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Leukemia and Lymphoma: Molecular and Therapeutic Insights

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseCancer Biology

Edited by Michael G. Kharas, Memorial Sloan Kettering Cancer Center; Ross L. Levine, Memorial Sloan Kettering Cancer Center; Ari M. Melnick, Weill Cornell Medicine

Download a Free Excerpt from Leukemia and Lymphoma: Molecular & Therapeutic Insights:

The Biology of B-Progenitor Acute Lymphoblastic Leukemia

© 2020 • 520 pages, illustrated (64 color), index
Hardcover •
ISBN  978-1-621821-42-7

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  •     Description    
  •     Contents    
  •     Reviews    


Leukemia and lymphoma are cancers that affect white blood cells. There are several different types, each with different causes, symptoms, treatments, and survival rates. Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. The contributors review the normal functions of hematopoietic stem cells—the precursors to white blood cells—and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g., MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma.

In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. This volume is therefore a vital reference for all cancer biologists and clinician—scientists concerned with defeating these diseases.


Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration
Oakley C. Olson, Yoon-A Kang, and Emmanuelle Passegué
Epidemiology and Etiology of Leukemia and Lymphoma
Jordan A. Baeker Bispo, Paulo S. Pinheiro, and Erin K. Kobetz
Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas
Nathanael G. Bailey and Kojo S.J. Elenitoba-Johnson
Clonal Hematopoiesis and Premalignant Diseases
Justin Kaner, Pinkal Desai, Nuria Mencia-Trinchant, Monica L. Guzman, Gail J. Roboz, and Duane C. Hassane
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)
Kelly Mitchell and Ulrich Steidl
Epigenetic Mechanisms in Leukemias and Lymphomas
Cihangir Duy, Wendy Béguelin, and Ari Melnick
RNA Regulators in Leukemia and Lymphoma
Camila Prieto and Michael G. Kharas
Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma
Maximilian Stahl, Zachary D. Epstein-Peterson, and Andrew M. Intlekofer
Mouse Models of Myeloid Malignancies
Faisal Basheer and George Vassiliou
Mouse Models in the Study of Mature B-Cell Malignancies
Laura Pasqualucci and Ulf Klein
Modeling Leukemia with Human Induced Pluripotent Stem Cells
Eirini P. Papapetrou
The Molecular Genetics of Myeloproliferative Neoplasms
Anna E. Marneth and Ann Mullally
The Role of Somatic Mutations in Acute Myeloid Leukemia Pathogenesis
Ashwin Kishtagari and Ross L. Levine
Acute Megakaryocytic Leukemia
Maureen McNulty and John D. Crispino
The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia
Francesca Gianni, Laura Belver, and Adolfo Ferrando
The Biology of B-Progenitor Acute Lymphoblastic Leukemia
Kathryn G. Roberts and Charles G. Mullighan
Chronic Lymphocytic Leukemia
Nicholas Chiorazzi, Shih-Shih Chen, and Kanti R. Rai
MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age
Rikhia Chakraborty, Omar Abdel-Wahab, and Benjamin H. Durham
Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells
Jennifer Shingleton, Jie Wang, Carolyn Baloh, Tushar Dave, Nicholas Davis, Lanie Happ, Othmane Jadi, Rachel Kositsky, Xiang Li, Cassandra Love, Razvan Panea, Qiu Qin, Anupama Reddy, Naina Singhi, Eileen Smith, Devang Thakkar, and Sandeep S. Dave
Biology and Molecular Pathogenesis of Mature T-Cell Lymphomas
José R. Cortés and Teresa Palomero
Biological and Translational Considerations regarding the Recent Therapeutic Successes and Upcoming Challenges for Multiple Myeloma
Constantine S. Mitsiades


review:  “Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. All chapters are well written and informative. This scientific volume will certainly be helpful to researchers and medical doctors and to medical students undertaking relevant preclinical training.”