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The Nucleus, Second Edition

Subject Area(s):  Cell BiologyMolecular BiologyBiochemistry

Edited by Ana Pombo, Max Delbrück Center for Molecular Medicine; Martin W. Hetzer, Salk Institute for Biological Studies; Tom Misteli, National Cancer Institute, NIH

Due October 2021 • 300 pages (approx.), illustrated (75 color), index
Hardcover • $135
ISBN  978-1-621823-89-6

  •     Description    
  •     Contents    


The nucleus of the cell is the control center that contains its DNA. This volume explores how the nucleus is organized, examining how different subcompartments form and interact and the role these play in gene regulation and processes such as splicing of RNA.


1. The Nuclear Lamina
Xianrong Wong, Ashley J. Melendez-Perez, and Karen L. Reddy
2. Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome
Marcela Raices and Maximiliano A. D’Angelo
3. The Nuclear Pore Complex as a Transcription Regulator
Michael Chas Sumner and Jason Brickner
4. The Diverse Cellular Functions of Inner Nuclear Membrane Proteins
Sumit Pawar and Ulrike Kutay
5. Mechanical Forces in Nuclear Organization
Yekaterina A. Miroshnikova and Sara. A. Wickström
6. Liquid-Liquid Phase Separation in Chromatin
Karsten Rippe
7. The Stochastic Genome and Its Role in Gene Expression
Christopher H. Bohrer and Daniel R. Larson
8. Emerging properties and functions of actin and actin filaments inside the nucleus
Svenja Ulferts, Bina Prajapati, Robert Grosse, and Maria K. Vartiainen
9. Physical Nature of Chromatin in the Nucleus
Kazuhiro Maeshima, Shiori Iida, and Sachiko Tamura
10. Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions
Leonid Mirny and Job Dekker
11. Uncovering the Principles of Genome Folding by 3D Chromatin Modeling
Asli Yildirim, Lorenzo Boninsegna, Yuxiang Zhan, and Frank Alber
12. Transcription Factor Dynamics
Feiyue Lu and Timothée Lionnet
13. Essential Roles for RNA in Shaping Nuclear Organization
Sofia A. Quinodoz and Mitchell Guttman
14. Nuclear Compartments: An Incomplete Primer To Nuclear Compartments, Bodies, And Genome Organization Relative To Nuclear Architecture
Andrew S. Belmont
15. The Impact of Space and Time on the Functional Output of the Nucleus
Marcelo Nollmann, Isma Bennabi, Markus Götz, and Thomas Gregor
16. Mammalian DNA Replication Timing
Athanasios E. Vouzas and David M. Gilbert
17. Imaging Organization of RNA Processing Within the Nucleus
Jeetayu Biswas, Weihan Li, Robert H. Singer, and Robert A. Coleman
18. Chromatin Mechanisms Driving Cancer
Berkley Gryder, Pete Scacheri, Thomas Ried, and Javed Khan
19. Viruses in the Nucleus
Bojana Lucic, Ines J. de Castro, and Marina Lusic
20. 3D or Not 3D: Shaping the Genome During Development
Juliane Glaser and Stefan Mundlos
21. Epigenetic Reprogramming in Early Animal Development
Zhenhai Du, Ke Zhang, and Wei Xie
22. The Molecular and Nuclear Dynamics of X-Chromosome Inactivation
François Dossin and Edith Heard
23. Organization of the Pluripotent Genome
Patrick S.L. Lim and Eran Meshorer