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The p53 Family

Subject Area(s):  Developmental BiologyCell BiologyMolecular BiologyCancer Biology

Edited by Arnold J. Levine, Institute for Advanced Study, Princeton; David P. Lane, A *Star (Agency for Science, Technology and Research), Singapore

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© 2010 • 360 pp., illus. (48 color, 19 b/w), index
Trim size: 7" x 10"
Hardcover •
ISBN  978-0-879698-30-0

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The p53 Family front cover image courtesy of Andreas Joerger (see article by Andreas C. Joerger, and Alan R. Fersht).

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The p53 tumor suppressor gene—the "guardian of the genome"—protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line.

This collection also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.


The Origins and Evolution of the p53 Family of Genes
Vladimir A. Belyi, Prashanth Ak, Elke Markert, Haijian Wang, Wenwei Hu, Anna Puzio-Kuter, and Arnold J. Levine
The Tumor Suppressor p53: From Structures to Drug Discovery
Andreas C. Joerger and Alan R. Fersht
The Isoforms of the p53 Protein
Marie P. Khoury and Jean-Christophe Bourdon
p63 and p73, the Ancestors of p53
Volker Dötsch, Francesca Bernassola, Daniel Coutandin, Eleonora Candi, and Gerry Melino
Transcriptional Regulation by p53
Rachel Beckerman and Carol Prives
Posttranslational Modification of p53: Cooperative Integrators of Function
David W. Meek and Carl W. Anderson
The Regulation of the p53-mediated Stress Response by MDM2 and MDM4
Mary Ellen Perry
Tied Up in Loops: Positive and Negative Autoregulation of p53
Xin Lu
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Magali Olivier, Monica Hollstein, and Pierre Hainaut
Clinical Outcomes and Correlates of TP53 Mutations and Cancer
Ana I. Robles and Curtis C. Harris
Single-nucleotide Polymorphisms in the p53 Signaling Pathway
Lukasz F. Grochola, Jorge Zeron-Medina, Sophie Mériaux, and Gareth L. Bond
Tumor Suppressive Functions of p53
Jack T. Zilfou and Scott W. Lowe
p53 Regulation of Metabolic Pathways
Eyal Gottlieb and Karen H. Vousden
p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment
Zhaohui Feng
The Role of p53 Gene Family in Reproduction
Wenwei Hu
Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity
Lawrence A. Donehower
Mutant p53 Gain-of-Function in Cancer
Moshe Oren and Varda Rotter
Mouse Models of p53 Functions
Guillermina Lozano
Zebrafish Models of p53 Functions
Narie Y. Storer and Leonard I. Zon
Phylogeny and Function of the Invertebrate p53 Superfamily
Rachael Rutkowski, Kay Hofmann, and Anton Gartner
p53-based Cancer Therapy
David P. Lane, Chit Fang Cheok, and Sonia Lain
Pathologies Associated with the p53 Response
Andrei V. Gudkov and Elena A. Komarova
P53 Research: The Past Thirty Years and the Next Thirty Years
David Lane and Arnold Levine

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