Contents

Preliminary

Introduction

Ross Levine, Ari Melnick, and Michael Kharas

Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration

Oakley C. Olson, Yoon-A Kang, an Emmanuelle Passegué

Epidemiology and Etiology of Leukemia and Lymphoma

Jordan A. Baeker Bispo, Paulo S. Pinheiro, and Erin K. Kobetz

Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas

Nathanael G. Bailey and Kojo S. Elenitoba-Johnson

Clonal Hematopoiesis and premalignant diseases

Duane Hassane

Cancer Stem Cells

Liran Shlush and Tzah Feldman

Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons From Current Approaches and Advances in the LSC Model Can Inform Better Strategies for Treating AML

Kelly Mitchell and Ulrich Steidl

Pediatric Leukemias and lymphomas

Scott Armstrong

Epigenetics of Leukemia and Lymphomas

Ari Melnick

RNA Regulators in Leukemia and Lymphoma

Michael Kharas

Metabolism of Leukemia and Lymphoma

Andrew Intlekofer

Mouse Models of Myeloid Malignancies

George Vassiliou and Faisal Basheer

Mouse Modeling of Lymphomas

Laura Pasqualucci and Ulf Klein

Modeling Leukemia with Human-Induced Pluripotent Stem Cells

Eirini P. Papapetrou

The Molecular Genetics of Myeloproliferative Neoplasms

Anna E. Marneth an Ann Mullally

Acute Myeloid Leukemia

Ross Levine

Acute Megakaryocytic Leukemia

Maureen McNulty and John D. Crispino

The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Francesca Gianni, Laura Belver, and Adolfo Ferrando

The Biology of B-Progenitor Acute Lymphoblastic Leukemia

Kathryn G. Roberts and Charles G. Mullighan

Chronic Lymphocytic Leukemia

Nicholas Chiorazzi, Shih-Shih Chen, and Kanti R. Rai

Hairy Cell Leukemia and Histiocytic Diseases

Omar Abdel Wahab

Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells

Jennifer Shingleton, Jie Wang, Carolyn Baloh, Tushar Dave, Nicholas Davis, Lanie Happ, Othmane Jadi, Rachel Kositsky, Xiang Li, Cassandra Love, Razvan Panea, Qiu Qin, Anupama Reddy, Naina Singhi, Eileen Smith, Devang Thakkar, and Sandeep S. Dave

Mature T-Cell Lymphomas and NK

Teresa Palomero

Plasma Cell Neoplasms

Constantine Mitsiades

Immunotherapy

Renier Brentjens

Future of New Treatment Paradigms

Ross Levine, Ari Melnick, and Michael Kharas

Index