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The Skin and Its Diseases

Subject Area(s):  Cell BiologyHuman Biology and Disease

Edited by Anthony Oro, Professor, Dermatology, Stanford University School of Medicine, Department of Dermatology / Oro Lab; Fiona Watt, Director, Centre for Stem Cells and Regenerative Medicine, King's College London

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© 2014 • 490 pp., illus. (82 color, 6 B&W), index
Hardcover •
ISBN  978-1-621820-23-9

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  •     Description    
  •     Contents    


The skin is the largest organ in the human body, and it is constantly bombarded with external stimuli. It offers protection and insulation, prevents dehydration, and senses the environment. But irritants, infections, and inherited genetic mutations cause hundreds of skin disorders, ranging from mild cosmetic conditions to serious diseases such as cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology of the skin, its numerous functions, and the diseases that affect it. Contributors discuss the various components of the epidermis, dermis, hair follicles, glands, and nerve endings that make up the skin, the molecular pathways and processes that underlie their development and function, and what happens when these processes go awry. The important functions of skin stem cell populations in tissue development, homeostasis, and repair are described, as are the roles of resident and recruited cells in inflammatory responses. Several chapters are devoted to cutaneous disorders, including alopecias, carcinomas, melanomas, psoriasis, and genetic diseases such as epidermolysis bullosa.

Topics such as age-related changes to the skin, the roles of resident microbes in skin health and disease, and advances in therapies for cutaneous disorders are also covered. This volume is therefore a vital reference for dermatologists, cancer biologists, cell and developmental biologists, immunologists, and all who seek to understand the numerous functions and diseases of this major organ.


Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin
Kai Kretzschmar and Fiona M. Watt
Lineage Analysis of Epidermal Stem Cells
Maria P. Alcolea and Philip H. Jones
The Genetics of Human Skin Disease
Gina M. DeStefano and Angela M. Christiano
Epidermal Polarity Genes in Health and Disease
Frederik Tellkamp, Susanne Vorhagen, and Carien M. Niessen
The Skin and Its Diseases: Epidermal Barriers
Ken Natsuga
Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease
Jodi L. Johnson, Nicole A. Najor, and Kathleen J. Green
Sweat Gland Progenitors in Development, Homeostasis, and Wound Repair
Catherine Lu and Elaine Fuchs
Diversification and Specialization of Touch Receptors in Skin
David M. Owens and Ellen A. Lumpkin
Adipocytes in Skin Health and Disease
Guillermo Rivera, Brett Shook, and Valerie Horsley
Melanocytes and Their Diseases
Yuji Yamaguchi and Vincent J. Hearing
Wound Healing and Skin Regeneration
Makoto Takeo, Wendy Lee, and Mayumi Ito
Immunology and Skin in Health and Disease
Jillian M. Richmond and John E. Harris
The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle
Bruce A. Morgan
Macro-Environmental Regulation of Hair Cycling and Collective Regenerative Behavior
Maksim V. Plikus and Cheng-Ming Chuong
Microbial Ecology of the Skin in the Era of Metagenomics and Molecular Microbiology
Geoffrey D. Hannigan and Elizabeth A. Grice
Natural and Sun-Induced Aging of Human Skin
Laure Rittié and Gary J. Fisher
Long Non-Coding RNA: Significance and Potential in Skin Biology
Derrick C. Wan and Kevin C. Wang
Epigenetic Regulation of Epidermal Differentiation
Carolina N. Perdigoto, Victor J. Valdes, Evan S. Bardot, and Elena Ezhkova
p53/p63/p73 in the Epidermis in Health and Disease
Vladimir A. Botchkarev and Elsa R. Flores
Cutaneous Notch Signaling in Health and Disease
Craig Nowell and Freddy Radtke
Paola Di Meglio, Federica Villanova, and Frank O. Nestle
An Overview of Alopecias
Ji Qi and Luis A. Garza
Advanced Treatment for Basal Cell Carcinomas
Scott X. Atwood, Ramon J. Whitson, and Anthony E. Oro
Modeling Cutaneous Squamous Carcinoma Development in the Mouse
Phillips Y. Huang and Allan Balmain
Melanoma: Clinical Features and Genomic Insights
Elena B. Hawryluk and Hensin Tsao
Gene Therapy for Skin Diseases
Emily Gorell, Ngon Nguyen, Alfred Lane, and Zurab Siprashvili
Cell Therapy in Dermatology
Gabriela Petrof, Alya Abdul-Wahab, and John A. McGrath
Induced Pluripotent Stem Cells in Dermatology: Potentials, Advances, and Limitations
Ganna Bilousova and Dennis R. Roop