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Parkinson's Disease

Subject Area(s):  Human Biology and DiseaseNeurobiology

Edited by Serge Przedborski, Columbia University

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© 2012 • 406 pp., illus. (36 4C images and 19 B&W), index
Hardcover •
ISBN  978-1-936113-32-3

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  •     Description    
  •     Contents    


First described as "the shaking palsy" in 1817 by James Parkinson, Parkinson's disease is a disabling neurodegenerative disorder that is common among the elderly. It involves the gradual depletion of brain cells that control balance and movement, causing trembling, muscle rigidity, and difficulty walking. Characteristic brain changes – such as the formation of Lewy bodies and the degeneration of dopamine-producing neurons – have been identified, but diagnostic tests and therapeutic options remain limited.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Parkinson's disease, from its neuropathological and clinical bases to the diagnostic challenges and therapeutic interventions. Contributors discuss the mutations in genes encoding proteins such as α-synuclein, parkin, and LRRK2 that cause Parkinson's disease; the roles of mitochondria, autophagy, protein quality control, and programmed cell death in disease progression; and the chemistry and anatomy of the basal ganglia that are affected. The use of functional neuroimaging and experimental models to probe the neurobiology of Parkinson's disease are also described.

Blending both the clinical and basic science of Parkinson's disease, this volume is a vital reference for neurobiologists, cell biologists, and pathologists pursuing the biological basis of Parkinson's disease, as well as scientists and clinicians interested in its diagnosis and treatment.


The History of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies
Christopher G. Goetz
Clinical Approach to Parkinson’s Disease: Features, Diagnosis, and Principles of Management
João Massano and Kailash P. Bhatia
Parkinson’s Disease and Parkinsonism: Neuropathology
Dennis W. Dickson
Genetics of Parkinson’s Disease
Christine Klein and Ana Westenberger
α-Synuclein in Parkinson’s Disease
Leonidas Stefanis
Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions
Lauren R. Kett and William T. Dauer
Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways
Mark R. Cookson
Genomics and Bioinformatics of Parkinson’s Disease
Sonja W. Scholz, Tim Mhyre, Habtom Ressom, Salim Shah, and Howard J. Federoff
Parkinson’s Disease: Gene Therapies
Philippe G. Coune, Bernard L. Schneider, and Patrick Aebischer
Functional Neuroanatomy of the Basal Ganglia
José L. Lanciego, Natasha Luquin, and José A. Obeso
Functional Neuroimaging in Parkinson’s Disease
Martin Niethammer, Andrew Feigin, and David Eidelberg
Motor Control Abnormalities in Parkinson’s Disease
Pietro Mazzoni, Britne Shabbott, and Juan Camilo Cortés
Physiological Phenotype and Vulnerability in Parkinson’s Disease
D. James Surmeier, Jaime N. Guzman, Javier Sanchez, and Paul T. Schumacker
Modeling Parkinson’s Disease in Primates: The MPTP Model
Gregory Porras, Qin Li, and Erwan Bezard
A Guide to Neurotoxic Animal Models of Parkinson’s Disease
Kim Tieu
Animal Models of Parkinson’s Disease: Vertebrate Genetics
Yunjong Lee, Valina L. Dawson, and Ted M. Dawson
Drosophila as a Model to Study Mitochondrial Dysfunction in Parkinson’s Disease
Ming Guo
Mitochondrial Biology and Parkinson’s Disease
Celine Perier and Miquel Vila
The Role of Autophagy in Parkinson’s Disease
Melinda A. Lynch-Day, Kai Mao, Ke Wang, Mantong Zhao, and Daniel J. Klionsky
Disruption of Protein Quality Control in Parkinson’s Disease
Casey Cook, Caroline Stetler, and Leonard Petrucelli
Programmed Cell Death in Parkinson’s Disease
Katerina Venderova and David S. Park
Innate Inflammation in Parkinson’s Disease
V. Hugh Perry
Inflammation and Adaptive Immunity in Parkinson’s Disease
R. Lee Mosely, Jessica A. Hutter-Saunders, David K. Stone, and Howard E. Gendelman