-621820-75-8 You save: 10%

Description Contents Description Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete’s foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans—their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored. This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens. Contents Preface INTRODUCTION AND GENERAL PRINCIPLES AND EVOLUTION OF FUNGAL PATHOGENS The Spectrum of Fungi That Infects Humans Julia R. Köhler, Arturo Casadevall, and John Perfect Evolutionary Perspectives on Human Fungal Pathogens John W. Taylor Sexual Reproduction of Human Fungal Pathogens Joseph Heitman, Dee A. Carter, Paul S. Dyer, and David R. Soll Functional Profiling of Human Fungal Pathogen Genomes Alexi I. Goranov and Hiten D. Madhani Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity Richard J. Bennett, Anja Forche, and Judith Berman HOST IMMUNITY AND FUNGAL INFECTION Adaptive Immunity to Fungi Akash Verma, Marcel Wüthrich, George Deepe, and Bruce Klein Innate Defense against Fungal Pathogens Rebecca A. Drummond, Sarah L. Gaffen, Amy G. Hise, and Gordon D. Brown Mendelian Genetics of Human Susceptibility to Fungal Infection Michail S. Lionakis, Mihai G. Netea, and Steven M. Holland MICROBIAL VIRULENCE MECHANISMS Fungal Biofilms, Drug Resistance, and Recurrent Infection Jigar V. Desai, Aaron P. Mitchell, and David R. Andes Fungal Pathogens: Survival and Replication within Macrophages Andrew S. Gilbert, Robert T. Wheeler, and Robin C. May Fungal Morphogenesis Xiaorong Lin, J. Andrew Alspaugh, Haoping Liu, and Steven Harris Host Cell Invasion by Medically Important Fungi Donald C. Sheppard and Scott G. Filler Metabolism in Fungal Pathogenesis Iuliana V. Ene, Sascha Brunke, Alistair J.P. Brown, and Bernhard Hube TREATMENT STRATEGIES Fungal Diagnostics Thomas R. Kozel and Brian Wickes Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches Terry Roemer and Damian J. Krysan Fungal Vaccines and Immunotherapeutics Evelyn Santos and Stuart M. Levitz Antifungal Pharmacokinetics and Pharmacodynamics Alexander J. Lepak and David R. Andes Treatment Principles for the Management of Mold Infections Dimitrios P. Kontoyiannis and Russell E. Lewis Treatment Principles for Candida and Cryptococcus Laura C. Whitney and Tihana Bicanic Antifungal Clinical Trials and Guidelines: What We Know and Do Not Know Peter G. Pappas Mechanisms of Antifungal Drug Resistance Leah E. Cowen, Dominique Sanglard, Susan J. Howard, P. David Rogers, and David S. Perlin FUNGAL PATHOGENS Cryptococcus neoformans and Cryptococcus gattii,, the Etiologic Agents of Cryptococcosis Kyung J. Kwon-Chung, James A. Fraser, Tamara L. Doering, Zhuo Wang, Guilhem Janbon, Alexander Idnurm, and Yong-Sun Bahn The Candida Pathogenic Species Complex Siobhán A. Turner and Geraldine Butler Aspergillus fumigatus and Related Species Janyce A. Sugui, Kyung J. Kwon-Chung, Praveen Juvvadi, Jean-Paul Latgé, and William J. Steinbach Thermally Dimorphic Human Fungal Pathogens—Polyphyletic Pathogens with a Convergent Pathogenicity Trait Anita Sil and Alex Andrianopoulos Fungi on the Skin: Dermatophytes and Malassezia Theodore C. White, Keisha Findley, Thomas L. Dawson, Jr., Annika Scheynius, Teun Boekhout, Christina A. Cuomo, Jun Xu, and Charles W. Saunders Human Fungal Pathogens of Mucorales and Entomophthorales Leonel Mendoza, Raquel Vilela, Kerstin Voelz, Ashraf S. Ibrahim, Kerstin Voigt, and Soo Chan Lee Black Molds and Melanized Yeasts Pathogenic to Humans Anuradha Chowdhary, John Perfect, and G. Sybren de Hoog Pneumocystis Francis Gigliotti, Andrew H. Limper, and Terry Wright The Human Mycobiome Patrick C. Seed Index

Human Fungal Pathogens

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