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Telomeres, Second Edition

(Cold Spring Harbor Monograph Series 45)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Cell BiologyMolecular BiologyCancer Biology

Edited by Titia de Lange, The Rockefeller University; Vicki Lundblad, The Salk Institute for Biological Sciences; Elizabeth Blackburn, University of California, San Francisco

© 2006 • 576 pp., illus., index
Hardcover •
ISBN  978-087969734-1

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An up–to–date survey of the current exciting state of telomere biology. Telomeres—specialized structures found at the ends of chromosomes— are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.


1. A History of Telomere Biology
2. The Telomerase Ribonucleoprotein Particle
3. Telomerase Biochemistry and Biogenesis
4. Telomerase and Human Cancer
5. Modeling Cancer and Aging in the Telomerase–deficient Mouse
6. Telomerase Deficiency and Human Disease
7. Telomerase–independent Maintenance of Mammalian Telomeres
8. Telomerase–independent Telomere Maintenance in Yeast
9. Meiotic Telomeres
10. Telomere Position Effect: Silencing Near the End
11. The Structural Biology of Telomeres
12. Budding Yeast Telomeres
13. Mammalian Telomeres
14. Drosophila Telomeres
15. Ciliate Telomeres
16. Fission Yeast Telomeres
17. Plant Telomeres
Appendix: A Personal Account of The Discovery of Telomerase


review:  “...a ‘must have’ for all telomere aficionados. The book will also be very valuable to undergraduates seeking advanced knowledge and to graduate students and other newcomers to the telomere field...”
      —Genetical Research

review:  “The second edition of Telomeres is an outstanding summary of what has become an area of biology with substantial range and depth. It has proven a treasure trove for researchers ranging from enzymologists and structural biologists to developmental and cancer biologists to gerontologists. This book is a compact guide to the exciting findings pertinent to these diverse fields. Written and edited by major leaders of this field, this volume is well referenced and will be of great use to educators of college, graduate, and medical students.”
      —The Quarterly Review of Biology