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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2020 • ISSN 0890-9369; Volume 34 includes full online access
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January - December 2020, 24 semimonthly issues
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Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetics Society.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2020 • ISSN: 1088-9051; Volume 30 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2020, 12 monthly issues
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In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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Genes & Development [Journal]
Learning & Memory [Journal]
RNA [Journal]
 
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Learning & Memory

Edited By John H. Byrne, University of Texas School of Medicine

Online Features: Internet edition – Learning & Memory Online at Stanford University Libraries' HighWire Press

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© 2020 • ISSN 1549-5485; Volume 27; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2020, 12 online  issues
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Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.

 
 

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Genes & Development [Journal]
Genome Research [Journal]
RNA [Journal]
 
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CSH Perspectives in Medicine

Online Features: CSH Perspectives in Medicine – CSH Perspectives in Medicine at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 2157-1422; Volume 10 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2020, 12 monthly issues
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Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.

Please visit www.perspectivesinmedicine.org for complete information about the journal.

Subject Coverage includes:

  • Addiction
  • Aging
  • Alzheimer Disease
  • Anemia
  • Antibiotic Resistance
  • Bacterial Pathogens
  • Bone Disease
  • Cancer
  • Cystic Fibrosis
  • Diabetes
  • Heart Disease
  • Hemoglobin
  • HIV
  • Influenza
  • Malaria
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson's Disease
  • Prion Diseases
  • Skin Diseases
  • Schizophrenia
 
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CSH Perspectives in Biology

Online Features: CSH Perspectives in Biology – CSH Perspectives in Biology at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 1943-0264; Volume 12 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact
cironek@cshl.edu.

January - December 2020, 12 monthly issues
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A new online publication for the molecular life sciences

Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground

In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.

For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the bible of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.

Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.

According to the journal's Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. "There are many review articles published each year, but they're usually on one particular aspect of one particular field," he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer's to plant biology."

CSH Perspectives articles are all commissioned as �collections� by a board of eminent academic editors and gradually accumulate online at the journal's website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.

The new publication is produced online in partnership with Stanford University Library's HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.

 
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CSH Protocols

Edited By Richard Sever, Cold Spring Harbor Laboratory Press

Online Features: Internet edition – Cold Spring Harbor Protocols at Stanford University Libraries' HighWire Press

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© 2020 • ISSN: 1559-6095; Volume 15; includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2020, 12 monthly issues
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  • The online source of trusted techniques in molecular and cellular biology
  • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
  • Frequently updated and annotated
  • Interactive, customizable, and fully searchable

The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor's renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.

Features include:
  • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting
  • Customizable, topic-based e-mail alerts for the latest updates in a particular field
  • Personal folders for storing favorite protocols and searches
  • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
  • A kit search tool for fast access to time-saving resources
  • An online manuscript submission system for authors to contribute new protocols

CSH Protocols — More Than Just Methods.

Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.

  • Available exclusively via institutional site license
  • ISSN 1559-6095 / online, monthly

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RNA

Edited By Timothy W. Nilsen, Editor-in-Chief, Case Western Reserve University; Thomas R. Cech, Howard Hughes Medical Institute; David Engelke, University of Michigan; Eric Westhof, CNRS Strasbourg; Marvin Wickens, University of Wisconsin

Online Features: Internet edition – RNA Online at Stanford University Libraries' HighWire Press

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© 2020 • ISSN 1355-8382; Volume 26; includes full online access.
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
(Published by CSHL Press for The RNA Society)
January - December 2020, 12 monthly issues
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RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.

 
 

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Genes & Development [Journal]
Genome Research [Journal]
Learning & Memory [Journal]
 
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RNA Control and Regulation

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

More INFO Below
Description
Contents
   

© 2020 • 310 pages, illustrated (91 color and 61 B&W), index
Hardcover • $81.00 • ISBN 978-1-621823-95-7


 

