Description
Stem cells are the progenitors of specialized cell types in the body and have the ability to self-renew. They play critical roles during embryonic development and in the maintenance and repair of adult tissues. Given their plasticity and regenerative abilities, stem cells provide opportunities for treating human diseases such as diabetes. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights. In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. This volume is therefore an indispensable reference for molecular, cell, and developmental biologists, as well as anyone wishing to explore the possibilities of stem cells in regenerative medicine and tissue engineering.
Contents
- Preface
- Modeling Brain Disorders Using Induced Pluripotent Stem Cells
- Krishna C. Vadodaria, Jeffrey R. Jones, Sara Linker, and Fred H. Gage
- Brain Organoids: Human Neurodevelopment in a Dish
- Silvia Benito-Kwiecinski and Madeline A. Lancaster
- Toward Combined Cell and Gene Therapy for Genodermatoses
- Laura De Rosa, Maria Carmela Latella, Alessia Secone Seconetti, Cecilia Cattelani, Johann W. Bauer, Sergio Bondanza, and Michele De Luca
- Development of Stem Cell Therapies for Retinal Degeneration
- Emma L. West, Joana Ribeiro, and Robin R. Ali
- Next-Generation Biomaterials for Culture and Manipulation of Stem Cells
- Koichiro Uto, Christopher K. Arakawa, and Cole A. DeForest
- A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia
- Daniel T. Montoro, Adam L. Haber, Jennifer E. Rood, Aviv Regev, and Jayaraj Rajagopal
- A Stem Cell Approach to Cure Type 1 Diabetes
- Aharon Helman and Douglas A. Melton
- Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas
- Silvia Ruzittu, David Willnow, and Francesca M. Spagnoli
- Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation
- Lara Al zouabi and Allison J. Bardin
- Niche Cells and Signals that Regulate Lung Alveolar Stem Cells In Vivo
- Nicholas H. Juul, Courtney A. Stockman, and Tushar J. Desai
- Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo Imaging
- Rudra Nayan Das and Karina Yaniv
- Specification of the First Mammalian Cell Lineages In Vivo and In Vitro
- Melanie D. White and Nicolas Plachta
- Advancing Stem Cell Research through Multimodal Single-Cell Analysis
- Iwo Kucinski and Berthold Gottgens
- Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy
- Arianna Fumagalli, Lotte Bruens, Colinda L.G.J. Scheele, and Jacco van Rheenen
- Mouse Spermatogenesis Reflects the Unity and Diversity of Tissue Stem Cell Niche Systems
- Shosei Yoshida
- Tracing the Dynamics of Stem Cell Fate
- Lemonia Chatzeli and Benjamin D. Simons
- Index
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