Description

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

 
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Contents

Symposium Participants
Foreword
Global Analyses and Structures
Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation
Jeetayu Biswas, Leti Nunez, Sulagna Das, Young J. Yoon, Carolina Eliscovich, and Robert H. Singer
Pre-mRNA Splicing in the Nuclear Landscape
Tucker J. Carrocci and Karla M. Neugebauer
Recognition of Poly(A) RNA through Its Intrinsic Helical Structure
Terence T.L. Tang and Lori A. Passmore
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation
Furqan M. Fazal and Howard Y. Chang
Gene Regulation
Transcriptional Coactivator PGC-1a Binding to Newly Synthesized RNAvia CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation
Xavier Rambout, Hana Cho, and Lynne E. Maquat
Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels
Jia-Yu Chen, Do-Hwan Lim, and Xiang-Dong Fu
Linking RNA Processing and Function
Run-Wen Yao, Chu-Xiao Liu, and Ling-Ling Chen
Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination
Deirdre C. Tatomer and Jeremy E. Wilusz
Regulation of RNA Functions
3′ UTRs Regulate Protein Functions by Providing a Nurturing Niche during Protein Synthesis
Christine Mayr
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
Rosa Luna, Ana G. Rondón, Carmen Pérez-Calero, Irene Salas-Armenteros, and Andrés Aguilera
U1 snRNP Telescripting Roles in Transcription and Its Mechanism
Chao Di, Byung Ran So, Zhiqiang Cai, Chie Arai, Jingqi Duan, and Gideon Dreyfuss
Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection
Matthew G. Thompson and Kristen W. Lynch
Chromatin and RNA
Small RNA Function in Plants: From Chromatin to the Next Generation
Jean-Sébastian Parent, Filipe Borges, Atsushi Shimada, and Robert A. Martienssen
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans
Anna Mattout, Dimos Gaidatzis, Véronique Kalck, and Susan M. Gasser
To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome
Mahesh Lingaraju, Jan M. Schuller, Sebastian Falk, Piotr Gerlach, Fabien Bonneau, Jérôme Basquin, Christian Benda, and Elena Conti
Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
Hadas Hezroni, Rotem Ben Tov Perry, and Igor Ulitsky
Small RNAs and Defense Systems
How Complementary Targets Expose the microRNA 3′ End for Tailing and Trimming during Target-Directed microRNA Degradation
Paulina Pawlica, Jessica Sheu-Gruttadauria, Ian J. MacRae, and Joan A. Steitz
Dicer’s Helicase Domain: A Meeting Place for Regulatory Proteins
Sarah R. Hansen, Adedeji M. Aderounmu, Helen M. Donelick, and Brenda L. Bass
Reconstitution of siRNA Biogenesis In Vitro: Novel Reaction Mechanisms and RNA Channeling in the RNA-Directed DNA Methylation Pathway
Jasleen Singh and Craig S. Pikaard
Membraneless Bodies and Phase Separation
RNP Granule Formation: Lessons from P-Bodies and Stress Granules
Giulia Ada Corbet and Roy Parker
Biophysical Properties of HP1-Mediated Heterochromatin
Serena Sanulli, John D. Gross, and Geeta J. Narlikar
Architectural RNAs for Membraneless Nuclear Body Formation
Tomohiro Yamazaki, Shinichi Nakagawa, and Tetsuro Hirose
Summary
Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies
Byung Ran So and Gideon Dreyfuss
Dorcas Cummings Lecture
Dorcas Cummings Lecture
Jennifer Doudna
Conversations at the Symposium
Karen Adelman
Andrés Aguilera
David Bartel
Ling-Ling Chen
Caroline Dean
Susan Gasser
Samie Jaffrey
Leemor Joshua-Tor
Alberto Kornblihtt
Adrian Krainer
Lynne Maquat
Karla Neugebauer
Nicholas Proudfoot
Oliver Rando
Phillip Sharp
Maria-Elena Torres-Padilla
Igor Ulitsky
Jeremy Wilusz
Feng Zhang
Author Index
Subject Index
 

$72.90
This bundle includes the following products:

RNA Control and Regulation
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Click to Enlarge

RNA Control and Regulation

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

More INFO Below
Description
Contents
   

© 2020 • 310 pages, illustrated (91 color and 61 B&W), index
Paperback • $81.00 • ISBN 978-1-621823-92-6


 

Description

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

 
Add To Cart  Add this Title to Order List 
 

Contents

Symposium Participants
Foreword
Global Analyses and Structures
Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation
Jeetayu Biswas, Leti Nunez, Sulagna Das, Young J. Yoon, Carolina Eliscovich, and Robert H. Singer
Pre-mRNA Splicing in the Nuclear Landscape
Tucker J. Carrocci and Karla M. Neugebauer
Recognition of Poly(A) RNA through Its Intrinsic Helical Structure
Terence T.L. Tang and Lori A. Passmore
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation
Furqan M. Fazal and Howard Y. Chang
Gene Regulation
Transcriptional Coactivator PGC-1a Binding to Newly Synthesized RNAvia CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation
Xavier Rambout, Hana Cho, and Lynne E. Maquat
Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels
Jia-Yu Chen, Do-Hwan Lim, and Xiang-Dong Fu
Linking RNA Processing and Function
Run-Wen Yao, Chu-Xiao Liu, and Ling-Ling Chen
Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination
Deirdre C. Tatomer and Jeremy E. Wilusz
Regulation of RNA Functions
3′ UTRs Regulate Protein Functions by Providing a Nurturing Niche during Protein Synthesis
Christine Mayr
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
Rosa Luna, Ana G. Rondón, Carmen Pérez-Calero, Irene Salas-Armenteros, and Andrés Aguilera
U1 snRNP Telescripting Roles in Transcription and Its Mechanism
Chao Di, Byung Ran So, Zhiqiang Cai, Chie Arai, Jingqi Duan, and Gideon Dreyfuss
Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection
Matthew G. Thompson and Kristen W. Lynch
Chromatin and RNA
Small RNA Function in Plants: From Chromatin to the Next Generation
Jean-Sébastian Parent, Filipe Borges, Atsushi Shimada, and Robert A. Martienssen
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans
Anna Mattout, Dimos Gaidatzis, Véronique Kalck, and Susan M. Gasser
To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome
Mahesh Lingaraju, Jan M. Schuller, Sebastian Falk, Piotr Gerlach, Fabien Bonneau, Jérôme Basquin, Christian Benda, and Elena Conti
Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
Hadas Hezroni, Rotem Ben Tov Perry, and Igor Ulitsky
Small RNAs and Defense Systems
How Complementary Targets Expose the microRNA 3′ End for Tailing and Trimming during Target-Directed microRNA Degradation
Paulina Pawlica, Jessica Sheu-Gruttadauria, Ian J. MacRae, and Joan A. Steitz
Dicer’s Helicase Domain: A Meeting Place for Regulatory Proteins
Sarah R. Hansen, Adedeji M. Aderounmu, Helen M. Donelick, and Brenda L. Bass
Reconstitution of siRNA Biogenesis In Vitro: Novel Reaction Mechanisms and RNA Channeling in the RNA-Directed DNA Methylation Pathway
Jasleen Singh and Craig S. Pikaard
Membraneless Bodies and Phase Separation
RNP Granule Formation: Lessons from P-Bodies and Stress Granules
Giulia Ada Corbet and Roy Parker
Biophysical Properties of HP1-Mediated Heterochromatin
Serena Sanulli, John D. Gross, and Geeta J. Narlikar
Architectural RNAs for Membraneless Nuclear Body Formation
Tomohiro Yamazaki, Shinichi Nakagawa, and Tetsuro Hirose
Summary
Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies
Byung Ran So and Gideon Dreyfuss
Dorcas Cummings Lecture
Dorcas Cummings Lecture
Jennifer Doudna
Conversations at the Symposium
Karen Adelman
Andrés Aguilera
David Bartel
Ling-Ling Chen
Caroline Dean
Susan Gasser
Samie Jaffrey
Leemor Joshua-Tor
Alberto Kornblihtt
Adrian Krainer
Lynne Maquat
Karla Neugebauer
Nicholas Proudfoot
Oliver Rando
Phillip Sharp
Maria-Elena Torres-Padilla
Igor Ulitsky
Jeremy Wilusz
Feng Zhang
Author Index
Subject Index
 

$72.90
This bundle includes the following products:

RNA Control and Regulation
   

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RNA Control and Regulation

(Cold Spring Harbor Symposia on Quantitative Biology LXXXIV)

Subject Area(s):  BiotechnologyMolecular BiologyGeneticsBiochemistry

Edited by Terri Grodzicker, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

Download a Free Excerpt from RNA Control and Regulation:

Foreword
Conversations at the Symposium: David Bartel, Adrian Krainer, and Feng Zhang
Indexes


Due August 2020 • 310 pages, illustrated (91 color and 61 B&W), index
Paperback • $89 71.20
ISBN  978-1-621823-92-6
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  •     Description    
  •     Contents    

Description

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

Contents

Symposium Participants
Foreword
Global Analyses and Structures
Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence-Specific RNA Regulation
Jeetayu Biswas, Leti Nunez, Sulagna Das, Young J. Yoon, Carolina Eliscovich, and Robert H. Singer
Pre-mRNA Splicing in the Nuclear Landscape
Tucker J. Carrocci and Karla M. Neugebauer
Recognition of Poly(A) RNA through Its Intrinsic Helical Structure
Terence T.L. Tang and Lori A. Passmore
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation
Furqan M. Fazal and Howard Y. Chang
Gene Regulation
Transcriptional Coactivator PGC-1a Binding to Newly Synthesized RNAvia CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation
Xavier Rambout, Hana Cho, and Lynne E. Maquat
Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels
Jia-Yu Chen, Do-Hwan Lim, and Xiang-Dong Fu
Linking RNA Processing and Function
Run-Wen Yao, Chu-Xiao Liu, and Ling-Ling Chen
Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination
Deirdre C. Tatomer and Jeremy E. Wilusz
Regulation of RNA Functions
3′ UTRs Regulate Protein Functions by Providing a Nurturing Niche during Protein Synthesis
Christine Mayr
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
Rosa Luna, Ana G. Rondón, Carmen Pérez-Calero, Irene Salas-Armenteros, and Andrés Aguilera
U1 snRNP Telescripting Roles in Transcription and Its Mechanism
Chao Di, Byung Ran So, Zhiqiang Cai, Chie Arai, Jingqi Duan, and Gideon Dreyfuss
Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection
Matthew G. Thompson and Kristen W. Lynch
Chromatin and RNA
Small RNA Function in Plants: From Chromatin to the Next Generation
Jean-Sébastian Parent, Filipe Borges, Atsushi Shimada, and Robert A. Martienssen
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans
Anna Mattout, Dimos Gaidatzis, Véronique Kalck, and Susan M. Gasser
To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome
Mahesh Lingaraju, Jan M. Schuller, Sebastian Falk, Piotr Gerlach, Fabien Bonneau, Jérôme Basquin, Christian Benda, and Elena Conti
Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
Hadas Hezroni, Rotem Ben Tov Perry, and Igor Ulitsky
Small RNAs and Defense Systems
How Complementary Targets Expose the microRNA 3′ End for Tailing and Trimming during Target-Directed microRNA Degradation
Paulina Pawlica, Jessica Sheu-Gruttadauria, Ian J. MacRae, and Joan A. Steitz
Dicer’s Helicase Domain: A Meeting Place for Regulatory Proteins
Sarah R. Hansen, Adedeji M. Aderounmu, Helen M. Donelick, and Brenda L. Bass
Reconstitution of siRNA Biogenesis In Vitro: Novel Reaction Mechanisms and RNA Channeling in the RNA-Directed DNA Methylation Pathway
Jasleen Singh and Craig S. Pikaard
Membraneless Bodies and Phase Separation
RNP Granule Formation: Lessons from P-Bodies and Stress Granules
Giulia Ada Corbet and Roy Parker
Biophysical Properties of HP1-Mediated Heterochromatin
Serena Sanulli, John D. Gross, and Geeta J. Narlikar
Architectural RNAs for Membraneless Nuclear Body Formation
Tomohiro Yamazaki, Shinichi Nakagawa, and Tetsuro Hirose
Summary
Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies
Byung Ran So and Gideon Dreyfuss
Dorcas Cummings Lecture
Dorcas Cummings Lecture
Jennifer Doudna
Conversations at the Symposium
Karen Adelman
Andrés Aguilera
David Bartel
Ling-Ling Chen
Caroline Dean
Susan Gasser
Samie Jaffrey
Leemor Joshua-Tor
Alberto Kornblihtt
Adrian Krainer
Lynne Maquat
Karla Neugebauer
Nicholas Proudfoot
Oliver Rando
Phillip Sharp
Maria-Elena Torres-Padilla
Igor Ulitsky
Jeremy Wilusz
Feng Zhang
Author Index
Subject Index
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